Objective To determine the clinical value of an incision made at the areola mammae and pressure closure of residual cavity technology applied to remove benign breast lumps .Methods 2 264 patients from January 2006 to May 2012 were performed using an incision made at the areola mammae for removing benign breast lumps and a pressure bandage to close the residual cavity in our department .The therapeutic results were evaluated through follow-up .Results All the benign breast lumps were resected safely and completely .The diameter of the single lump was 0 .5-8 .0 cm and the number of lesions was 1-42 .The mean operative time was 37 min(5-162 min) .There was minimum scar formation on breast ,the outline of the breast was maintained ,the rate of generating gelosis was 25 .4% ,the mean time of developing gelosis was 29 days(18 -40 days) ,and the rate of satisfaction was 98 .4% .No sever complications were found .Conclusion The technique in which an incision made at the areola mammae and pres-sure closure of residual cavity technology was applied to remove benign breast lumps is single ,safe and feasible surgical procedure with cosmetic results in clinical application .

Objective To explore the effect of Ligustrazine on neurogenesis in cortex after focal cerebral ischemia in rats. Methods Focal cerebral ischemia was induced by left middle cerebral arteryocclusion with asuture. Two hours later, injection of Ligustrazine (80 mg/kg, 1 time/d) was performed peritoneally. Four hours after the ischemia,5-bromodeoxyuridine (BrdU) (50 mg/kg, 1 time/d) was injected peritoneally. At 7 d, 14 d and 21 d after ischemia,BrdU positive cells in the cortex were observed by immunohistochemical staining. Results In ischemic model group, at 7 day, sparsely-distributed BrdU positive cells were observed in the Ⅱ - Ⅵ layers of the ipsilateral cortex, with a band-like distribution in ischemic penumbra. With the prolongation of ischemia, the number of BrdU positive cells increased.In Ligustrazine group, BrdU positive cells were also observed in the Ⅱ - Ⅵ layers of the cortex, with an intense distribution in ischemic penumbra. The numbers of BrdU positive cells at 7 d, 14 d and 21 d were more than those in ischemic model group respectively. Conclusion Ligustrazine increases the proliferated cells in cortex after focal cerebral ischemia in rats. The results suggest that it may be useful for promoting self-repair after ischemia.