4.Study on the inflammed fenomena and the cervical cell changes of 1520 women from 16-49 years old at 8 villages of Ha Tay province
Journal of Practical Medicine 2003;456(7):25-27
150 slides of vaginal sample of married women aged 16-49 years old at 8 village of Ha Tay province were investigated. In 51.6% of subjects, there is not pathological manifestation in 48.3% - inflammative damages, then 38.6% with chronical manifestation and 12.6% with acute PaP1 account for 62.6%, PaP2: 24.5% and PaP3: 0.13%. There is not any cancerous damage. Hygiene condition, obstetrical history and venerological diseases were factors related to inflammative state and cervix cell morphology change
Women
;
epidemiology
;
Cervix Uteri
;
cells
5.Renal interstinal tissue lesion in glomerulopathy with primary nephrotic syndrome in adults patients
Journal of Practical Medicine 2003;458(8):23-24
From 1996 to 2000, 73 samples of renal biopsy in patients >16 years old with glomerulonephritis and nephrotic syndrome were study on light microscopy. Results: the rate of minimal change glomerulopathy was highest (72.6%), then was the rate of diffuse mesangial proliferative glomerulonephritis (20.6%). The rates of focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, and membranous glomerulonephritis in this study were lower than the other studies. The changes in minimal change glomerulopathy are glomerular basement membrane thickened irregularly, widening and effacement of the visceral epithelial cell foot processes
Glomerulonephritis, Membranous
;
Nephrotic Syndrome
;
Patients
6.Composition, function in PI3K/Akt and PTEN, and the relationship with developing brain after hypoxiaischemia
International Journal of Pediatrics 2012;39(1):20-22
P13K/Akt signaling pathway is an classic anti-apoptotic,urge-survival signal transduction pathway.It plays important regulation and control roles in neurons apoptosis.PTEN ( phosphatase and tensin homolog deleted on chromosome 10) is a highly conservative tumor suppressor gene with a dual-specificity phosphatase activity.PTEN protein can specifically dephosphorylats the 3 position of phosphoinositides,antagonize the PI3K/Akt signaling pathway,as negativity regulation and control roles to cell survival and growth.This review summarizes the progresses of the composition,function in PI3 K/Akt and PTEN,and the relationship with developing brain after hypoxia-ischemia.
7.Progress of high mobility group box 1 protein and sepsis
International Journal of Pediatrics 2012;39(2):170-173
High mobility groupbox 1 (HMGB1),a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription,was recently found to act as a potent proinflammatory cytokine during infection responses.Levels of HMGB1 increase in serum and tissues during infection,especially in sepsis.A growing number of studies have demonstrated that HMGB1 is a cytokine that can mediate inflammation and is a potential therapeutic target in experimental models of sepsis.In this article,we will describe the biological function of HMGB 1 and HMGB 1 inhibitors for a potential role of inflammatory disease treatment.
8.P-glycoprotein expression in lung cancer and progress in cisplatin resistance
Cancer Research and Clinic 2011;23(8):565-567
Cisplatin is widely used in lung cancer chemotherapy, but drug resistance seriously affects its efficacy.The mechanism of cisplatin resistance is not yet clear.Now it is widely recognized that P-glycoprotein (P-glycoprotein, P-gp) expression is associated with cisplatin resistance. Inhibition of P-gp expression can overcome cisplatin resistance and improve the treatment efficacy.
9.Relationship between the physical and chemical properties of calcium phosphate ceramics and the host tissue
International Journal of Biomedical Engineering 2001;24(2):81-85
Calcium phosphate ceramics, such as tricalcium phosphate (TCP) and hydroxyapatite (HA) are commonly used as bone substitutes. These materials have different physical and chemical properties and, therefore, display different interactions with the host tissue. Factors such as porosity,osteoconductivity,and biocompatibility seem to become increasingly important in the development of new artificial bone replacement materials. This article focuses on the relationship between the physical and chemical properties of calcium phosphate ceramics and the host tissue.
10.Papers on reading popularization from 2002 to 2012:A bibliometric analysis
Chinese Journal of Medical Library and Information Science 2014;(2):63-67
Papers on reading population in domestic library and information field from 2002 to 2012 were retrieved.Its status quo, academic achievements and inadequacies were analyzed by bibliometrics and suggestions were put for-ward for reading population, such as further dividing its research subjects, strengthening its innovative research, and establishing its assessment system.