Dapiprazole produces miosis by blocking the alpha 1 receptors in the dilator muscle of the iris.Intraocular dapiprazole for reversing mydriasis has been compared with intraocular carbachol.Ten adult rabbits of same breed, weight, and age group were used.Both pupils were dilated with one drop each of 2.5% phenylephrine and 0.5% tropicamide.After 10 minutes, when full mydriasis was present, 0.2 ml of aqueous humor was removed from the anterior chamber of each eye through a limbal puncture and replaced with equal amount of 0.5% dapiprazole solution on one eye, and with 0.01% carbachol on the other eye.Pupillary diameter recordings were performed immediately before and a few minutes after drug injection, as well as 24 hours after limbal puncture.Intraocular pressure, corneal thickness, corneal endothelial cell count, and protein in the aqueous humor were evaluated prior to surgery and one day postoperatively.The results showed no difference in the miotic efficacy of dapiprazole and carbachol.The level of aqueous humor protein was significantly higher in the carbachol-treated eyes than in the dapiprazole-treated eyes.No significant difference in intraocular pressure, corneal thickness, and corneal endothelial cell density was noted.Intraocular 0.5% daapiprazole is comparable to 0.1% carbachol in efficacy and safety with less effect on the blood-aqueous barrier.
Animal ; CARBACHOL ; CATARACT ; DAPIPRAZOLE