OBJECTIVE:To investigate the status quo and tendency of the utilization of drug for bony metastasis cancer in our hospital. METHODS:The utilization of drug for bony metastasis cancer in our hospital from 2006 to 2009 was analyzed statistically. RESULTS:The total amount of the drug for bony metastasis cancer had been increasing. Pamidronate took up the first place of the consumption sum list and accounted for 80% of total consumption sum. Top one drug in the list of DDDs was domestical pamidronate. Utilization rate of disodium clodronate increased form 0.67% in 2006 to 31.68% in 2009. The order of DDC had not changed during 2006～2009. CONCLUSION:In recent year the drug for bony metastasis cancer has been rational and has become curative effect-oriented rather than price-oriented.

Establishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch. as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay.

Magnetic resonance imaging(MRI) has multi-faceted advantages due to its non-ionization radiation, excellent tissue contrast, high spatial resolution and multi-dimensional imaging technique. It can clearly observe the pathological changes of deseases, and judge for the prognosis. With the development of MRI, MRI has become increasingly popular in the diagnosis of fetal malformation. In this paper, it is described the value of MRd in the diagnosis, management and prognosis of fetuses malformations, via the central nervous system, circulatory system, respiratory system, digestive system, genitourinary system, musculoskeletal system, endocrine system, and so on.

Objective To study the the current situation of sexual for college students in luzhou area and to provide basis for their sexual health education .Methods 2 226 college students from four colleges in luzhou area were investigated by stratified clus-ter sampling method ,SPSS11 .5 software was used to analysis the results .Results 59 .62% of the students′knowledge was mainly from the media ,the test for sexual knowledge of college students′was satisfactory ;58 .94% of college students would like to com-municate and communication about sex and love ,84 .61% of the students thought that college students should have correct love and chastity view ,82 .95% of the students thought that should make efforts to prevent venereal disease and AIDS ,55 .27% of the students were firmly opposed to marriy during school study ;75 .15% of the students were firmly opposed to premarital sexual be-havior ,44 .44% of the students minded that lover once had sex ,36 .56% of the students broken up immediately when found that loveer had sex before .Conclusion The college students′sexual maturity in advance but knowledge of sex education relative lag , making them for many sexual problems and phenomena ,so scientific and systematic sexual health education should be strengthen in students .

Carcinoma ; pathology ; surgery ; Carcinoma, Papillary ; Humans ; Neck Dissection ; Thyroid Neoplasms ; pathology ; surgery

Objective To explore the myocardial damage and the changes of MB isoenzyme of creatine kinase(CK-MB) and cardial troponin I(cTnI) of rat with endotoxemia at early stage.Methods Sixty SD rats were randomly divided into lipopolysaccharide(LPS) group(LPS group,n=48) and control group(n=12).Rats in LPS group were injected intraperitoneally with LPS(5 mg/kg) and then divided into 6 subgroups according sacrificed time after injection(0.5,1.0,2.0,3.0,12.0,24.0 h).CK-MB/ cTnI in blood was determined with chemiluminescent technique and myocardial pathological damage was observed under the light and transmission electron microscope.Control group was subjected to normal sodium and divided randomly into the same subgroups too.Results The rat diminished their action after beening injected endotoxin 15 minutes,and their reaction were slow.One hour later,they were short of action and reaction.Three hours later,they almost did not move at all,and the glossiness of their pelage were faint.Twenty-four hours later,their foodintake was diminished,their shout were weakened,and their response to stimulus were very thin,the glossiness of pelage were insufficient.Compared with control group,CK-MB increased significantly at 1.0,2.0,3.0,12.0,24.0 h(Pa

Organic anion transporting polypeptides (OATP), a member of solute carrier (SLC) superfamily, is considered as an important transmembrane uptake transporters. OATP is involved in the transport of a variety of endo- and xenobiotics (bile acids, bilirubin, prostaglandin, thyroid hormones, steroid hormone conjugates), drugs and toxins in a Na+ and ATP independent manner. Multiple factors (eg. hormones, proinflammatory cytokines, drugs) can affect the distribution, expression and activity of OATPs, leading to an altered accumulation of OATP substrates and related food-drug and drug-drug interactions. Changes in the distribution and expression of OATPs in malignant tissues may be related to the pathological process of cancer, while the modulation epigenetic mechanism also contributes to its distribution patterns. This review describes the factors that can affect the expression or function of OATPs, which may provide a valuable reference for drug development and the clarification of pathogenesis.
Biological Transport ; Humans ; Neoplasms ; Organic Anion Transporters ; physiology ; Xenobiotics

As a functional membrane protein, drug transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The functional omission or inhibition of drug transporters is believed to be involved in the drug-drug interaction and pathogenesis of certain diseases. Understanding the function of drug transporters is highly significant in terms of pharmacokinetics, pharmacodynamics and toxicity of drugs. This article summarized the methods for the study of drug transporters in vitro and in vivo.
Biological Transport ; Drug Interactions ; Humans ; Membrane Transport Proteins ; metabolism