Objective To investigate antiviral and immunoregulation effects of indole-2,3-dine(ISA).Methods The BHK-21 cell model infected with Sendai virus was established and the antiviral effect of ISA was observed by cytopathic effect(CPE) method;its effect on immunological function was observed by hemagglutination inhibition test using Sendai virus infected mice model.Results ISA showed cytotoxicity when the concentration was above(0.313)mg?mL~(-1),while ISA showed a dose-dependent antiviral effect without cytotoxicity when the concentration was among 0.156~0.039mg?mL~(-1).ISA at higher dose(2%) could accelerate the production of hemagglutination inhibition antibody in hemagglutination test(P

Objective The relationship between the clinicopathological features and the prognosis of breast cancer patients was evaluated by the expression of EPB41L4A-AS2 in breast cancer tissues.Methods The relationship between the expression of EPB41L4A-AS2 and the clinical features of breast cancer was evaluated by using the genome meta analysis,TCGA and Gene Expression Library(GEO) datasets.The correlation between EPB41L4A-AS2 and apoptotic pathway was verified by Western blotting.Results The results from Meta -analysis,TCGA and GEO datasets showed that EPB41L4A-AS2 was low in breast cancer tissues and was positively correlated with poor clinical and pathological features.EPB41L4A-AS2 was confirmed an association with the classical apoptosis pathway in breast cancer cell lines.In the meta-analysis of GEO,we found the high expression of EPB41L4A-AS2 with good prognosis.Conclusion EPB41L4A-AS2 inhibits tumor formation and has a high value in clinical prognosis of breast cancer.

Breast-Specific Gamma Imaging (BSGI) is an improved and optimizing nuclear medicine breast imaging technique on the basis of traditional gamma camera. It uses a high resolution, small field-of-view scintilla detector. The detector is designed with 3 073 individual detector crystals and 48 position-sensitive photomultiplier tubes. The FOV of detector is 15 cm x 20 cm, and optimal system resolution for breast imaging is 3 mm, can detect the diameter of only 2-3 mm small lesions. BSGI has better sensitivity in detecting subcentimetre or nonpalpable breast cancer. The sensitivity for the diagnosis of breast cancer is high, not influenced by the density of the breast tissue, implants, architectural distortion-or scars from prior surgery or radiation. So it is called a high resolution, small field-of-view breast-specific gamma camera.
Breast ; Breast Neoplasms ; diagnosis ; Diagnostic Imaging ; Female ; Gamma Cameras ; Humans

Glucocorticoids ; pharmacology ; Humans ; Medicine, Chinese Traditional ; methods ; Purpura, Thrombocytopenic, Idiopathic ; therapy

Objective: To design a convenient and safe leg support of lithotomy position surgical bed. Methods:Put the gas spring in the device to lift and drop the leg support, instead of turning screw, And then use the new leg support in 80 lithotomy position surgeries. Results:The new device can be operated by one man, it is easy operating and labor saving. There was no leg slip occurred in 80 surgeries, operators all expressed satisfaction. Conclusion: This innovation patent solved the problem of toilsome operating and potential safety hazard, It worth widely use in the clinical.

Objective To summarize the experience of diagnosis and treatment of iatrogenic injury by ureteroscopic surgery.Methods Retrospective analysis of 13 cases with iatrogenic injury by ureteroscopy from December 2008 to December 2011,including 8 men and 3 women,aged 15 to 75 years.Among the 13 cases (Holmium laser lithotripsy under ureteroscope),there were 5 cases of ureterostoma severe disruption,4 cases of submucosa injury,2 cases of perforation,1 case of disruption,and 1 case of sleeve exfoliation of mucosa.Results Among these 13 cases with iatrogenic injury by ureteroscopy,10 cases underwent double J drainage (drainage duration:60 days),and 3 cases underwent open surgery immediately.There was no hydronephrosis when examined by IVU after six months to two years follow-up.Conclusions The skills and techniques of surgical operation should be improved when performing ureteroscopic operation,and it is essential to be familiar with ureteric dissection and alignment,which can avoid ureteric injury.Indwelling D-J tube is very important in dealing with mild ureteral injury secondary to ureteroscopes.Surgical intervention should be given to severe cases of ureteric injury in time.

Obiective To realize real-time data processing in lung ventilation reconstruction based on electrical impedance tomography(EIT). Methods The image reconstruction algorithms, plotting functions and matrix calculations are dynamic transferred with Matlab C++, Mathtools and VC++ to meet the requirements of data processing and imaging in real time.Results Image reconstruction and real-time data processing were realized successfully in lung ventilation based on EIT. Conclusion It provides a new strategy for real-time data processing of image reconstruction by EIT.

Objective Cavernous hemangioma of infant was reported as an obscure diagnosis with the different sensitivity to corticosteroid therapy and various natural courses. Therefore, a clinical studies for the biological classification of deep subcutanious vascular lesions might be needed, which was alluded by Mulliken two decades ago. Methods Infants with cavernous hemangiomas accepted normal system corticosteroid therapy during the first 6 months of life before eight-year-follow-up, which continued until the children were 9 to 10 years old. The expression of PCNA and bFGF, and cellular histological characteristics were observed in 12 cases by biopsy. Results There were two major categories of subcutaneous vascular lesions groups: deep capillary hemangiomas, a lesion regressing slowly, and venous malformation, a lesion growing commensurated with the child. They will be also distinguished on the basis of diverse final treatment results, expression of cellular markers, microscopical characteristics, and physical signs. Conclusion The new classification appears to be helpful to make the choice of therapy for infants with "cavernous hemangiomas" , which is proven to be a terminologic confusion.

OBJECTIVE:To observe the clinical efficacy and ADR of Fuzheng huaji pills in the adjunctive treatment of mid-dle and advanced primary liver cancer. METHODS:122 patients with middle and advanced primary liver cancer who had lost the chance or were unwilling to accept surgery,radiotherapy or chemotherapy were randomly divided into control group (61 cases) and study group(61 cases). The control group received conservative treatment such as hepatoprotecives;the study group was treat-ed with Fuzheng huaji pills 1 pills per time,3 times a day,additionally for 30 days. The tumor volume changes,major clinical symptom scores,quality of life,hemorheology indexes and alpha-fetal protein(AFP),lab index and ADR were compared between 2 groups. RESULTS:After treatment,tumor stable rate of study group was 67.2%,the improvement rate of life quality 27.9%, and AFP(563.35±143.17)pg/L;the scores of liver pain,abdominal distension,loss of appetite and fatigue,and plasma viscosity, whole blood viscosity,erythrocyte sedimentation rate decreased greatly,there were significant differences,compared to control group (P<0.05). One patient in study group suffered from diarrhea,and the symptom was relieved after symptomatic treatment;no obvious ADR was found. CONCLUSIONS:Through stabling tumor, improving major clinical symptom, life quality and hemorheology indexes,Fuzheng huaji pills play a synergistic treatment effect on primary liver cancer.