1.Effect of Anti-inflammatory Drug on the Cyclooxygenase-2 Protein Expression in Lipopolysaccharide-Stimulated Amnion Cells in Culture.
Pil Ryang LEE ; Bok Kyung JUNG ; So Ra KIM ; Ji Ahn KANG ; Myung Shin SHIN ; Hye Sung WON ; In Sik LEE ; Ahn KIM
Korean Journal of Perinatology 2000;11(4):490-497
No abstract available.
Amnion*
;
Cyclooxygenase 2*
2.Cyclooxygenase-2: A Potential Target in Human Cancer.
Cancer Research and Treatment 2004;36(3):161-162
No abstract available.
Cyclooxygenase 2*
;
Humans*
3.Expression of Cyclooxygenase-1 and -2 in Synovial Tissues from Patients with Rheumatoid Arthritis.
Young Ho LEE ; Seong Jae CHOI ; Jong Dae JI ; Aeree KIM ; Chul Hwan KIM ; Gwan Gyu SONG
The Journal of the Korean Rheumatism Association 1998;5(2):159-168
No abstract available.
Arthritis, Rheumatoid*
;
Cyclooxygenase 1*
;
Cyclooxygenase 2
;
Humans
;
Osteoarthritis
4.Cyclooxygenase-2 Expression in Ovarian Tumors.
Woo Seok SOHN ; Bong Sik MIN ; Chang Mo KIM ; Sung Joo KIM ; Jung Bae KANG ; Hye Rim PARK ; Pong Rheem JANG
Korean Journal of Obstetrics and Gynecology 2001;44(7):1237-1241
OBJECTIVE: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumorigenesis of gastrointestinal and other cancers. This was the study to determine whether COX-2 was also expressed in benign and malignant ovarian tumors. METHODS: We studied the expression of COX-2 in various ovarian tumors [ Benign epithelial tumors (n=10), borderline epithelial tumors (n=12), malignant epithelial tumor (n=12), nonepithelial tumors(n=10) ] by immunohistochemistry. Results of immunoreactivity was classified semiquantitatively based on the proportion and intensity of tumor cell immunostaining. RESULTS: In the epithelial ovarian tumors, the intensity of immunostaining was stronger in the malignant tumors than the benign and borderline tumors (p<0.001). Especially all serous and mucinous malignant tumors (n=9) showed weak and strong immunoreactivity, with 66.7% strong reactivity. None of the nonepithelial ovarian tumors expressed COX-2 immunoreactivity. CONCLUSION: These preliminary data indicate that COX-2 may have a role in carcinogenesis of epithelial ovarian tumors, especially in the serous and mucinous types. COX-2 maybe a target for future research in the tumorigenesis of the epithelial ovarian malignancies.
Carcinogenesis
;
Carcinoma
;
Cyclooxygenase 2*
;
Immunohistochemistry
;
Mucins
5.Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm.
Wan Mohd Nuzul Hakimi Wan SALLEH ; Farediah AHMAD ; Khong Heng YEN ; Razauden Mohamed ZULKIFLI
Natural Product Sciences 2016;22(4):225-230
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 – 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 – 504.2 µM and 21.0 – 59.4 µM, respectively.
Acetylcholine
;
Cyclooxygenase 2
;
Inhibitory Concentration 50
;
Lignans
6.Involvement of Mitogen-Activated Protein Kinase in Aspirin-induced Expression of Cyclooxygenase-2 in Amnionic Cell Line WISH Cells.
Goo Hwa JE ; Moon Suk CHA ; Jong Young GWAK
Korean Journal of Obstetrics and Gynecology 2000;43(12):2191-2197
No abstract available.
Amnion*
;
Cell Line*
;
Cyclooxygenase 2*
;
Protein Kinases*
8.Cyclooxygenase-2 Expression Predicts Prognosis in Astrocytic Tumors.
Jong Myong LEE ; Shin JUNG ; Hyang Hwa RHU ; In Young KIM ; Min Cheol LEE
Journal of Korean Neurosurgical Society 2004;36(6):437-442
OBJECTIVE: Cyclooxygenase-2, the inducible isoform of prostaglandin H synthesis, has been implicated in the growth and progression of a various human cancer. Although COX-2 overexpression has been observed in humangliomas, the prognostic or clinical relevance of this overexpression has rarely been investigated to date. METHODS: We examined COX-2 expression by immunohistochemistry in tumor specimens from 25 patients with low- and high grade astrocytomas and correlated the grade of COX-2 expression with patients survival. RESULTS: Immunohistochemical staining results were as follows: negative staining, N=4(16%), positive staining, N=21(84%). Results of low grade astrocytoma(N=10) were as follows: negative staining, N=3(30%), weak positivestaining, N=7(70%). Anaplastic astrocytomas(N=4) as follows: negative staining, N=1(25%), weak positivestaining, N=3(75%). Glioblastomas(N=11) as follows: negative staining, N=0(0%), weak positive staining, N=5(45%), strong positive staining, N=6(55%). As a group, tumors with higher rate of cell proliferation tended to have increased expression of COX-2. The percentage of COX-2 expression were associated with a worse survival rate(p=0.0028), and the grade of astrocytic tumors(p=0.001). These findings indicate that high COX-2 expression in tumor cell is associated with clinically more aggressive gliomas, and is a strong predictor of poor survival. CONCLUSION: Our study provides evidence that COX-2 is up-regulated in the majority of high-grade gliomas and that increased COX-2 expression is a significant negative predictor of survival and selective COX-2 inhibitors may have a potential role as an adjuvant therapy of astrocytic tumors.
Astrocytoma
;
Cell Proliferation
;
Cyclooxygenase 2 Inhibitors
;
Cyclooxygenase 2*
;
Glioma
;
Humans
;
Immunohistochemistry
;
Negative Staining
;
Prognosis*
9.Cyclooxygenase-2 Expression in Periampullary Cancer.
Young Jin CHOI ; Guang Bi JIN ; Lee Chan JANG ; Jin Woo PARK ; Rohyun SUNG ; Jae Woon CHOI
Journal of the Korean Surgical Society 2003;65(1):49-54
PURPOSE: Cyclooxygenase-2 (COX-2) expression is up-regulated in several types of human cancers and it has been suggested that COX-2 is closely inked to carcinogenesis. The objectives of this study were to investigate COX-2 expression in periampullary cancer and to evaluate the association of the clinicopathological factors with its expression. METHODS: Thirty specimens which were resected from patients with periampullary cancers (13 pancreatic adenocarcinomas, 8 common bile duct cancers, 9 ampulla of vater cancers) were investigated by immunohistochemical staining using Anti COX-2 monoclonal Ab. The 30 specimens were divided into stain-positive and stain-negative groups. The correlation between COX-2 expression and the various clinicopathological factors including the tumor size, nodal metastasis, differentiation, perineural and vascular invasion, were studied. RESULTS: COX-2 was expressed in 69% of pancreatic adenocarcinomas, 100% of common bile duct cancers and 78% of ampulla of vater cancers. However there was no significant correlation between COX-2 expression and the clinicopathological factors. CONCLUSION: COX-2 is highly expressed in periampullary cancer. Even though there was no correlation with the clinicopathological factors, the utility of the COX-2 inhibitors in preventing or treating periampullary cancer remains undetermined but warronts further investigation.
Adenocarcinoma
;
Ampulla of Vater
;
Carcinogenesis
;
Common Bile Duct
;
Cyclooxygenase 2 Inhibitors
;
Cyclooxygenase 2*
;
Humans
;
Ink
;
Neoplasm Metastasis
10.Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer.
Song XU ; Jian-Ping GAO ; Wen-Quan ZHOU
National Journal of Andrology 2008;14(11):1031-1034
Cyclooxygenase-2 (Cox-2) is over-expressed in prostate cancer (PCa) and involved in its development and progression by facilitating inflammatory response, reducing cell apoptosis, increasing angiogenesis and damaging DNA oxidation. Selective Cox-2 inhibitors suppress PCa growth through various channels and therefore have a promising application value in the management of prostate cancer.
Apoptosis
;
Cyclooxygenase 2
;
metabolism
;
Cyclooxygenase 2 Inhibitors
;
therapeutic use
;
Humans
;
Male
;
Prostatic Neoplasms
;
drug therapy
;
metabolism