According to ZHANG Zhong-jing, the main reason for the stroke was the exogenous wind, and the most important pathogenesis was the deficiency of qi and exogenous pathogenic factor. Three methods are stressed to cure the stroke: the equal treatment focused on the liver and the spleen, the use of tranquilizing medicine to stop the wind, and the use of strengthening body resistance to get rid of the exogenous pathogenic factors. While YE Tian-shi considered that the main reason for stroke was the deficiency of liver-yin and kidney-yin. The chief pathogenesis in stroke was the yang transforms to the interior wind. There are three therapeutic features in the treatment: the equal treatment focused on the liver and the spleen, the synchronous treatment of the liver and stomach, and select the medicine according to the four seasons climate. ZHANG Zhong-jing's theory of exogenous wind and YE Tian-shi's theory of yang transforms to the interior wind not only reflect the different angles in treatment for stroke, but also reflect the development of pathogenesis of stroke in the history.