Objective To investigate the curative effect of pidotimod combined with Yanhuning for children with refractory mycoplasma pneumoniae pneumonia(RMPP).Methods 150 patients with RMPP in our hospital were divided into 3 groups,including Yanhuning group(A group),azithromycin combined with Yanhuning group(B group) and pidotimod combined with Yanhuning group(C group).And the total effective rate,the clinical symptoms,immune function parameters were analyzed.Results Compared to A group,the effective rate of B group and C group were sig-nificantly higher(all P <0.05),but there was no statistically significant difference between B group and C group. Compared to A group,the defervescence time,cough disappeared time and rales disappeared time were significantly shorter(all P <0.05),and the effect in C group was better than that in B group (all P <0.05).Compared to normal control group,CD +3 ,CD +4 ,CD +4 /CD +8 and CD +16 CD +56 in A group,B group and C group before the treatment were sig-nificantly lower(P <0.05),but IgG,IgM,CD +8 and CD +19 were significantly higher(all P <0.05).And CD +3 ,CD +4 , CD +4 /CD +8 and CD +16C D +56 in C group were significantly higher(all P <0.05)after the treatment.During follow -up, compared to A group,the recurrence rate and time in B group and C group were significant reduction(all P <0.05), and the recurrence rate and time in C group were less than that in B group (all P <0.05).So the regulation of immune function in C group was more significant than that in A group and B group,the prognosis was better,and the repeated times and continuous time were decreased.Conclusion Pidotimod combined with Yanhuning treatment of RMPP can regulate the immune function of children,improve clinical symptoms,which should be promoted.

Complement receptor of the immunoglobulin superfamily ( CRIg) can regulate immune reactions via T cells and cy-tokines and is involved in various diseases .The effect of CRIg on the pathogenesis of immunological liver injury , intestinal ischemia-reperfusion injury , type Ⅰdiabetes mellitus , experimental autoimmune uveoretinitis , and rheumatoid arthritis etc .in animal models of disease are reviewed in this article .

Objective To explore and provide guidelines for the clinical diagnosis and treatment of primary nephrotic syndrome complicated with acute pancreatitis. Methods The clinical data of 14 children with primary nephrotic syndrome complicated with acute pancreatitis during September 2013 to September 2016 were retrospectively analyzed. Results In 14 children (6 males and 8 females) aged 3 to 15 years. all children presented massive proteinuria, hypoalbuminemia, varying degrees of edema, hyperlipidemia and pain in upper abdomen or left hypochondrium. Seven children had nausea and vomiting, and their amylase in serum and urine fluctuated at 392–802 U/L and 561–3180 U/L, and the lipase level was 339.1±2.52 U/L. After supportive treatment, 13 children were cured from pancreatitis except one who gave up the treatment. Conclusion Due to infection, coagulation disorder, hyperlipidemia and drug application in primary nephrotic syndrome, acute pancreatitis may be induced. Clinician should be alerted to it and early diagnosis and treatment were needed for acute pancreatitis.

Objective To survey the 238U radioactivity level in the surface soil in the Beijing-Tianjin-Hebei Border (BTHB) region,and to prepare a high resolution distribution map of 238U activity concentrations.Methods The soil samples were collected in a grid (10 km × 10 km).The activity concentrations of 238U in soil samples were measured by using HPGe γ spectrometry.The distribution of the activity concentrations of 238U in soil samples was mapped by the aid of MAPGIS software.Results In total,416 samples were collected and measured.The activity concentrations of 238U were in the range of 0.1-106.0 Bq/kg,with an average of 34.7 Bq/kg.The 238U activity concentration distribution map showed that 238U activity concentration was in the range of 15-55 Bq/kg mostly on the surface soil in the BTHB region.Conclusions The map of 238U activity concentration shows the distribution of 238U activity concentration in the BTHB region.It is of importance to map the distribution of 238U activity concentration in the BTHB region,by converting a huge amount of data into the simple and intuitive graphics,and for evaluating the regional environmental radioactivity and studying the radioactive substance migration within the locality.

Objective To organize measurement comparison among provincial CDC gamma spectrometry laboratory for verification of the precision and accuracy of the measuring results from each laboratory and to improve the ability and level for radionuclides measurement in building materials.Methods The method for gamma spectrometry measurement comparison was referred to the method of IAEA international comparison in 2002.Results The results of these labs in this comparison agreed with the reference results well.About 50% labs' relative biases were less than 5%,over 80% labs were less than 10%.Conclusions The results of this comparison showed that the analysis method for the radioactivity content in building materials by gamma spectrometry in each lab was credible and meet the request of the standard GB 6566-2001 "Radioactive Nuclide Limit for Building Materials".

Objective To assess the accuracy and precision of γ-spectrometry analysis, and to obtain accurate and valid measurement results in the middle term and long term. Methods A nationwide intercomparison on gamma-ray spectrometry measurement of activity concentration of 226Ra, 232Th and 40K in soil and building material was organized by National Institute for Radiological Protection( NIRP) , China CDC. Results 15 laboratories participated in this intercomparison, with 13 laboratories produced acceptable results. Only 2 laboratories were classified as " not acceptable" , including one for inappropriate accuracy in determination of 40K and another for inappropriate precision determination of 226Ra in both kinds of the samples. Through comment and discussion, the second round intercomparison got satisfactory results. Conclusions The overall measurement results of samples for intercomparison are in close agreement with the reference values. Most of the laboratories involved in the intercomparison have good ability in γ-spectrometry analysis.

Objective To describe a simplified generic procedure to evaluate the external exposure dose evaluation in radiological emergency, and to compile the corresponding computer software. Methods Based on the related reports of IAEA, this generic procedure of external exposure dose evaluation in radiological emergency was compiled to computer software by Visual Basic 6.0. Results The generic procedure for evaluation of external exposure dose could be used in the external exposure radiation accident emergency. The actual accident data were input in this software, then the results from this software agreed with those of the actual accident well. The maximum error was 40% , and the minimum error was 6%.Conclusions The generic procedure for evaluation of external exposure dose could provide practical emergency response guidance. The software might help to evaluate the accidental dose more quickly and accurately, and provide scientific basis to take the immediate response actions.

ObjectiveTo study the correlations between Berg balance scale (BBS) and balance subscale of Fugl-Meyer test (FM-B), and evaluate their practicability for assessing balance function of patients after stroke.Methods68 stroke inpatients were assessed with BBS, FM-B and BPM before training. After training they were re-assessed by the same researcher. The parameters of BPM were sway index, sway tract length and area. The patients were assessed twice with eye opened and eye closed respectively.ResultsThere was no significant difference in the score of FM-B between the first assessment and after training (P>0.05), while that of BBS and BPM after training were better than before the training (P<0.001). There was moderate correlation between FM-B and BBS (r=0.517,P<0.001), but there was no correlation between FM-B and BPM (r=-0.074～-0.247,P>0.05). There was moderate negative correlation between BMP and BBS (r=-0.410～-0.587,P<0.01).ConclusionBBS and BPM are good tools for assessing balance function of stroke patients; FM-B shows low sensitivity and is not suitable for assessing stroke patients.

Insulin-like growth factorⅠ(IGF-Ⅰ) is essential for the growth and differentiation of hair follicles which is an important part of wool and cashmere.But there is no report on polymorphisms of the IGF-Ⅰ gene in cashmere goat,and also few candidate genes for cashmere production traits have been reported in cashmere goats.The objectives of this work were to detect the single nucleotide polymorphism(SNP) in the 5' flanking region of IGF-Ⅰ gene and to determine their association with fibre traits in Liaoning cashmere goats.The fibre traits data investigated in the experiment were combed cashmere weight,cashmere fibre length and cashmere fibre diameter.A few individuals of the Liaoning cashmere goats,selected according to phenotypic character,were used for SNPs detection in the 5'flanking region of IGF-Ⅰ gene,and four point mutation G→C(388 bp),A→G(668 bp),A→ C(719 bp),G→A(752 bp) were identified,which result in a CdxA bonding-site lack,and score increase of C/EBP site in the 5' flanking region compared with the wild type.Then different genotypes were detected in 520 Liaoning cashmere goats using create restriction site(CRS) and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),three genotypes,AA,AB and BB were observed coded for by two different alleles A and B for each SNP,and 13 diplotypes were identified in the groups of the four SNPs.The relationships between the genotypes and combed cashmere weight,cashmere fibre length and cashmere fibre diameter were analyzed.The statistical analysis showed that animals with the genotype AA of SNP2 in Liaoning cashmere goats had the thinnest cashmere fiber diameter compared with those with the AB and BB genotype(P

OBJECTIVE To investigate the relationship of nosocomial infection with use of antimicrobial agents.METHODS A retrospective study of 171 cases admitted from Nov 2004 to Apr 2005 in a general hospital.RESULTS Sixteen thrush cases all were found to have prior use of antimicrobial agents with average time about(12.5?8.10) days.Twenty six out of 57 surgical cases had wound infection,all used antimicrobial agents preoperatively.Inadequate use of antimicrobial agents manifested as prolonged use or over frequent drug change or improper combined use of drugs etc.CONCLUSIONS Protracted use of antimicrobial agents may be related with development of thrush.Rational use of antimicrobial agents is to be emphysized.