Child ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Eye Diseases ; drug therapy ; therapy ; Female ; Humans ; Middle Aged

To explore the origin and prevention of myopia from disfunction of internal organs and obsrtuction of channels.According to the research of ancient literature on relationship between internal organs/channels and myopia,and in the combination with research on neuroelectrophysiology,hemorheology molecular biology and clinic study,the feasibility of treatment on myopia from dysfunction of internal organs and obstruction of channels were analyzed.Dysfunction of internal organs and obstruction of channels played an increasingly important role in the occurring and developing of myopia.In the treatment of myopia,the role of internal organs and channels must be emphasized.

Objective To get overview about diarrhea condition of HIV/AIDS cases among paid blood donors in our country. Methods One-to-one questionnaire was adopted to investigate a total of 285 HIV/AIDS cases among paid blood donors in Henan province. Diarrhea HIV/AIDS patients were further picked out according to 'Criteria of HIV/AIDS diarrhea'and their syndrome characteristics were analyzed. Results There was 41 diarrhea HIV/AIDS patients in all 285 HIV/AIDS cases (14.39%). Deficiency Syndrome and mixed insufficiency and excess syndrome were predominant Syndromes in these patients. Conclusion The rate of diarrhea in HIV/AIDS cases among paid blood donors of our country was lower than some foreign countries. Such internal organs as spleen, liver, kidney, stomach and lung were mainly involved in the disease.

Objective To get an overview to studies of traditional Chinese medicine treating HIV-related diarrhea recently, and analysis the predominance and inadequacies of these studies. Methods Articles about TCM treating HIV-related diarrhea from 1981 to 2008 in CNKI, CBM, VIP and MEDLINE were summarized and analyzed by analyzing and found, showing the shortages in the methods, detections, and evaluation of treating this disease.

Objective To study the expression of cyclooxypenase-2(COX-2),prognosis of patients and the correlation between COX-2 and CD_(105)in osteosarcoma.Methods The expression of COX-2 and CD_(105)in human osteosarcoma was detected with immunohistochemistry.Then to count the microvessl density (MVD)were marked with CD_(105),The prognosis of the patients with osteosarcoma was analyzed by Cox multi- variate survival analysis.Results The positive rate of COX-2 expression was 77.5 %,The expression of COX-2 was positively correlated with surgical grade and metastasis of osteosarcoma;There were significant difference between surgical grade Ⅰ and Ⅱ b、grade Ⅰ and Ⅲ(P0.05);Metastatic cases had higher MVD than those without metastasis(P

Objective: To systematically review the association between apolipoprotein E (APOE) gene polymorphism and cerebral infarction in Chinese Han population. Methods: The pertinent literature of the gene polymorphism and the case control studies of cerebral infarction in Chinese Han population were researched comprehensively by combined application of 5 effective retrieval approaches. The odds ratio (OR) of the genotype distribution in cerebral infarction group and control group were calculated. Results: A total of 1986 patients with cerebral infarction and controls were included in the meta-analysis. After the data were pooled, the OR values of ApoE ε2/ε3, ApoE ε3/ε3, ApoE ε2/ε4, ApoE ε3/ε4, and ApoE ε4/ε4 were 0. 59 (95% CI, 0.44-0. 79), 0. 52 (95% CI, 0. 40-0.69), 2.00 (95% CI, 1.22-3.28), 2.77 (95% CI, 1.60-4.81 ), and 4. 66 (95% CI, 1.61-13.48), respectively. Conclusions: ApoE ε2/ε4, ApoE ε3/ε4 and ApoE ε4/ε4 genotypes are the risk factors of cerebral infarction. ApoE ε2/ε3 and ApoE ε3/ε3 genotypes are the protective factors of cerebral infarction.

To investigate the risk factors for intracerebral hemorrhage in general population.Methods:The related research was searched through English Medical Current Contents (EMCC),China Hospital Knowledge Database (CHKD),MEDLINE,and Chinese Biomedical Literature Database (CBM).The search terms were intracerebral hemorrhage,factor,and case-control study or cohort study.Results:There were 8 literatures with original data were in accordance with the inclusion criteria.All the data could not be combined because there were some differences in counting and metrology in the risk factors included in all the studies.Hypertension,family history of cerebrovascular disease,high salt diet,alcohol consumption,diabetes mellitus,high diastolic pressure,high systolic pressure,smoking,snoring disease,and increased weighted mean difference of body mass index (BMI) (95% confidence interval) were 5.71 (4.00-6.79),3.54 (2.44-5.14),2.58 (1.94-3.43),2.80 (2.29-3.43),2.78 (1.83-4.23,1.90 (1.35-2.70),17.76 (16.60-18.92),30.43 (28.61-32.25),5.42 (5.15-5.70),1.90 (1.34-2.69),6.88 (4.61-10.26,and 5.42 (5.15-5.70),respectively.There were significant differences between the patient groups and control groups among the above indexes (all P<0.000 01).Conclusions:The risk factors for intracerebral hemorrhage include hypertension,family history of cerebrovascular disease,high salt diet,smoking,alcohol consumption,snoring disease,diabetes mellitus,overweight,high diastolic blood pressure,high systolic blood pressure and increased BMI.

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Objective To observe the cell proliferation inhibition of DNA methyltransferase (DNMT) inhibitors decitabine (DAC) combined with daunorubicin (DNR) in human leukemia cell line HL-60.Methods The effects of DNR and DAC were examined in HL-60 cells by cell viability using MTT method,and cell death using flow cytometric (FCM).Results DAC,DNR single drug application showed their effects on cell proliferation was dependent of dose and time,the inhibition effect of combined treatment group was much clearer [inhibition ratio of 72 hours was (80.23±1.71) ％,P ＜ 0.001].The highest apoptosis rate was at 5.0 μmol/L DAC combined with 1.0 μmol/L DNR for 72 hours,which was statistic significant (F =30.199,P ＜ 0.001).Combinations of different concentrations of DAC and DNR increased expression of PTEN mRNA in concentration-dependent manner,which was significantly higher than the control group and DNR single drug group (F =578.218,P ＜ 0.001).Conclusions DAC can significantly inhibit the proliferation of HL-60 cells and induce apoptosis,synergistic effect can be observed when DAC combined with DNR.The underlying mechanism can be due to DAC demethylation effect to increase PTEN mRNA expression.