The article describes immune disorder mechanisms of allergic rhinitis and the progress and clinical application status of the nonspecific immune therapy of allergic rhinitis, which can raise people's understanding about the nonspecific immune therapy of this disease.
Humans ; Immunotherapy ; methods ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; therapy

General education is the quality education of higher education , which includes the humanities , so-cial science and natural science .It point out the present status of medical colleges and universities to carry out the general education of humanities and the existing problems which based on the current China 's higher medical colle-ges and universities to strengthen the urgency of the general education of humanities .It main including:the lack of humanistic concept of general education and human general curriculum is not reasonable ;the human general educa-tion hasn't dived into the medical professional education which lead to the students attention degree is not enough ;Human general education methods is single , practical link is weak .To solve these problems should be set up a med-ical humanities general education organization and management agencies , build reasonable medical humanities gen-eral course system , strengthen the construction of teaching staff of a curriculum , improve education curriculum teaching methods and many other countermeasures and suggestions .

Cyclin E is expressed starting from the middle G1 phase of the cell cycle,and is accumulated in the G1/S boundry.Cyclin E binds to and activates the cyclin-dependent kinase CDK2.Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates,such as Rb,CDC6,NPAT and P107,etc.Additionally,cyclin E plays an important role in the regulation of genomic stability,spindle-organizing structure and centrosome cycle.Cyclin E expression is trans-activated by members of the transcription factor E2F family and degrades via the ubiquitin-proteasome pathway.At the same time,it is also negatively regulated by the CIP/KIP proteins.Cyclin E highly expressed in the initiation and progression of different human cancers,such as breast cancers,lung cancers,leukemia,lymphomas and others.

Objective To analyze the relationship between the serum CysC,lipoprotein(a) [Lp(a)] and the urinary microalbumin/creatinine ratio in elderly type 2 dibetic (T2CM) patients.Methods A total of 102 elderly patients with T2CM who were treated in our hospital from December 2014 to December 2015 were selected.The patients were divided into diabetic nephropathy(DN) group(mALB≥20 μg/min,48 cases)and non-diabetic nephropathy(NDN) group (mALB<20 μg/min,54 cases) according the levels of urinary mALB,while 30 cases of healthy controls were selected from physical examination center.The biochemical indexes,CysC,Lp(a) and UACR were detected among all cases.The correlation between indexes and UACR was analyzed by Pearson correlation analysis,risk factors for UACR among DN patients were analyzed by Logistic regression analysis.Results There were significant differences in levels of low density lipoprotein cholesterol(LDL-C),Lp(a),urea,creatinine,fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),Cysc,and UACR among these groups (P<0.05).No correlation between CysC、Lp(a) and UACR was found in normal-control group and non-diabetic nephropathy group.In diabetic nephropathy group,there was a positive correlation between CysC,Lp(a) and UACR(r=0.658,P<0.01;r=0.525,P<0.05).The Logistic regression analysis showed that diabetes duration,CysC,Lp(a) were independent risk factors for UACR(P<0.05).Conclusion In patients with diabetic nephropathy,CysC,Lp(a) are positively correlated with UACR,and CysC is a sensitive index that reflect early renal damage in T2DM patients.Lp(a) level is one of the independent risk factors for UACR,which can reveal the kidney damage in DN patients.

OBJECTIVE: To evaluate the effect and feasibility of coblation treatment for laryngopharynx hemangioma. METHOD: Retrospectively analyzed 24 cases with coblation treatment for laryngopharynx hemangioma in recent years. RESULT: Twenty-four patients were treated with coblation, follow-ups range 6 months to 24 months after surgry. Recurrence occurred in 2 months after surgry in one patient who was cured with coblation for second time. There was incomplete vocal cord paralysis in another patient because of wide range angeioma. CONCLUSION Coblation treatment for laryngopharynx hemangioma was an ideal way to less bleeding, less damage and more clearfield of vision.
Catheter Ablation ; Hemangioma ; surgery ; Humans ; Hypopharynx ; pathology ; surgery ; Laryngeal Neoplasms ; surgery ; Neoplasm Recurrence, Local ; Pharyngeal Neoplasms ; surgery ; Retrospective Studies ; Vocal Cord Paralysis

Objective To explore the tabular condition assessment methods in the role of early warning of children with severe hand, foot and mouth disease. Methods A total of 267 patients in observation group were evaluated by the disease assessment scale of hospitalized children with hand, foot and mouth disease and the risk assessment form of severe children with hand, foot and mouth disease to early indentify the severe and give intervention treatment. And the 243 patients in control group were evaluated by the empirical method. The incidence of severe cases and the incidence of complications were compared between two groups. Results The incidence of severe cases was 3.00%(8/267) in observation group and 17.70%(43/243) in control group, and there was significant difference between two groups, χ2=30.970,P<0.01. The incidence of total complications was 9.74%(26/267) in observation group and 32.51%(79/243) in control group, and there was significant difference between two groups, χ2=34.74,P<0.01. Conclusions The tabular condition evaluation method can early identify the children with severe hand, foot and mouth disease and give early intervention, reduce the incidence of severe and critical cases, and reduce the complications.

Objective To observe the therapeutic effect of ear-acupuncture therapy for intractable hiccups in the patients treated with endovascular embolization for bleeding from spontaneous rupture of liver cancer. Methods A total of 60 patients with intractable hiccups after endovascular embolization for bleeding from spontaneous rupture of liver cancer were randomly divided two groups using a random digit table, 30 in each group. The patients in the control group were treated breath holding combined with oral baclofen, and those in the observation group with ear-acupuncture therapy for 5 days, and then both groups were followed up for 1 week. The Karnofsky Performance Status Scale (KPS) was used for quality of life evaluation. The adverse events and recurrence during the treatment and the followed up were recorded. The therapeutic effect was evaluated. Results Total effective rate (100% vs. 76.7%; χ2=5.822, P=0.016)in the observation group was significantly higher than that in the control group. The rate of adverse events (6.7% vs. 33.3%; χ2=5.104, P=0.024)in the observation group were significantly lower than that in the control group. There was no significant difference in the KPS scores after treatment between the observation group and the control group (82.1 ± 12.6 vs. 76.5 ± 17.8; t=1.407, P=0.165). Conclusions Ear-acupuncture therapy may efficiently alleviate intractable hiccups in patients treated with endovascular embolization for bleeding from spontaneous rupture of liver cancer, and superior to breath holding combined with oral baclofen.

A 56 years old female was admitted to our department with complaint of a painless cervical mass. Clinical feature:there was a painless mass above left lobe of thyroid gland, which was about 3.0 cm x 2.5 cm in size, and could move with swallowing action. B-mode ultrasound features: there was a solid mass in left lobe of thyroid gland, which was about 3.2 cm. Nodule was found in isthmus, accompanied with lymphadenovarix on the left neck possibly be MCA. fT3: 4.64 pmol/L, fT4:16.56 pmol/L,TSH:3.74 mIU/L, anti-TG:17.75 U/ml, anti-TPO:40.77 U/ml. Pathological result of the neoplasm: papillocarcinoma. Clinical diagnosis: papillary thyroid carcinoma.
Carcinoma ; diagnosis ; pathology ; Carcinoma, Papillary ; diagnosis ; pathology ; Deglutition ; Female ; Humans ; Middle Aged ; Neck ; pathology ; Parathyroid Glands ; pathology ; Recurrent Laryngeal Nerve ; pathology ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; diagnosis ; pathology

The patient was a 42 years old female. And the reason why she was addmited to the hospital was progressive bilateral nasal congestion for one year, and bilateral nasal bleeding for one day. Physical examination showed no surgical contraindication so the patient got the nasal endoscope by plasma radiofrequency ablation surgery with general anesthesia on 3rd Dec. 2013. And the result of potholegical examination was nasopharynx pleomorphic adenoma.
Adenoma, Pleomorphic ; pathology ; surgery ; Adult ; Catheter Ablation ; Endoscopy ; Epistaxis ; Female ; Humans ; Nasal Cavity ; pathology ; Nasopharyngeal Neoplasms ; pathology ; surgery

A 6 years old boy came to our department with a complaint of a growing goitre behind and below the right ear that started 4 years ago. Clinical features: there was a 2.0 cm x 1.5 cm nontender goitre behind and below the right ear, protruding from the skin with clear boundary. The temperature and color of the skin covered the goitre were normal. B-mode ultrasound features: there was a mass under the skin with the size of 2.0 cm x 0.8 cm showing strong echo. The borders of the mass were unclear, and no signal of blood flow was detected. Pathology diagnosis: pilomatricoma.
Child ; Face ; Goiter ; Hair Diseases ; diagnosis ; pathology ; Humans ; Male ; Pilomatrixoma ; diagnosis ; pathology ; Skin ; Skin Neoplasms ; diagnosis ; pathology