As one reform frontier to the west,with the special historical functions,the unique features of local color,Xinjiang plays a vital role in the process of the grand western region development program.We are now facing the problems of converting the leading conception of higher medical education and effectively utilizing the education resources.The objective is to provide more compound and competent medical students with creativity and practicability.

Adolescent ; Adult ; Aged ; Anti-Asthmatic Agents ; therapeutic use ; Asthma ; drug therapy ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Phytotherapy ; Prednisone ; therapeutic use ; Terfenadine ; therapeutic use

Glucocorticoids ; pharmacology ; Humans ; Medicine, Chinese Traditional ; methods ; Purpura, Thrombocytopenic, Idiopathic ; therapy

Objective To introduce an ideal method of repairing of finger volar skin defect. Methods Thirty-five patients whose finger was repaired by second digit lateral shank flap through free transplantation of lateral defect were selected. Twenty-four cases were male and 11 cases were female, with age of 21 to 45 years old. Cutting injury was in 7 cases, crush injury was in 16 cases, degloving injury was in 9 cases, and firearm injury was in 3 cases. Skin defect area was 2.0 cm × 1.5 cm-4.0 cm ×2.5 cm. The course was 1 h to 5 d. Donor area was repaired by thick skin flap. Results The postoperative wound of 35 cases all healed in stage Ⅰ, and skin flap transplantation and the donor skin grafts survived. Twenty-nine cases received follow-up for 5-26 (14.5±5.0) months. The skin flap had good appearance and good texture, with two points discrimination of 5-8 (6.7±1.1) mm. According to the Chinese medical association upper part of the function evaluation trial standard: excellent was in 19 fingers, good was in 8 fingers, and the excellent and good rate was 93.1% (27/29). Walk, run, jump functions of donor foot were normal. Conclusions Repairing finger with the second digit lateral shank flap through free transplantation of lateral defect has small area damage, and damage to the area around the organization is small. The effect of repairing is good, and can achieve the aim of the palm side repairing.

ER, PR, HER-2 are signiifcant biological markers in guiding the choice of treatment and evaluating clinical prognosis. As the progression of tumor cells, the expressions of these receptors in recurrent tumors may be different from primary tumors. Nowadays clinicians have realized the necessity of receptor detection in the metastatic lesions. This article summarized the current research status on the above issues.

Primary CNS lymphoma (PCNSL) is a rare malignancy with peculiar clinical and biologic features,aggressive course,and unsatisfactory outcome.the particular microenvironment of this malignancy,and sanctuary sites where tumor cells grow undisturbed, strongly affects treatment efficacy. The execution of prospective trials is also difficult because of the rarity of the tumor and the impaired general condition and poor performance status of patients. Chemotherapy is indispensable for the treatment of PCNSL. High-dose methotrexate is the most effctive drug.PCNSL is sensitive to irradiation,but responses to radiotherapy alone are short-lived. MTX-based chemotherapy followed by whole-brain radiotherapy prolonged survival but is associated with delayed neurotoxicity especially in patients older than 60 years. A new approach is attempted to treat PCNSL with chemotherapy alone with defered radiotherapy in old patients with similar survival rencenfly. High-dose chemotherapy with autologous stem cell transplantation HDC/ASCT yielded promising results for recurent PCNSL.Clinical investigation with Temozolomide or rituximab have been reported.Further studies with these new drugs are needed.

Objective Clinical research was made to observe the relationship between idiopathic thrombocytopenic purpura(ITP)and Helicobacter pylori(ITP)and to evaluate the effect of HP eradication in the treatment of chronic ITP.Methods ~(14)C urea breath test were made in 17 patients with chronic idiopathic thrombocytopenic purpura,including 6 males and 11 females,aging from 15-48,with course of disease from 4 months to 8 years.Omeprazole,clarithromycin and amoxicillin were used for Helicobacter pylori eradication,and the effect was evaluated by platelet count.Results Thirteen out of 17 patients were HP positive,and eleven turned negative after HP eradication,eight of whom were observed platelet recovery.Conclusion Platelet count can be raised in some patients with chronic ITP after eradication of Helicobacter pylori.

The self-learning and self-check system of medical immunology has been established by online Active Server Pages(ASP) technique.The students’learning results can be examined and evaluated automatically by the system.The students can freely choose the parameters of grouping up test-papers,according to their different situation,which is more rational and the test result is closer to students’true achievement.After the test is finished,the system can check the answers automatically and show the test-score.Through the humanized test design and the feedback encouraging teaching mode,the system affords fine conditions for independent learning of medical students and solves the problems of the combination between teachers’teaching and learners’ practicing.

Endometriosis ; etiology ; metabolism ; Environmental Pollution ; Female ; Hormones ; metabolism ; Humans ; Receptors, CCR ; metabolism

Objective: To investigate the expression of Notch1 and NF-κB in gastric cancer and discuss the association between the expressions of both and their relationship with the clinicopathological features. Methods: The expression of Notch1 and NF-κB in 168 specimens of gastric cancer and 27 specimens of normal gastric tissues were detected by SP immunohistochemistry. Results: The expression of Notch1 was significantly upregulated in gastric cancer as compared with normal gastric tissues (P < 0.0 1). It was closely related with tumor size, differentiation grade, depth of invasion, and vessel invasion. The expression of NF-κB in gastric cancer was remarkably higher than that in control group (P < 0.01) and was significantly associated with tumor size, differentiation degree, depth of invasion, distant metastasis, and vessel invasion. Kaplan-Meier analysis showed that Notch1- and NF-KB positive patients had poor prognosis than Notch1- and NF-κB-negative patients. Cox regression multivariate analysis showed that Notch1 was one of the independent prognostic factors for gastric cancer (P <0.05). Conclusion: The over-expression of NF-κB may be involved in the carcinogenesis and progression of gastric cancer mediated by Notch1 signaling pathway. Notch1 may become a potentially useful marker for evaluating the prognosis and survival of gastric cancer and a new therapeutic target.