1.Preliminary study on association of β2 - Adrenergic Receptor Polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
AE Atia ; K Norsidah ; A Nor Zamzila ; M Rafidah Hanim ; D Samsul ; MAM Aznan ; AR Rashidah ; AT Norlelawati
The Medical Journal of Malaysia 2012;67(1):25-30
Polymorphisms within the β2-adrenergic receptor (ADRB2)
gene have been repeatedly linked to hypertension. Among
the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu
codons are considered the two most important variations.
The amino acid substitution at these codons may lead to
abnormal regulation of ADRB2 activity. The aim of the
present study was to assess the association between ADRB2
polymorphisms and hypertension. This case-control study
consisted of 100 unrelated subjects (50 hypertensive and 50
matched normal controls). Arg16Gly and the Gln27Glu
polymorphisms were analyzed by polymerase chain reactionrestriction
fragment length polymorphism assay. There were
no significant evidence of association in allelic and
genotypes distribution of Arg16Gly and Glu27Gln with
blood pressure and hypertension. These findings suggest
that the variation within codon 16 and 27 of ADRB2 gene
were unlikely to confer genetic susceptibility for
hypertension in our population samples.
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