Objective To investigate the status quo of social support and effective disorder nurses perceived in the operating room and analyze the correlation between them. Methods A total of 200 nurses in the operating room of four general hospitals in Guangxi Zhuang Autonomous Region were enrolled to investigate the social support and the effective disorders using the perceived social support scale (PSSS) and Toronto Alexithymia Scale (TAS). Results The total scores by PSSS and TAS were (66.08 ± 10.64) and ( 53 . 85 ± 8 . 89 ) , respectively . The scores by PSSS and its dimensions were all negatively correlated with the score by TAS ( r=-0 . 492 , P < 0 . 05 ) . Conclusions The nurse-perceived social support is generally at the medium or above level and their affective disorder at a lower level. The nursing managers should pay attention to the nurses in the operating room, taking corresponding measures to improve their affective disorder and improve the quality of nursing.