150 slides of vaginal sample of married women aged 16-49 years old at 8 village of Ha Tay province were investigated. In 51.6% of subjects, there is not pathological manifestation in 48.3% - inflammative damages, then 38.6% with chronical manifestation and 12.6% with acute PaP1 account for 62.6%, PaP2: 24.5% and PaP3: 0.13%. There is not any cancerous damage. Hygiene condition, obstetrical history and venerological diseases were factors related to inflammative state and cervix cell morphology change
Women ; epidemiology ; Cervix Uteri ; cells

From 1996 to 2000, 73 samples of renal biopsy in patients >16 years old with glomerulonephritis and nephrotic syndrome were study on light microscopy. Results: the rate of minimal change glomerulopathy was highest (72.6%), then was the rate of diffuse mesangial proliferative glomerulonephritis (20.6%). The rates of focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, and membranous glomerulonephritis in this study were lower than the other studies. The changes in minimal change glomerulopathy are glomerular basement membrane thickened irregularly, widening and effacement of the visceral epithelial cell foot processes
Glomerulonephritis, Membranous ; Nephrotic Syndrome ; Patients

Objective To observe the clinical efficacy of ear acupuncture combined with mirtazapine in the treatment of insomnia.Methods Sixty-two patients with insomnia diagnosed by CCMD-Ⅲ were randomly divided into two groups,31 patients in each group.The patients in the observation group were treated by ear acupuncture combined with mirtazapine,and the patients in the control group were treated by mirtazapine.The clinical efficacy was evaluated by SDRS after 4 weeks of treatment.Results The SDRS score of the observation group significantly decreased after one week of treatment [(13.40±5.79)points vs.(21.79±6.12)points,t=2.204,P＜0.05].The SDRS score of the control group significantly decreased after one week of treatment [(14.68±5.88)points vs.(22.67±6.06)points,t=2.198,P＜0.05].After 4 weeks of treatment,the clinical efficacy of the observation group was significantly better than that of the control group (z=-2.209,P＜0.05),the SDRS score of the observation group was also significantly better than that of the control group (t=2.163,P＜0.05).Conclusion Ear acupuncture combined with mirtazapine has better effect in the treatment of insomnia patients,it has less side effects and lasting effects.

Concept-map can be seen as supplementary tool and strategy for teaching and learning of English writing,in addition,that can help the student open their mind,organize the article,inspire their creativity and cultivate the habit of English thinking,the purpose of that is improvement of writing level.

Teaching quality is the basis of higher education.This article compared the results of teaching supervision and evaluation between campus and affiliated hospitals of Qiqihar Medical University in 2011.Differences were found out and corresponding strategies were proposed in order to improve the teaching quality and train high-quality talents.

Surgical therapy should be the main method in treatment of rectal cancer.Along with the increase rate of undergoing anterior resection for rectal cancer,it is getting be paid more and more attention on postoperative anastomotic fistula as the main complications of rectal carcinoma.In recent research,anastomotic fistula occurred caused by various factors had also been put forward gradually,while the risk factors for postoperative anastomotic fistula were still remain unclear.Therefore,it is very important to understanding the risk factors in order to prevent the happening of the anastomotic fistula,and provide clinical basis for their necessary preventive colostomy.

Objective To analyze the clinical efficacy of diacerein plus methotrexate and leflunomide in the treatment of rheumatoid arthritis in elderly patients.Methods Eighty elderly patients with rheumatoid arthritis seeking treatment at our hospital from September 2010 to December 2012 were divided into the treatment group (n =40) and the control group (n =40).Patients with osteoarthritis were excluded from enrollment.The treatment group was given diacerein,in addition to methotrexate and leflunomide,whereas the control group received methotrexate and leflunomide.Results Compared with the control group,the treatment group showed a lower swollen joint count [(0.93±0.21) vs.(3.43±0.69),t=10.728,P=0.013],a lower tender joint count [(1.15±0.46)vs.(3.6110.83),t=11.443,P=0.008],shorter morning stiffness (1.6±2.2 min vs.13.5±4.2min,t=11.164,P=0.011),and greater hand grip strength [7.97±1.53) kPa vs.(5.68±2.07)kPa,t=10.562,P=0.014].When measured by health assessment questionnaire (HAQ),visual analogue scale (VAS) and DAS28 scores,the treatment group also performed better than the control group.Additionally,the treatment group displayed a more favorable laboratory profile,which included the erythrocyte sedimentation rate (ESR) (9.51±4.32 mm/h vs.26.47±6.32 mm/h,t=9.892,P=0.028),C-reactive protein (CRP) [(2.34±0.57) mg/L vs.(8.13±2.14) mg/L,t=9.427,P=0.031],and rheumatoid factors (RF) [(231.3±45.5) kU/L vs.(283.3±68.4) kU/L,t=10.023,P=0.018].Furthermore,the adverse reaction rate was significantly lower in the treatment group than in the control group (15.0％ vs.37.5％,x2 =5.230,P=0.020).Conclusions Diacerein in combination with methotrexate and leflunomide has shown clearly positive outcomes in the treatment of rheumatoid arthritis in elderly patients and should be recommended in clinical treatment.

The advances in domestic knowledge service ability were outlined from the aspects of its concept, constitutional elements, construction and assessment based on an analysis of papers on knowledge service ability covered in CNKI.The related problemsand certain aspects that need to be further studied were pointed out.

P13K/Akt signaling pathway is an classic anti-apoptotic,urge-survival signal transduction pathway.It plays important regulation and control roles in neurons apoptosis.PTEN ( phosphatase and tensin homolog deleted on chromosome 10) is a highly conservative tumor suppressor gene with a dual-specificity phosphatase activity.PTEN protein can specifically dephosphorylats the 3 position of phosphoinositides,antagonize the PI3K/Akt signaling pathway,as negativity regulation and control roles to cell survival and growth.This review summarizes the progresses of the composition,function in PI3 K/Akt and PTEN,and the relationship with developing brain after hypoxia-ischemia.

High mobility groupbox 1 (HMGB1),a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription,was recently found to act as a potent proinflammatory cytokine during infection responses.Levels of HMGB1 increase in serum and tissues during infection,especially in sepsis.A growing number of studies have demonstrated that HMGB1 is a cytokine that can mediate inflammation and is a potential therapeutic target in experimental models of sepsis.In this article,we will describe the biological function of HMGB 1 and HMGB 1 inhibitors for a potential role of inflammatory disease treatment.