Object To study the effect of bismuth potassium glycyrrhizate on gastric ulcers in rat. Methods Area of ulcer, gastric juice volume, acidity and pepsin output were measured on experimental gastric ulcer induced by acetic acid, stress and pyloric ligation in rats. Results Bismuth potassium glycyrrhizate was shown to be able to reduce areas of ulcers, gastric juice volume, acidity and pepsin output. Conclusion Bismuth potassium glycyrrhizate had antiulcer effect in rats.