The long-year program for medical education is the major way to train the high level medical professionals.This paper colleeted the research papers on this topic published in Chinese journals in recent years,extracted their key words and counted the high frequent key words According to the co-occurrence of a pair of key words in one paper.these high frequent keywords were clustered into groups.The research structure and main directions of the long-year program were outlined as the study of macro-planning of long-year program,the study of teaching models and teaching system,study of teaching practice.These results could be a useful reference for the medical educational researchers and managers.

Objective To find a new method of tangential view of patello femoral joint. Methods 62 cases of lateral knee radiographs were studied. The knee flexion angles, patello femoral angles, patello tibial angles and frontal patello tibial angles were measured and their relationships analyzed. The knee flexion angles and the patello femoral angles had linear relationship with a linear equation = 2 + 0.8x . The angles of posterior patellar line with tibial long axis and frontal tibial line were 3.3? and 12.7?respectively. According to the measurement results, an accessary positoning table was designed. The patients′ patello femoral joints were examined with the knee flexed at an angle of 30?. The patients were in supine position and the central X ray was angled at 73?vertically toward the film. Results 58 patello femoral joints of 40 patients were radiographically studied (10 males, 30 females) .All radiographs were classified into 4 degrees as Grade A, B, C and D. Eighteen cases were Grade A (31%), 30 cases were Grade B(52%), 8 cases were Grade C(18%)and 2 Grade D(3%).The reason for Grade D was due to small or negtive anterior patellotibial angles. Conclusion This new method of tangential view of patello femoral joint is accurate, comfortable and simple and could be used as routine examination for patello femoral joint diseases.

Objective To analyze multislice CT characteristics of intestinal obstruction transition zone caused by different patholo-gy.Methods 67 cases of intestinal obstruction were collected in our hospital.Multislice spiral CT scan combined with multi-plane re-organization (MPR)of the bowl obstruction transitional zone were analysed.Results Among 67 cases of intestinal obstruction,there were 28 cases of simple mechanical intestinal obstruction,1 7 cases adhesion intestinal obstruction,5 cases paralytic intestinal obstruc-tion,4 cases internal hernias and 4 cases mixed intestinal obstruction.Conclusion Intestinal canal transitional zone and arounding tis-sues of intestinal obstruction have certain characteristics for the same pathology which can be clearly displayed by multislice CT scan combined with MPR.

Objective:To compare the visual quality of patients with astigmatic multifocus intraocular lens (ART IOL) and astigmatic monofocus IOL (Toric IOL) after implantation.Methods:A prospective, non-randomized, controlled study was conducted to include 72 eyes of 72 cataract patients with corneal astigmatism (1.0-2.5 D) who were scheduled to receive phacoemulsification combined with IOL implantation in Chaoju Eye Hospital of Inner Mongolia from July 2017 to October 2018.Patients were divided into ART IOL group (37 eyes) and Toric IOL group (35 eyes) according to different IOLs implanted.All patients were followed up for 1 year after surgery.The main and secondary outcome indicators were compared.The main outcome indicators included distance (5 m), intermediate (80 cm), and near (40 cm) uncorrected visual acuity and best corrected visual acuity, defocus curve, contrast sensitivity, postoperative IOL rotation and residual astigmatism, while the secondary outcome indicators included visual subjective symptoms and spectacle independence rate.The above outcome indicators were compared between the two groups.This study followed the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Chaoju Eye Hospital of Inner Mongolia (No.CJYKLL202012).Written informed consent was obtained from each patient before surgery.Results:There was no statistically significant difference between the two groups in average uncorrected distance visual acuity and best corrected distance, intermediate and near visual acuity (all at P>0.05).The average intermediate and near visual acuity in the ART IOL group was significantly higher than that in the Toric IOL group, showing statistically significant differences (both at P<0.05).The defocus curve of the ART IOL group presented a double peak, which reached the peak at the far focus (0.0 D) and near focus (-2.5 D), respectively.The visual acuity range from 1.5 to-3.0 D was above 0.2 logarithm of the minimum angle of resolution (LogMAR), and the focus depth range was 4.5 D (1.5 to -3.0 D).The defocus curve of the Toric IOL group had only one crest, which was located at best corrected visual acuity (0.0 D).The visual acuity reached 0.2 LogMAR or above were from 1.0 to -1.0 D, and the focal depth range was 2.0 D (1.0 to -1.0 D).There was no statistically significant difference in contrast sensitivity at different spatial frequencies between the two groups in bright light, bright flashing light and dark light (all at P>0.05), while the contrast sensitivity of the ART IOL group at high dark flashing light frequency was lower than that of the Toric IOL group, showing statistically significant difference ( P<0.05).In the ART IOL group and the Toric IOL group, the average residual astigmatism after surgery was (-0.47±0.51)D and (-0.49±0.42)D, respectively, with no statistically significant difference ( t=0.408, P>0.05).There was no significant difference in postoperative IOL rotation between the two groups ( t=1.906, P>0.05).The total postoperative spectacle independence rate in the ART IOL group was 97.30%(36/37), which was higher than that in the Toric IOL group (17.14%, 6/35), showing statistically significant difference ( χ2=15.320, P<0.05). Conclusions:Both Toric IOL and ART IOL can better correct corneal astigmatism and improve patients' distance visual acuity, but ART IOL implantation can provide better distance, intermediate and near visual acuity, and higher spectacle independence rate.

Brucellosis ; China ; Epidemics ; Humans

Objective To determine retinal charges in newly diagnosed acute leukemia patients and to eval-uate the diagnostic value of retinal findings in patients with central nervous systerm leukemia(CNSL) and intracranial hemorrhage(IH). Methods 123 patients with acute leukemia(86 had myeloid leukemia and 37 had lymphoid leuke-mia) aged 14～77 years were examined with direct/indirect ophthalmoscopy for the presence of intraretinal hemorrha-ges (IRH), white-centred hemorrhages (WCH) and cotton-wool spots (CWS) within 5 days of diagnosis. Results CNSL and IH were more common in patients with retinopathy than those without (27.1% vs 9.1%, P=0.046; 29.2% vs 9.1%, P=0.029;respectively). Complete remission(CR) rate in patients with IRH was lower than those without(52.5% vs 80.5%, P =0.08). No association was found between the presence of WCH or CWS and CR rate. Conclusion The present study shows that patients with IRH is an indicator of poor prognosis in acute leukemia. Leukemic retinopathy usually is seen in patients with IH. Invasion of the eye by leukemia is not rare and indicates the need for early ophthalmological examination.

Objective To evaluate the changes of C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) in cerebrospinal fluid and serum of patients with intracranial infection,in order to explore their significance.Methods The levels of CRP and MMP-9 in 43 cases patients with intracranial infection of the acute and recovery phase and 21 normal people (control group) were determined by immunohistochemical turbidimetric method and radioimmunity method.In 43 patients,24 cases of viral encephalitis (viral encephalitis group),12 cases of tuberculous meningitis (tuberculous meningitis group) and 7 cases of purulent meningitis (purulent meningitis group).Results The levels of CRP of cerebrospinal fluid and serum in the acute phase in tuberculous meningitis group [(7.12 ±2.32),(28.84 ±4.91) μg/L] and purulent meningitis group [(8.68 ± 2.32),(32.60 ± 6.94) μg/L] were significantly higher than those in control group [(3.20 ± 1.62),(9.96 ± 3.45) μ g/L] (P ＜0.05);the levels of CRP had no significantly statistical difference in the acute and recovery phase between viral encephalitis group and control group (P＞0.05),and there was no significant difference in the levels of CRP of cerebrospinal fluid and serum in the recovery phase between tuberculous meningitis group or purulent meningitis group and control group (P＞0.05).There was no significant difference in the levels of CRP in tuberculous meningitis group and purulent meningitis group between the acute phase and recovery phase (P＞0.05).The levels of MMP-9 in the acute and recovery phase of all the groups were significantly higher than those in control group (P ＜0.05).The levels of MMP-9 in the recovery phase of all the groups were significantly decreased,compared with those in the acute phase (P＜0.05).Especially the levels of MMP-9 in the acute and recovery phase in tuberculous meningitis group and purulent meningitis group were significantly higher than those in viral encephalitis group (P＜0.05).There were no significant difference in the levels of MMP-9 in tuberculous meningitis and purulent meningitis group between the acute phase and the recovery phase (P＞0.05).Conclusions There is no significant relationship between CRP and viral encephalitis,however the levels of CRP are significantly increased in the acute phase of bacterial intracranial infections.The levels of MMP-9 in the three kinds of intracranial infection are signifcanfiy increased,especially in tuberculous meningitis and purulent meningitis patients,and they gradually decrease during the recovery procedure.The changes of CRP and MMP-9 would help to determine the phases,the kinds,the severity and the prognosis of intracranial infection.

Impulse oscillometry system(IOS) is a new pulmonary function test in recent years, IOS has been developed as a patient-friendly lung function test that minimizes demands on the patient, a noninvasive method without pain, the results is objective and comprehensive, suitable for all patients, especially for the elder ly, children, coma patients, pregnant women and critically ill patients, for better detection, diagnosis, and treat ment of different respiratory diseases.This article is to determine the reference values of IOS, its utility in children, the existing questions and its development prospect.

Objective:To develop a compound erythromycin nose drops,according to the pathology of rhinitis and characteristics of medicines.　Methods:This compound consists of two components:a solid component (capsule containing pulvis of erythromycin lactobionat) and a liquid component (the water solution of diphenhydramine hydrochloride and ephedrine hydrochloride). When using,you have only to put the collocystis to the liquid and sway to achieve thixotropy.　Results:This compound medicine mainly apply to acute and chronic as well as allergic rhinitis. A clinical observation of 180 cases showed an effective rate of 91.11% and a cure rate of 68.33% using this compound we developed. When observing another group of patients (totally 169 cases),an effective rate of 57.99% and a cure rate of 30.77% were achieved by using chloramphenicol and ephedrine nasal drops. The difference between this two medicines is notable.　Conclusion:The technique for preparing this compound medicine is simple and easy,the raw materials easy to get,and the price cheap. This preparation is effective in the treatment of rhinitis and worth popularizing.

Breast milk is the normative standard for infant nutrition and contains a wide variety of proteins that contribute to its unique qualities.Bile salt-stimulated lipase and amylase assist in the digestion and utilization of micronutrients and macronutrients from the milk.Several proteins with antimicrobial activity,such as immunoglobulins,lactoferrin,k-casein,lysozyme and lactoperoxidase,are relatively resistant against proteolysis in the gastrointestinal tract and may,in intact or partially digested form,contribute to the defense of breastfed infants against pathogenic bacteria and viruses.Cytokines,colony stimulating factor and chemokine have immunomodulatory activities,whereas insulin-like growth factor,epidermal growth factor and peptides from caseins are likely to be involved in the development of the intestinal mucosa and other organs of newborns.In combination,breast-milk proteins assist in providing adequate nutrition to breastfed infants while simultaneously aiding in the defense against infection and facilitating optimal development of important physiologic functions in newborns.