Objective To investigate the relationship between concentration of plasma homocysteine(Hcy) and recurrence of ischemical cerebral stroke(ICS).Methods Plasma Hcy concentration were measured using fluorescence polarization immunoassay(FPLA) in 303 primary and 97 recurrent ICS patients [173 cases of atherosclerotic thrombotic cerebral infarction(thrombotic group),170 cases of lacunar cerebral infarction(lacunar group) and 57 cases of cardiogenic embolism] and 200 non-cerebrovascular disease patients(control group).Multifactorial regression analysis was conducted on recurrent factors contributing to ICS.Results(1) Plasma Hcy concentration in patients with ICS [thrombotic group(16.17?10.83) ?mol/L,lacunar group(14.64?7.71) ?mol/L,cardiogenic embolism group(15.75?6.8) ?mol/L] were significantly higher than that in the control group [(9.61?4.22) ?mol/L](all P