Objective To describe the high-resolution CT(HRCT)findings of arc-welders with early pneumoconiosis and to evaluate manifestation in different course of disease.Methods Seventy-six arc-welders with a one to thirty-eight(mean,14)years history of exposure underwent CT and HRCT scanning.The extent of abnormalities were detected.The relations of age and year history of exposure were analysed in different groups.Results Thirty-eight welders(38/76,50%)showed positive characteristic findings with conventional CT.Predominant thin-section CT findings were poorly-defined centrilobular micronodules(18/76,23.7%),branching linear structure(20/76,26.3%).The mean age in group of branching linear structure[(39±9)years old]was elder than of poorly-defined centrilobular micronodules[(34±7)years old].There was no statistical difference between the two groups(t=-1.648,P＞0.05).The mean length of service at exposure in group of branching linear structure[(15±8)years]was longer than of poorlydefined centrilobular micronodules[(10±5)years].And the significant differences were showed between the two groups in the year history of exposure(t=-2.108,P＜0.05).Conclusions Poorly defined centrilobular micronodules and branching linear structures were the thin-section CT findings most frequently seen in patients with arc-welders'pneumoconiosis and the former may be one early stage characteristic finding of arc-welders'pneumoconiosis.HRCT is useful in achieving more accurate categorization of the parenchymal changes in arc-welders'pneumoconiosis.

Objective To investigate the safety and effects of probiotics and oral scaling in the treatment of patients with chronic atrophic gastritis .Methods 180 patients with chronic atrophic gastritis were chosen as study objects.The patients were randomly divided into control group and research group according to the digital table ,with 90 cases in each group .The control group received sequential therapy and oral scaling ,the research group was given oral scaling combined with probiotics.After treatment for 3 months,the clinical effects,symptom score,pathology score,Hp clearing rate and adverse reaction between the two groups were compared.Results The total effective rate of the research group(92.22%) was higher than that of the control group (82.22%),the difference was statistically significant (χ2 =4.038,P<0.05).The gastric Hp eradication rate of the research group (96.67%) was higher than that of the control group(86.67%),the difference was statistically significant (χ2 =5.891,P<0.05).There was no statistically significant difference in positive rate of oral Hp between the two groups (P>0.05).Before treatment,the symptom score and pathology score between the two groups had no statistically significant differences (all P >0.05).After treatment,the symptom score and pathology score of the research group were ( 6.41 ±1.09 ) points, ( 5.46 ± 0.94)points,respectively,which were significantly lower than those of the control group [(7.56 ±1.18) points, (8.12 ±1.04) points],the differences were statistically significant (t =8.026,9.843,all P <0.05).7 cases (7.78%) of adverse reaction occurred in the research group ,and 5 cases(5.56%) in the control group,the differ-ence was not statistically significant between the two groups (χ2 =0.357,P >0.05).Conclusion Probiotics combined with oral scaling on the basis of sequential therapy in the treatment of patients with chronic atrophic gastritis can effectively improve the Hp clearing rate and clinical symptom ,and with good effects and safety .

OBJECTIVETo observe the effects of manganese sulfate on blood pressure, myocardial ultrastructure and heart organ index of rats.

METHODSForty male SPF SD rats were randomly divided into 4 groups: control group (0 mg/kg), 5 mg/kg dose group, 15 mg/kg dose group and 25 mg/kg dose group, 10 rats each group. Intraperitoneal injection was performed for six months, by five times each week, the rat blood pressure was measured by tail cuff method, and the heart organ index of the rats was computed. Three rats were selected from each group randomly, and the myocardial ultrastructure of the rats was observed by using transmission electron microscopy (TEM). The BMD and BMDL between manganese sulfate injected dose and the rats heart organ index were evaluated by BMD (Benchmark Dose).

RESULTSThere was no significant of blood pressure between the experimental group and the control group (P > 0.05).The heart organ indexes of the four groups were 0.24% ± 0.10%, 0.25% ± 0.02%, 0.26% ± 0.02%, and 0.24% ± 0.02%. Statistical significance of heart organ indexes was found between the 15 mg/kg dose group and the control group (P < 0.05). Observed by TEM, we found that-different degrees of mitochondrial crest fracture or disappear, mitochondria swelling, hydropic change and myocardial fibers degeneration happened in the rats of the three exposed groups, but not the control group. The BMD and BMDL were calculated as 9.33 mg/kg and 4.28 mg/kg in the study of manganese sulfate injected dose and the rats heart organ index.

CONCLUSIONChronic manganese poisoning can lead to myocardial mitochondria superfine lesions, myocardial fiber damage and heart organ index change in rats.

Animals ; Male ; Manganese Compounds ; Mitochondria ; drug effects ; ultrastructure ; Myocardium ; ultrastructure ; Myocytes, Cardiac ; drug effects ; ultrastructure ; Rats ; Rats, Sprague-Dawley ; Sulfates ; toxicity ; Toxicity Tests