BACKGROUND: Drug-controlled release preparation by drugs or other active substances combined with carriers, has been an important development trend in field of pharmacy. However different characteristics of controlled release drug carrier materials leas to different drug release behaviors, so recent researches focus on a new type of drug carrier material to obtain the satisfactory drug release. OBJECTIVE: To introduce some drug carrier materials, and analyze those materials' characteristics and their application on drug controlled-release. RETRIEVAL STRATEGY: A computer-based search was undertaken on China Journal Full-text Database from January 1998 to June 2007, with the Keywords of "polymeric hydrogel, polylactic acid, chitosan, silk fibroin, drug controlled-release, drug carrier" and language was limited to Chinese. Inclusion criteria: ①preparations and characteristics of various drug carrier materials;②drug controlled release of various drug carrier materials. Exclusion criteria: outdated literatures. LITERATURE EVALUATION: Eighty-six related articles were screened out, and 28 of them met the criteria, including 10 were reviews and others were clinical or basic experiments. DATA SYNTHESIS: ① At present, the materials applied for drug carrier include polymeric hydrogel, polylactic acid/poly(lactic-co-glycolic acid), chitosan and their derivates, silk fibroin and so on.②Intellectual polymeric hydrogel can respond swelling and contraction for the stimulation of temperature, acidity, pressure and light, etc. And the specific environment sensitiveness enlarges its application in drug delivery system.③Polylactic acid and poly(lactic-co-glycolic acid), as a kind of biodegradable polymer materials, represent biocompatibility, biodegradability and non-toxic degradation products. As for controlled release drug carrier material, it can influence drug release by modulating degradation of polylactic acid, so as to increase drug efficacy.④Chitosan is satisfactory in adsorbability, film forming ability and permeability. Water-soluble chitosan with low relative molecular mass is prone to degrade and difficult to accumulate, so chitosan nanoparticles or chitosan microspheres as carriers for drug delivery system have been the hot topic of recent researches.⑤Native polymer material silk fibroin is non-toxic and non-stimulative, shows good physical, chemical and biological characteristics, as well as satisfactory histocompatibility. The pH value responsibility and zymohydrolysis are also observed when loading and releasing drugs. Chemical modification and addition of other compounds will increase the characteristics and the drug-controlled release of silk fibroin. CONCLUSION: Various drug carrier materials show good biocompatibility, biodegradability, physicochemical and biological stability, extremely low toxicity, and high drug loading property. But the material's performance should be synthesized and modified in practical application to satisfy various preparations of drug-controlled release by specific performance and structure.

Polypeptide and protein microspheres can elevate drug availability, but drug devitalization and drug fast release can result in side effects during microsphere preparation. Fast release in the body is a burning question facting investigators who studying microsphere controlled release system. Relative molecular mass, concentration, structure and drug content of the polyme can greatly affect drug fast release. Fast release can be controlled by structural modification, using additives, controlling particl diameter of microspheres and decreasing drug content.

Calcium phosphate ceramics, such as tricalcium phosphate (TCP) and hydroxyapatite (HA) are commonly used as bone substitutes. These materials have different physical and chemical properties and, therefore, display different interactions with the host tissue. Factors such as porosity,osteoconductivity,and biocompatibility seem to become increasingly important in the development of new artificial bone replacement materials. This article focuses on the relationship between the physical and chemical properties of calcium phosphate ceramics and the host tissue.

Objective: To study the impact of basic medical insurance on household consumption. Methods: According to the panel data of the east, central and west regions from 2002 to 2011, time and entity fixed effect model (Two-way FE) is established to test the relationship between the basic medical insurance and household consumption. Results: The basic medical insurance has significant positive effects on consumption, the consumption increased 10%, 16% and 19% in regions of East, Middle and West, respectively. Conclusion: The construction and improvement of the social medical insurance system improve the growth of the consumption, and the government should enhance the security, and consider the regional differences at the same time.

Abstract: Objective　To investigate the frequency of peripheral blood T cells among patients positive for both hepatitis B virus surface antigen (HBsAg) and surface antibody (HBsAb). Methods　 Thirty six patients with co-existence of HBsAg and HBsAb diagnosed were enrolled as the experimental group, who were admitted by Shanghai tenth people's hospital and Wuxi 9th people's hospital from 2014 to 2020. while 40 patients tested positive for HBsAg and negative for HBsAb served as controls, who were admitted by Wuxi 9th people's hospital. Flow cytometry was used to detect and compare the proportions of peripheral blood CD3+, CD4+ and CD8+ T cells between the experimental and control groups. In addition, the associations of serum HBsAb level with peripheral blood T cell proportions, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were examined among chronic hepatitis B patients with co-existence of HBsAg and HBsAb using Pearson correlation analysis. Results　The median age, gender distribution, mean ALT and AST concentrations, proportion of HBV DNA viral load>103 copies/mL, seroprevalence of HBV E antigen (HBeAg), seroprevalence of HBV E antibody (HBeAb), seroprevalence of HBV core antibody (HBcAb) were comparable between the experimental and control groups, and there were no significant difference in them (P>0.05). There were no significant difference between the experimental and control groups in terms of CD3+ T cell proportion [(71.83±1.50)% vs (72.75±1.47)%; t=0.66, P>0.05], CD4+ T cell proportion [(36.81±1.53)% vs (39.88±1.57)%; t=1.43, P>0.05] and CD8+ T cell proportion [(33.17±2.04)% vs (32.40±1.75)%; t=0.77, P>0.05]. Pearson correlation analysis revealed that the serum HBsAb level did not significantly correlate with peripheral blood CD3+ (r=0.026, P=0.65), CD4+ (r=‒0.08, P=0.16) and CD8+ T cell proportions (r=0.09, P=0.24), CD4+/CD8+ T proportion (r=‒0.005, P=0.35), serum ALT (r=0.04, P=0.56) and AST levels (r=0.002, P=0.69) among chronic hepatitis B patients with co-existence of HBsAg and HBsAb. Conclusions　There are no significant differences between HBsAg+/HBsAb+ and HBsAg+/HBsAb- CHB patients in terms of peripheral blood CD3+, CD4+ and CD8+ T cell proportions.

Objective To investigate the effect of pretreatment with penehychidine hydrochloride(PHCD) on NF-κB activity in the lung tissue following acute lung injury(ALI)induced by hemorrhagic shock in rats.Methods Twenty-four Wistar rats of both sexes weighing 200-250 g were randomly divided into 3 groups (n=8 each):group Ⅰ sham operation (group S);group Ⅱ ALI and group Ⅲ PHCD.The animals were anesthetized with intraperitoneal chloral hydrate 350 mg/kg.Hemorrhagic shock was produced in group Ⅱ and Ⅲ.Right carotid artery was cannulated for BP monitoring.Left femoral artery was cannulated for blood letting.MAP was reduced to 35-45 mm Hg within 10 min and maintained for 1 h in group ALI and PHCD(group Ⅱ andⅢ).The animals were then resuscitated with blood and normal saline.PHCD 2 mg/kg was given iv immediately before blood-letting in group PHCD.Blood samples were obtained from artery at 6 h after hemorrhagic shock wag induced for blood gas analysis and from right auricle for determination of plasma TNF-α concentration by ELISA.The lungs were then harvested for microscopic examination and determination of the expression of NF-κB p65 by immuno-histochemistry and W/D lung weight ratio.Results The plasma TNF-α concentration and expression of NF-κB p65 in the lung tissue were significantly increased in group ALI and PHCD as compared with group S and were significantly lower in group PHCD than in group ALI.There was less damage to the lung tissue in group PHCD than in group ALI.Conclusion PHCD pretreatment can attenuate ALl induced by hemorrhagic shock by inhibiting NF-κB activity.

Objective To observe the changes of plasma lipoprotein concentrations after an oral glucose tolerance test and research their relation to insulin resistance in Type 2 diabetic patients.Methods The age,duration of diabetes,sex,waist circumference,hip circumference,waist-hip ratio,height,body weight,body mass index ( BMI ),systolic blood pressure,diastolic blood pressure,fasting plasma glucose,HbAl C,fasting insulin,and fasting and 60-,120-,180-minute post-load plasma glucose,plasma insulin,triglycerides ( TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol(LDL-C) and total cholesterol(TC) after a 75-g oral glucose tolerance test were measured in 26 Type 2 diabetic patients.Comparison of plasma fasting lipoprotein concentrations and postload lipoprotein concentrations was made,and the relation between fasting and post-load lipoprotein concentrations and Homa-IR was researched.Stepwise multiple regression analysis was applied to investigate the areas under the lipoproteins' curves over 180 minutes.Results The declination of post-load lipoprotein concentrations after the 75-g glucose tolerance test was statistically significant( all P ＜0.01 ).Plasma TG concentration both in fasting and post-load state was positively related to Homa-IR( all P ＜ 0.05 ),and plasma HDL-C concentration in fasting and post-load state was negatively related to Homa-IR( all P ＜ 0.05 ).However,the correlation between both fasting and post-load state LDL-C and TC concentration and Homa-IR had no statistical significance.Moreover,stepwise multiple regression analysis revealed Homa-IR was the independent factor capable of modulating the area of HDL-C curve over 180 minutes after the 75-g glucose tolernce test ( P ＜ 0.05 ).Conclusion There was a significant declination of plasma lipoproteins after a 75-g glucose tolerance test,and plasma fasting and post-load TG and HDL-C concentrations were related to insulin resistance.Insulin resistance should play a significant role in the post-load HDL-C concentration after 75-goral glucose tolerance test.

This paper introduces the wavelet transform with multiresolution for liver cancer CT image enhancement. As the wavelet transform with compact support, orthogonality and approximately symmetry, SymletsA (sym4) wavelet family is applied to the two-layer multiscale decompose of the CT image. The decomposed wavelet coefficients are processed with the threshold values of 550, 350 and 250, with the low -frequency region intensified and the high-frequency one weakened. Then the image is reconstructed and thus the image is enhanced. Wavelet transform proves efficient in CT image enhancement.

Objective:To probe the correlation of intra-operative hyaluronic acid(HA) changes with hepatic allografts cold ischemia reperfusion injury in liver transplantation.Methods:The patients with orthotopic liver transplantation were assigned to 3 groups:① group A :liver allografts were stored in University of Wisconsin's solution(0℃) for 5-6 h before implantation;② group B :liver allografts were stored in U W's solution(0℃) for 8-9 h before implantation;③ group C :liver allografts were stored in U W's solution(0℃) for 12 h before implantation.The serum samples were taken up at 5 min,60 min,120 min,180 min after the donor liver was transplanted and reperfused to detect the concentration of HA.Results:After donor liver was transplanted and reperfused,serum HA concentration decreased immediately and gradually.HA decreased rate :group A 4.58 ?g/L?min-1,group B 4.16 ?g/L?min-1,group C 2.26 ?g/L?min-1.Serum HA decrease rate was faster in group A and B than that in group C(P

Objective To develop a kind of tongue image analysis instrument which is used to deal with the deviation problem on the process of tongue image analysis currently. Methods The system included two parts:hardware and software. The hardware was made up of special tongue image acquisition device and computer. With the application of digital image analysis technology, the instrument implements functions such as tongue image collection, image preprocess, image segmentation and feature analysis. Results After a certain amount of sample study process, the accuracy of tongue shape recognition was about 90%. Conclusion This instrument can achieve the aim of tongue information objectification and are widely used for clinical medicine and teaching.