Objective To investigate the effects of combined epidural block with inhalation - intravenous general anesthesia (GE) on stress response in thepatients for laparoscopic radical colonectomy. Methods Twenty-eight ASA I-II patients scheduled for laparoscopic radical colonectomy were randomly divided into group GE and inhalation-intravenous general anesthesia group(group G) with 14 cases each. In group GE, epidural blocks were operated before induction, MAP,ECG ,HR,SpO2 and PETCO2 were observed and recorded at such point-time: pre-pneumoperitoneum and 1,2,3 h after pneumoperitoneum. Arterial blood-gas analysis ,noradrenaline(NE) and adrenaline(E) were also measured at the same time; Group G was the same as group GE except for no epidural block and extra fentanyl. Results The level of stress response hormones(NE and E) of post- pneumoperitoneum 1,2,3 h were increased VS those of pre-pneumoperitoneum in both groups, and group G was significant (P