Objective To study and analyze the clinical efficacy of metoprolol combined with trimetazidine in the treatment of coronary heart disease and heart failure. Methods 80 patients with coronary heart disease and heart failure treated in our hospital from January 2015 to December 2016 were selected and randomly divided into the control group and the experimental group, with 40 cases in each group. The control group received routine treatment, including diuretics and angiotensin converting enzyme inhibitors, and the experimental group was treated with trimetazidine combined with metoprolol. The therapeutic effects of the two groups were compared and analyzed. Results After the corresponding treatment, 5 patients in the experimental group were invalid. In the control group, 14 patients were ineffective. The effective rate of treatment in the experimental group (87.5％) was significantly higher than that in the control group (65.0％), the differences were statistically significant (P<0.05). After treatment, the LVEF in the experimental group was (50.4 ± 7.7)％, and the LVEF in the control group was (45.1 ± 7.0)％. In addition, the LVEDD and LVESD indexes and LVEF in the experimental group were better than those in the control group, the differences were statistically significant (P<0.05). Conclusion The clinical effect of trimetazidine combined with metoprolol in the treatment of coronary heart disease and heart failure is better. It can improve the efficiency of treatment to some extent, and has the significance of further promotion and application.

By taking advantage of gene engineering,recombinant calcitonin analogue can be successfully obtained.This method can greatly improve the biological activity of the analogue of calcitonin and lower its antigenicity.In this review we discuss the recent progress in the production of recombinant human calcitonin.

Objective To investigate the effect of granulocyte-macrophage colony-stimulating factor(GM-CSF) on rat calcitonin(CT).Methods A total of 48 SD healthy rats were randomly divided into control group,low GM-CSF(10?g/kg?d) and high GM-CSF dosage(50?g/kg?d) groups.The rats in experimental groups were continuously treated by an intraperitoneal application of GM-CSF for over 7 days.The level of calcitonin was measured by radioimmunoassay(RIA),and the serum calcium(Ca),ALP and phosphorus(P) were examined by biochemical method.Results The level of the serum calcium in high-dosage GMCSF group was lower than that in the control group(P0.05).Conclusion The high dosage GM-CSF can decrease the serum calcium;the low-and high-dosage GM-CSF can decrease the serum calcitonin,but has no effect on the level of serum phosphorus and ALP.

Background and purpose:Advanced pancreatic cancer is characteristic of poor treatment eff icacy and short survival time. Gemcitabine is considered as front-line therapy for advanced pancreatic cancer. Gemcitabine combinations have shown a favorable impact on survival. We compared gemcitabine-based combination cheme therapy and gemcitabine(GEM) alone in patients with advanced pancreatic cancer through Meta analysis in phase Ⅲ clinical trials. Methods:MEDLINE and EMBASE searches were supplemented by information from trial registers of phase Ⅲ randomized controlled trials(RCTs) for GEM-based combination therapy and GEM alone for advanced pancreatic cancer. A quantitative meta-analysis was carried out by two reviewers based on the inclusion criteria from all available RCTs. The Meta-analysis involved 6-months and 1-year survival rate and objective remission rate(ORR) . Results:The Meta-analysis included 20 RCTs. The result of our Meta-analysis showed that there was signifi cant improvement in the GEM combination group with regard to the 1-year survival rate(RR:0.87,95%:(0.78,0.96) ,P=0.008) . The other result of our meta-analysis showed no signifi cant difference between two groups. Conclusion:GEM-based combination therapy may be effective with regard to the survival rate compared with GEM alone.

Objective To select the intravenous anesthetic with less effects on the erythrocyte immunity,and observe regulation of ?-endorphin on erythrocyte immunity in vivo Methods Seventy-two mice were randomly allocated to receiving intraperitoneally normal saline 0 04ml/g (group I,n=13), thiopental sodium 60mg/kg (groupⅡ,n=10),etomidate 20mg/kg (groupⅢ,n=10),etomidate -lipuro12mg/kg (groupⅣ n=9), midazolam 20mg/kg (groupⅤ,n=12),fentanyl 100?g/kg (groupⅥ,n=10) or pethidine 20mg/kg (groupⅦ,n=10) at 9 o'clock in the morning ,respectively and were administered at half dosage at 3 o'clock in the afternoon At 9 o'clock of the next day.Results Compared with those in group Ⅰ, the rosette rate of RBC-C3b receptor(RC3bRR) decreased significantly in group Ⅱ, Ⅳ,Ⅴ and Ⅶ(P

Objective To explore the clinical and radiological findings of skeletal desmoplastic fibromas.Methods Radiographs of six patients with desmoplastic fibromas proved by pathology were retrospectively reviewed.Results Two tumors arose in femur,two in tibia,one in radius and one in humur.In plain radiography,these lesions were always metaphyseal and expansile lytic with a reactive bony rim(n=6).They often had a trabeculated or honeycomb appearance into lesion and four tumors invaded adjacent soft tissue.Conclusion Desmoplastic fibromas of long bones are nearly always metaphyseal.Radiographs disclose a expansile lytic lesion with a sclerotic rim and a trabeculated apperance into it.And the "root hair"sign is fairly characteristic for this tumor.No calcification and periosteal reaction can be seen.

Objective To discuss the endothelial cell which was modified by exogenous anticoagulant genes contribute to the increase of antithrombosis activity of lined vascular prosthesis and the influence to other physiological functions of endothelial cells. Methods This summarized paper was made on literature review of recent years.Results The transfection of genes, including plasminogen activator (t-PA, u-PA, Urokinase), thrombomoduline (TM) and hirudin, etc, to endothelial cells resulted in not only the increase of antithrombosis activity of local vascular, but also the decrease of endothelial cell function in adherence and proliferation.Conclusion The increase of antithrombosis activity of lined vascular prosthesis has been done by exogenous genes. However, this technique ought to be studied, intensively.

AIM: To investigate the effect of nerve growth factor (NGF) on auditory and cochlear damage induced by brain ischemia and reperfusion. METHODS: The rats with brain ischemia and reperfusion were divided into two groups at random. In the experimental group, the rats were injected intramuscularly with NGF . In control group, the animals were injected with normal saline instead of NGF. Then the hearing loss and cochlear structural changes of rats in both groups were compared. RESULTS: It was found that the hearing loss of rats in NGF group were less significantly than that of control group ( P

After ig and iv 3H-berberine in rabbits, the plasma radioactivity-time cure was found to be 2-compartment open model. The pharma-cokinetic parameters were: T1/2B 35 .3?1 .3h ( ig ) and 35.8 ? 2.0h (iv), Vd 20 ?3 L/kg(ig) & 22.1?1.7 L/kg ( iv ) . 3H-berberine was rapidly absorbed & taken up by various organs . The highest radioactivity was found in lung, followed by liver, spleen & heart. The rate of binding with plasma protein was 38 ? 3 % . In 6 d cumulative excretion of radioactivity was 73% of total dose in urine & 10.9% in fe-ces . 3H-berberine was excreted mainly in unchanged form, as measured by TLC & liquid scintillation counting in urine & bile.

Objective To investigate the effect of glutamine intensified TPN on nutritional state and immunofunction in the postoperative patients with gastrointestinal tract tumour.Methods 20 patients were divided into two groups including standard TPN group (control group,10 cases) and Glutamine intensified TPN group(study group,10 cases). Period of treatment was 8 days.Immunofunction(IgG,IgM,IgA,C 3,C 4), serum albumin , nitrogen balance were tested.Results (1)The patients serum albumin in the study group was increased significantly as compared with control group (P