1.Application of biochip technology and its application on medical diagnosis.
Chinese Journal of Medical Instrumentation 2013;37(5):355-357
Biochip analytical technology shows high throughput property for multi-samples measurement, so can reduce the required amount of samples and time used for determination. The technology quickly developed in recent years and has been applied in medical diagnosis and other analytical areas including gene chip, protein chip, lab-on-a-chip, tissue microarray, cell microarray, carbohydrate microarray and so on. This paper overviewed the current development of biochip technology, and explored the perspective of its application.
Diagnostic Techniques and Procedures
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Microchip Analytical Procedures
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methods
2.Situation and suggestions on IVD industrial standards.
Yan LIU ; Nan SUN ; Yumei WANG ; Shangxian GAO ; Chuntao ZHANG ; Zhaopeng YANG
Chinese Journal of Medical Instrumentation 2014;38(6):448-450
This paper briefly introduces the working procedure of in vitro diagnostic products (IVD) industrial standards, and elaborates the importance of professional standards for production and supervision. Based on the analysis of working progress during the past 10 years, some problems and countermeasures on project setting, participation, standard material, personnel training, work cycle are put forward, which are helpful for the future development of the IVD.
Diagnostic Techniques and Procedures
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standards
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Humans
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Reference Standards
3.Application of ROC and PR curves in the evaluation of clinical diagnostic testing.
Ying Xuan ZHU ; Yang LI ; Shu Tong WU ; Wei Da LIU ; Ruo Qi SONG ; Wei LI ; Yang WANG
Chinese Journal of Preventive Medicine 2022;56(9):1341-1347
This study reviewed the concepts and properties of the receiver operating characteristic (ROC) curve and precision recall (PR) curve, and made suggestions on the application of two curves based on the prevalence in combination with the results of simulation data. This study demonstrated that the ROC curve and PR curve had different properties, which could reflect the performance of diagnostic methods from various aspects. These two curves should be selected with a consideration of prevalence and clinical scenarios. When the prevalence was less than 20%, especially less than 5%, the PR curve could be adopted.
Diagnostic Techniques and Procedures
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Humans
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Prevalence
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ROC Curve
4.Evaluation of the RIPASA Score: a new appendicitis scoring system for the diagnosis of acute appendicitis
Chee Fui CHONG ; Amy Thien ; Ahamed Jiffri Ahamed MACKIE ; Aung S TIN ; Sonal TRIPATHI ; Mohammad Addy A AHMAD ; Lian Tat TAN ; Firdaus Mohamad MAT DAUD ; Caroline TAN ; Pemasiri Upali TELISINGHE ; Swee Hui ANG
Brunei International Medical Journal 2010;6(1):17-26
Introduction: We recently developed a scoring system for diagnosis of acute appendicitis. This study prospectively evaluates the Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) score for the diagnosis of acute appendicitis in patients presenting to the Accident & Emergency department or the Surgical wards with right iliac fossa pain. Materials and Methods: From November 2008 to April 2009, consecutive patients presenting to the Accident & Emergency department or the surgical wards with right iliac fossa pain were recruited for the study. The RIPASA score was applied but the decision for radiological investigations or emergency appendicectomy was made based on clinical judgement. Receiver operating curve (ROC), sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the new scoring system were derived. Ethical approval for the study was obtained from the Medical & Health Review Ethics Committee. Results: Within six months, 144 consecutive patients with a mean age of 29.5 ± 13.3 yrs were recruited to the study. Ninety-eight patients underwent emergency appendicectomy of which 79 were confirmed histologically for acute appendicitis. The observed negative appendicectomy rate was 19.4%. The optimal cut-off threshold score from the ROC was 7.5, with a sensitivity of 97.5%, specificity of 81.8%, PPV of 86.5%, NPV of 96.4% and a diagnostic accuracy of 91.8%. The predicted negative appendicectomy rate was 13.5%, which is a 5.9% reduction from the observed rate of 19.4% (p=0.3). Conclusion: The RIPASA score is a more suitable appendicitis scoring system developed for our local settings with a population that is reflective of our region in South-east Asia and has high sensitivity, specificity and diagnostic accuracy.
Appendicitis
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Appendectomy
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Diagnostic Techniques and Procedures
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Surgical Procedures, Operative
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Signs and Symptoms
5.The KAAACI Standardization Committee Report on the procedure and application of fractional exhaled nitric oxide measurement.
Jae Woo KWON ; Woo Jung SONG ; Min Hye KIM ; Kyung Hwan LIM ; Min Suk YANG ; Jae Woo JUNG ; Jeongmin LEE ; Dong In SUH ; Yoo Seob SHIN ; Sae Hoon KIM ; Sang Heon KIM ; Byung Jae LEE ; Sang Heon CHO
Allergy, Asthma & Respiratory Disease 2017;5(4):185-192
Fractional exhaled nitric oxide (FeNO) is a biomarker for type 2 inflammation in the airways, and its measurement has the distinct strengths of being simple, rapid, convenient, and reproducible. Since the discovery of FeNO in the 1990s, its measurement tools have been extensively developed and validated by several researchers. In particular, FeNO showed the potential to support the diagnosis of asthma and eosinophilic bronchitis. Since it has begun to be widely utilized in clinical research areas as well as daily practice, we summarized the standardized diagnostic procedures and suggested the clinical application of FeNO measurement in Korean population.
Asthma
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Bronchitis
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Diagnosis
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Diagnostic Techniques and Procedures
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Eosinophils
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Inflammation
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Nitric Oxide*
6.Radiographic examination protocol and patient dose in lateral cephalometric radiography in Korea.
Korean Journal of Oral and Maxillofacial Radiology 2010;40(4):165-169
PURPOSE: To survey the radiographic examination protocol for lateral cephalometric radiographic examinations and to measure their patient doses in Korea and to compare the dose according to the size of hospital, the type of image receptor system, and the installation duration. MATERIALS AND METHODS: The radiographic examination protocols (kVp, mA, and exposure time) for lateral cephalometric radiography were surveyed with 61 cephalometric radiographic equipments and their patient dose-area product (DAP) measured with a DAP meter (DIAMENTOR M4-KDK, PTW, Freiburg, Germany) for 51 cephalometric radiographic equipments. The radiographic examination protocols and patient doses were compared according to the size of hospital (university dental hospital, dental hospital, and dental clinic), the type of image receptor system (film-based, DR and CR type) and the installation duration, respectively. SPSS 12.0.1 for Windows (SPSS Inc., Chicago, USA) was used for independent t-test and ANOVA test. RESULTS: The average protocols were 77.0 kVp, 12.7 mA, 6.2 second for cephalometric radiography. The average patient dose (DAP) was 128.0 mGy cm2 and 3rd quartile dose (DAP) 161.1 mGy cm2 for cephalometric radiography for adult male. There was no statistically significant difference at average patient DAP according to the size of hospital, the type of image receptor system, and the installation duration, repectively. CONCLUSION: The average patient dose was 128.0 mGy cm2 and the third quartile patient dose 161.1 mGy cm2 for lateral cephalometric radiography for adult male in Korea.
Adult
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Chicago
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Diagnostic Techniques and Procedures
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Humans
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Korea
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Male
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Radiation Dosage
8.The proposed principles by GHTF of the classification and assessment for in vitro diagnostic (IVD) medical devices.
Shuang LI ; Bao-ai CHEN ; Zi-ming PENG
Chinese Journal of Medical Instrumentation 2009;33(6):438-440
The IVD (In Vitro Diagnostic)Medical Devices are various and develop rapidly. This paper introduces briefly the principles of classification and conformity assessment for IVD medical that proposed by GHTF (Global Harmonization Task Force).
Diagnostic Techniques and Procedures
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instrumentation
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Equipment and Supplies, Hospital
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classification
9.Neck lesions persistently seen in 131 iodine whole body scans: Are they thyroid remnants?
Gomez Jamilia L ; Goco Gerard F.L. ; Barroso Asela B
The Philippine Journal of Nuclear Medicine 2012;7(2):24-26
In not a few instances have nuclear medicine physicians encountered persistent neck lesions in 131I whole body scintigraphy despite giving repeated radioactive iodine therapy. Interpreting these lesions as still thyroid remnants served as a dilemma. This is a case of a 37-year-old female with papillary thyroid cancer. 131I whole body scans done before and one year after radioactive iodine therapy showed persistent and unchanged neck lesions. Further imaging with SPECT/CT showed laryngeal skeleton involvement. Rarity of vascular and lymphatic spread to the larynx has led to a small number of reported cases. Neck lesions should not always be immediately diagnosed as thyroid remnants.
Human
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Female
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Adult
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WHOLE BODY IMAGING
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DIAGNOSIS
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DIAGNOSTIC TECHNIQUES AND PROCEDURES
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DIAGNOSTIC IMAGING
10.Ring chromosome 10 in Filipino child: A case report and review of literature
Dion-Berboso April Grace ; Abad Lorna R. ; Esquejo Amelito L ; Chiong Mary Anne D.
Acta Medica Philippina 2011;45(4):66-69
We report a 12-day-old infant who presented with ambiguous genitalia, short stature, low-set ears, stubby nose, patent ductus arteriosus and ventricular septal defect. He was confirmed to have a ring chromosome 10 by cytogenetic analysis. Review of the literature showed that our patient shared common clinical manifestations with previously described cases.
Infant Newborn
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DISORDERS OF SEX DEVELOPMENT
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UROGENITAL ABNORMALITIES
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CYTOGENETIC ANALYSIS
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DIAGNOSIS
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DIAGNOSTIC TECHNIQUES AND PROCEDURES
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CLINICAL LABORATORY TECHNIQUES
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CYTOLOGICAL TECHNIQUES