Objective To investigate the therapy effect and adverse reaction of the abraxane chemotherapy as a alternative plan in metastatic breast cancer.Methods Twenty-one patients with advanced metastatic breast cancer were selected as our subject.All the patients received rescue chemotherapy after relapse and metastasis.Abraxane were administrated with 260 mg/m2 3 weeks/time,and evaluated the effect in every two course of radiotherapy.Results Of 21 cases,4 cases were remission and 8 cases were with stable progress of cancer.No allergic reaction occurred.The majority adverse reaction were granulocytopenia and nerve toxicity.Conclusion Abraxane migh be considered as the altemate therapy medicine of metastatic breast cancer due to good curative effect,less toxicity reaction and no allergic reaction.

ObjectiveTo observe the effect of work simulated training for workers suffered from work-related injuries.Methods65 injured workers joined a 2.8-month (on average) training program by applying the BTE PRIMUS work simulated training system, with six-month follow up period after discharge.ResultsDuring the six-month follow up after discharge, 29(44.62%) workers returned to the same company with the same job,24(36.92%) workers returned to the same company but changed job,6 (9.22%)works changed company and changed job ,6(9.22%)works didn't return to work.ConclusionWork simulated training program can improve injured workers'working ability and help them return to work.

Objective To explore specific risk factors in the early seizures after acute moderate and severe head injuries and understand incidence of nonconvulsive status epilepticus (NCSE) under coma. Methods Eighty-six patients with acute moderate and severe head injuries were monitored with video-electroencephalogram (video-EEG) for one week. Results (1) Of all, 7 cases (8.14%) had clinical seizures and 6 (6.98%) NCSE. (2) In patients with severe head injuries especially intracranial hemorrhage, post-traumatic seizures especially NCSE were more likely to occur, with no significant difference in sex and age. Conclusions Severe and critical head injuries and intracranial hemorrhage are specific risk factors for early post-traumatic seizures, especially NCSE. After brain injury, EEG should be used to evaluate traumatic coma even if clinical seizure does not appear.

Objective To investigate the effect of lansoprazole injection on 24-hour intragastric pH in healthy volunteers. Methods The volunteers inclouding 10 women and 10 men, were divided into experitmental group and control group randomly, each group of 10 cases. After testing the pH initial value in stomach through pH determination electrode, the cases in experitmental group were drip the drug of lansoprazole injection, the cases in control group were drip the same volume of 0.9% sodium chloride solution. Then constantly determined the value of pH in the stomach for 24 h. Results The pH value in the stomach of expertimental group after injected lansoprazole was significantly higher than that before administration (P < 0.05). The pH value in the stomach of expertimental group was higher than that in control group between finished of injection and 24 h, especially in the first 12 h after administration, there were significantly differences (P < 0.01). The pH value in experimental group after injected lansoprazole for 24 h was 4.565 ± 1.109, in control group was 2.211 ± 0.263, there was significant difference (P < 0.01). The percentage of maintenance time of pH reaching 4.0 and 6.0 in stomach in experimental group were (73.36 ± 21.08)% and (53.22 ± 23.76)% , in control group were (13.28 ± 10.55)%and (3.92 ± 2.17)%, there were significant differences (P<0.01). Conclusions The strength of acid suppresion of lansoprazole injection is worthy of approving, and it can work at full capacity in treatment of patients with peptic ulcer complicated with upper gastrointestinal hemorrhage if lansoprazole is given every 12 h.

12 gestational-week uterus) were treated in our hospital by LAVH. The operation time,intraoperative blood loss,and postoperative recovery of the patients were compared to another 110 cases that underwent TAH. Results The operation time in the TAH group was significantly shorter than that in the LAVH group [(109?27) min vs (130?22) min,t=-6.441,P=0.000]. During the operation,the LAVH group had a mean of (121?70) ml blood loss,which was significantly lower than that in the TAH group [(141?73) ml,t=-0.903,P=0.368]. After the operation,the patients in the TAH group had longer recovery time for gastrointestinal function and longer hospital stay than those in the LAVH group [(45?13) h vs (24?6) h,t=15.778,P=0.000;and (7?2) d vs (5?2) d,t=7.530,P=0.000]. Conclusions Compared to TAH,LAVH results in shorter hospital stay and fewer postoperative complications. It is a feasible and safe treatment for large uterus.

Objective To investigate the effect of dexamethasone(DXM)and fructose-1,6-diphosphate(FDP)on cardial troponin I(cTnI)and MB isoenzyme of creatine kinase(CK-MB),and ultrastructure of myocardial cells in rats with endotoxemia.Methods Eighty SD rats were randomly divided into 4 groups:sodium chloride group(NS group,n=8),9 g?L-1 NS 1 mL,ip;lipopolysaccharide group(LPS group,n=24),administered with endotoxin(5 mg?kg-1,ip);DXM group(n=24):received DXM(5 mg?kg-1,ip)after injection of LPS 1 h;FDP(n=24)group,received FDP(1 g?kg-1,ip)after injection LPS 1 h.Then,they were sacrificed at 6 h,12 h,24 h and 72 h after injection.CK-MB and cTnI in blood were detected with chemiluminescent techniques,and myocardial pathological damage was observed under the light and transmission electron microscope.Results Compared with control group,in LPS group,the serum cTnI and CK-MB were increased significantly from 6 h to 24 h with time going by(P

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease with unknown etiology,including ulcerative colitis (UC) and Crohn’s disease (CD).At present,as the global incidence of inflammatory bowel disease is increasing year by year,the role of the intestinal micro ecology in disease evolution has attracted more and more attention,and as an important part of gut microbes system,the intestinal fungus'changes and effects in disease states are unclear.This paper reviews on the intestinal fungus in the occurrence,development of inflammatory bowel disease from the composition and distribution of the intestinal fungus and its relationship with the gut bacteria,and the immune reaction.

It is well established that renin-angiotensin system (RAS) is the major regulatory networkthat maintains blood pressure, fluid and electrolyte balance and the homeostasis of cardiovascular system.Most studies in the last decades centered on the pivotal members of RAS, that is, angiotensinⅡ (AngⅡ) and angiotensin converting enzyme (ACE). Recent identification of ACE-2, the homology of ACE,and the identification of the multiple products degraded from angiotensinⅠ, including AngⅢ, AngⅣ,Ang1 -9, Ang1 -7, Des-Asp-angiotensinⅠ(DAAⅠ), etc, have proved that AngⅡ is not the only bio-logical active compound of RAS. Peptides derived from angiotensinogen,that is, family of angiotensins,display independent and pleiotropic biological activitiesin vivo, and interact with each other both in me-tabolism pathway and the biologic effects. The imbalance of the network of angiotensin metabolites exhib-its significant pathophysiological role in cardiovascular disease.

Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition ; Humans ; MicroRNAs ; genetics ; metabolism ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms ; drug therapy ; genetics ; metabolism ; pathology ; Neoplastic Stem Cells ; metabolism ; pathology

Objective: To study the telomerase activity changes during the differentiation of human mesenchymal stem cells (MSCs) into adipocytes and the related mechanism. Methods: Human MSCs were isolated from human bone marrow by plastic adhesion and were characterized by immune phenotyping. The multilineage differentiation potential of MSCs was confirmed by inducing MSCs to differentiate into osteoblasts and neuron-like cells by corresponding agents. Telomeric repeat amplification protocol (TRAP) assay was performed to examine telomerase activity in MSCs during adipogenic differentiation of MSCs; Western blotting analysis was used to examine the protein expression levels of hTERT, TRF1, and Tankyrase 1. Results: TRAP showed that telomerase was negative in MSCs, but greatly up-regulated during the adipogenic differentiation process, peaked on the 7th day after adipogenic differentiation of MSCs(P<0.05), and then decreased thereafter. Western blotting analysis showed slight hTERT expression in MSCs, and the expression of hTERT and Tankyrase 1 increased during the adipogenic differentiation process, peaked on the 7 th day, and gradually decreased thereafter. The expression of TRF1 remained unchanged. Conclusion: Telomerase is weakly expressed in MSCs; the expression is increased during the adipogenic differentiation process of MSCs and then gradually decreases; and Tankyrase 1 may play an important role during the process.