1.Finite element analysis of the effects of individual extralevator abdominoperineal excision for rectal neoplasms below levator hiatus on pelvic floor
Jia LIU ; Jiefu WANG ; Dalu KONG ; Lei ZHENG ; Dongzhi HU ; Jiansheng GUO
Tianjin Medical Journal 2017;45(9):935-939
Objective To evaluate the effects of individual extralevator abdominalperineal excision (ELAPE) for rectal neoplasms below levator hiatus on pelvic floor by finite element analysis. Methods MIMICS 10.01, GeoMagic Studio 12 and ANSYS Workbench 14.0 were used to deal with magnetic resonance data of 27 healthy nulliparous volunteers'pelvic, and then three types of finite element models were developed:intact models, ELAPE models and individual ELAPE models. The maximum stress in non levator ani tissue under the same load were measured in three types of models, and levator ani 's maximal stresses were measured in intact model and individual ELAPE and their stress distributions under the same pressure were analyzed and compared. Results The maximal stresses of non-levator ani tissue were (1.963±0.061) MPa, (5.127±0.070) MPa and (4.703±0.110) MPa for intact model, ELAPE model and individual ELAPE model respectively. The maximal stress was lower in individual ELAPE model than that in ELAPE model, but which was higher than that of intact model (P<0.01). The high-stress zone was found at the joints with surrounding structures on both sides of intact model and ELAPE model. The high-stress zone was found in front of the joints with surrounding structures on both sides in individual ELAPE model. The maximal stresses of three types of models were found in front of both sides. In intact model levator ani 's maximal stress was (0.812 ± 0.042) MPa, which was higher than that of individual ELAPE model (0.719 ± 0.027) MPa (P<0.01). The high-stress zone of intact model was found in front of the joints on both sides. The maximal stress was showed at ventral ends on both sides. For the individual ELAPE model the high-stress zone was found at the anterior part of the levator ani muscle and the surrounding structure. The maximum stress appeared at the top end of the left and right sides. Conclusion This individual ELAPE is able to decrease the stress of non-levator ani tissue, which suggests that the risk of postoperative pelvic floor hernia is relatively reduced.
2.Surgical treatment of multiple primary colon cancer in aged patients
Qinghao CUI ; Dalu KONG ; Dianchang WANG ; Ning LIU ; Xuewei DING ; Yi DONG
Chinese Journal of Geriatrics 2001;0(01):-
Objective Summarize the experience in the surgical treatment of multiple original colon cancer in aged patients. Methods The retrospective analysis was performed in the 46 cases of multiple original colon cancer in aged patients in our hospital from August 1955 to May 2000. Results The 46 cases of multiple original colon cancer in aged patients account for 7.6% (46/608) of the total cases of colon cancer in patients in the same period. There were 26 cases of the male and 20 cases of the female. 30 cases were colon cancer with tumors from other organs. "The different time cancer" could be found 31 years later. The follow-up rate was 100%. The survival rates for 3,5,10,15,20 years were 71.1%(27/38), 63.6%(21/33), 43.3%(13/30), 28.6%(8/28) and 16.0%(4/25) respectively. In this study, we found that the survival rate of the group was higher than that of the aged patients suffering colon cancer in the same period of time. Conclusions The number of multiple original colon cancer in aged patients has been increased in the decade. The incidence was 43.5% (20/46) in the study. With the development of society, both doctors and patients have improved their knowledge about multiple original carcinomas in aged patients. The positive rate of early diagnosis was promoted to a high level, especially in the monitor and treatment of per operation. Choosing the energetic operation, we will acquire the better therapeutic efficacy for treatment of multiple original cancer in aged patients.
3.Surgical treatment of posterior pilon fracture through the posteromedial approach
Hongbin ZHANG ; Jie CHEN ; Pengfei GUAN ; Lifeng ZHANG ; Dalu WANG ; Jianjun LI ; Hailin XU
Chinese Journal of Orthopaedic Trauma 2016;18(3):214-219
Objective To review the results and complications of open reduction and internal fixation (ORIF) through the posteromedial approach for posterior pilon fractures.Methods From March 2009 through November 2013,18 consecutive posterior pilon fractures were surgically treated through the posteromedial approach,involving 12 males and 6 females.Their ages ranged from 15 to 65 years (average,42 years).All of them were complicated with fracture of external malleolus,and 6 of them with fracture of anterior colliculus of medial malleolus.The time from injury to surgery ranged from 2 to 15 days (average,7 days).Results The patients were followed up for an average of 15 months (range,from 10 to 19 months).All the fractures healed after 11 to 16 weeks (average,13 weeks).No complications like neurovascular injury,implants failure,nonunion,or malunion occurred,except one case of superficial wound infection which responded to nonoperative management.According to the AOFAS (American Orthopaedic Foot and Ankle Society) evaluation system,15 cases were excellent,2 cases good and one case fair.Conclusion It is safe,reliable and effective to treat posterior pilon fractures using anti-rotation plate ORIF through the posteromedial approach.
4.Monitoring myocardial ischemia by EASI-derived 12-lead electrocardiogram in orthopaedic surgery
Litao ZHANG ; Jingmei ZHANG ; Guohua ZHANG ; Donghong YANG ; Jinsong LI ; Sufen CAI ; Dalu WANG ; Fan YI ; Yuguang WANG
Chinese Journal of Postgraduates of Medicine 2008;31(15):24-26
Objecfive To investigate possibihty of monitoring myocardial isehemia by eontinuous EASI 12-lead ST-segment trend analysis during orthopaedic surgery and find its rules.Methods Three hundred and eleven consecutive patients who underwent orthopaedic surgery were monitored bv continuous EASI 12-lead ST-segment analysis during surgery.Results Among 311 patients 81 patients(26.0%) had myocardial ischemic events.The ischemie incidence of general anesthetics WaS signifieantly higher than local anesthetics(the spinal or epidural anesthetics and nerve-block anesthetics)(38.1%vs 23.0%.P= 0.01 5).During ischemie events the patients whose heart rate exceeded 90 beat per minute was 71.6% (58/81).Among the 177 isehemie events,the duration ofless than 5 minutes was 79.7%(141/177).ST-seg- ment deviation ofless than 0.15 mV was 71.2%(126/177).Conclusions During orthopaedic surgery EASt 12-lead electrocardiogram is the optimal approach for monitoring myocardial isehemia.The ischemic incidence of general anesthetics is significantly higher than local anesthetics.The myocardial ischemia events correlates with fast heart rate.The intraoperative myocardial ischemia events are more often transient.In most of these ischemic events ST-segment deviation is not very serious.
5.Nonlinear analysis of multi-channel EEG and its application to mental workload detection.
Dalu LIU ; Zhaohui JIANG ; Huanqing FENG ; Guoyan WANG
Journal of Biomedical Engineering 2006;23(5):960-963
Mental workload research is important to people's health and work efficiency, Psychophysiological measures such as electroencephalography (EEG), ECG and respiration measures can be used to predict mental workload level. A Multi-channel phase-space reconstruction method is proposed in this paper which rearranges signal serials by the correlation coefficients and select time delay by signal determinism. The study of determinism and correlation dimension on simulative data exhibits a good performance. The result of EEG series shows a clearly consistency to workload level variety. The method is useful for multi-channel signals nonlinear analysis and mental workload detection.
Adult
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Algorithms
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Electroencephalography
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Humans
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Mental Processes
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physiology
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Nonlinear Dynamics
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Signal Processing, Computer-Assisted
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Task Performance and Analysis
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Workload
6.Analyzing sleep EEG using correlation dimension and approximate entropy.
Zhaohui JIANG ; Huanqing FENG ; Dalu LIU ; Tao WANG
Journal of Biomedical Engineering 2005;22(4):649-653
Correct sleep scoring is the base of sleep studying; nonlinear features of EEG can represent different sleep stages. In this paper, correlation dimension (D2) and approximate entropy (ApEn) of sleep EEG have been calculated. The statistical results reveal that: D2 does not come to be saturated when the embedding dimension increases, but the relative value of D2 can effectively distinguish different sleep stages. ApEn has the advantage of calculating simply, steady result and representing preferably different sleep stages. ApEn and the relative value of D2 reveal, from different point of view, the same rule about EEG (brain) complexity changing, that is, both complexity and its fluctuation are maximal in the subject's awake hour, are decreasing with the deepening of sleep, but the complexity in REM is about the level between S1 and S2.
Electroencephalography
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Entropy
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Humans
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Nonlinear Dynamics
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Sleep
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physiology
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Sleep Stages
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physiology
7.Diagnosis and treatment of primary gastric non-Hodgkin's lymphoma: analysis of 157 patients.
Qinghao CUI ; Xuebin DONG ; Dianchang WANG ; Xishan HAO ; Jiacang WANG ; Qiang LI ; Dalu KONG ; Ning LIU
Chinese Journal of Preventive Medicine 2002;36(7):502-504
OBJECTIVETo seek the optimum treatment for patients with primary gastric non-Hodgkin's lymphoma and factors associated with prognosis.
METHODSA retrospective study was conducted on 157 primary gastric non-Hodgkin's lymphoma patients who had received operation for 45 years.
RESULTSThe X-ray diagnosis rate was 39.4% before operation. The diagnosis rate by gastroscopy was 52.7%. Among the 157 patients, 32 belonged to stage I(E), 40 stage II(E), 29 stage III(E), and 56 stage IV(E). All of the patients were received chemotherapy or radiation. The 3-, 5-, 10-, 15-year survival rates were 51.1% (69/135), 42.3% (55/130), 20.7% (23/111), and 13.5% (14/104).
CONCLUSIONSThe 3-, 5-year survival rates in stage I(E) and stage II(E) were 2 to 5 times higher than those in stage III(E) and IV(E) (P < 0.01). The 3-, 5-year survival rates of primary gastric non-Hodgkin's lymphoma were 60.2% (65/108) and 50.0% (52/104) respectively. The prognosis was better than the 5-year survival rate of gastric cancer patients with D(2) lymphodenectomy (33.3%). Early diagnosis and treatment are effective to prevent complications, enhance quality of patient's life, and prolong the survival.
Humans ; Lymphoma, Non-Hodgkin ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate
8.Updates and prospect of da Vinci robotic surgical system in radical resection of colorectal cancer
Sizhe TANG ; Pu WANG ; Dalu KONG
Chinese Journal of Clinical Oncology 2019;46(7):370-374
Introduction of the da Vinci robotic surgical system has revolutionized the field of minimally invasive surgery. Innovative ro-botic technologies have helped surgeons overcome the technical difficulties of conventional laparoscopic surgery. At present, da Vinci robotic colorectal surgery is a safe and feasible option and has shown comparable short-term outcomes with conventional laparoscop-ic surgery. However, it has no oncological advantage despite its significantly higher cost. Promising technologies have been developed to overcome the drawbacks and obstacles of the current robotic systems. Moreover, further randomized controlled clinical trials are re-quired to assess the long-term results and potential benefits of robotic surgery over laparoscopy. This review aimed to elucidate the current developments in robotic colorectal surgery and to explore emerging surgical robotic technologies currently available or in de-velopment.
9.Clinicopathological characteristics and prognosis of patients with centrally located hepatocellular carcinoma in different risk levels
Tian FEI ; Wang JIEFU ; Zhan YANG ; Liu JIA ; Wu JIANXIONG ; Kong DALU
Chinese Journal of Clinical Oncology 2018;45(22):1133-1141
Objective: To analyze clinical features and prognosis of hepatocellular carcinoma (cHCC) patients after liver resection, so as to clarify the prognostic risk factors. Methods: We retrospectively reviewed the data of patients who underwent mesohepatectomy for cHCC at Tianjin Medical University Cancer Hospital and Chinese Academy of Medical Sciences Cancer Hospital between October 2006 and December 2014. The patients were assigned into three subgroups according to disease-free survival (DFS): high risk (DFS≤1 year), middle risk (1 year
10.Research Status of Deubiquitinating Enzymes and JOSD2 in Malignant Tumors
Wenpeng WANG ; Dan SHI ; Duo YUN ; Dalu KONG ; Jiefu WANG
Cancer Research on Prevention and Treatment 2024;51(5):392-396
Ubiquitination is a crucial post-translational modification process that can degrade proteins within cells and plays a vital role in maintaining protein homeostasis and abundance. Deubiquitinating enzymes (DUBs) are important proteases in the ubiquitin system. They reverse the ubiquitination process by cleaving protein chains and recycling ubiquitin molecules to regulate protein stability. Abnormal deubiquitinating enzyme activity is related to the occurrence and development of many malignant tumors. JOSD2, a DUB, is a member of the Machado-Joseph disease protein domain protease (MJD) family and characterized by a single highly conserved catalytic Josephin domain. Increasing studies have revealed a connection between JOSD2 and malignant tumors. This article elaborates on the current research status of DUBs, particularly JOSD2, in malignant tumors. Results suggest that JOSD2 is a potential target for the treatment of malignant tumors.