A questionnaire survey was taken on the subjects administered an investigational new drug in order to look into their attitude toward a clinical testing and assessment of the work of the pharmacists clinical research coordinating the testing. Questionnaires were sent to 75 outpatients who were tested on with a new drug between January 2001 and March 2006. 55 individuals responded to the inquiry. All the subjects were taken care of by the coordinators by turns. The major concerns to the testees when they participated in the trial were the adverse reactions and efficacy of the new drug. Of the subjects who felt uneasy, 79.4% cited the adverse reactions and 50% about the efficacy. Some 80% of the respondents said they were satisfied with the explanation given beforehand about the nature of the clinical testing. The majority of the subjects, when they were in a fix, turned to pharmacist clinical reave coordinators for advice, not the physician nor nurses. The guidance given by the clinical reave coordinators about medication was generally received favorably. From the above-mentioned findings, it was made clear that the pharmacists clinical research coordinating the clinical trial played an important role as consultants in alleviating the anxiety of the testees during the trial. In the future, pharmacists will do the best to measure up to the expectations as coordinators in the clinical trial of new drugs by improving care of the testees individually while taking into their backgrounds and wishes into full consideration.
Clinical ; Questionnaires ; Clinical Trials ; Clinical Research ; Testing

Biomedical Research ; Clinical Medicine ; Humans

There are no signs of a drop in the number of deaths in accidents while at farmwork, hovering around 400 a year. Furthermore, the fact remains that accurate data about those farm accidents are not fully grasped.This reality gave birth to a Special Study Team on the Prevention of Farmwork Accidents in the Japanese Association of Rural Medicine.To cast light on the actuality of farm work accidents, questionnaires on accidents caused by farm machinery and instruments were sent to three medical institutions affiliated with the Association from October 2002 to March 2004. As a result, clinical data were collected on 141 clinical cases. Moreover, studies were performed on five cases in which rescue squads were dispatched to give aid to the injured.The data thus collected on the clinical cases revealed that grass cutters, harvesters, riding and push-on-foot types of tractors, and straw cutters were responsible for many accidents. Some individuals were involved in the accidents as operators of grass cutters were unaware of their existence nearby because of noise from the machines, some dragged in by the harvesters or straw cutters, and some pinned under the tractors.Case studies on death-induced accidents suggested the indispensability of fitting a safety frame and a seat belt to the tractor and installing a cabin on the speed sprayer.For the prevention of accidents by farm machinery, it is important to hold lecture meetings more frequently both on the basic method of their use and on first aid.
Prevention ; Clinical ; Accidents ; Industrial machine, NOS ; Research

OBJECTIVEIn order to provide readers with general concepts and methodology on adaptive designs for clinical trial.

METHODSDefinition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.

RESULTSThe relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced.

CONCLUSIONAdaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.

Clinical Trials as Topic ; methods ; Humans ; Research Design

Humans ; Research Design ; Clinical Trials as Topic

Real world study (RWS), a further verification and supplement for explanatory randomized controlled trial to evaluate the effectiveness of intervention measures in real clinical environment, has increasingly become the focus in the field of research on medical and health care services. However, some people mistakenly equate real world study with observational research, and argue that intervention and randomization cannot be carried out in real world study. In fact, both observational and experimental design are the basic designs in real world study, while the latter usually refers to pragmatic randomized controlled trial and registry-based randomized controlled trial. Other nonrandomized controlled and adaptive designs can also be adopted in the RWS.
Clinical Studies as Topic ; Humans ; Registries ; Research Design

PURPOSE: The aim of this study was to identify the research trends of articles published in the Journal of Korean Clinical Nursing Research from 2000 to 2017 by a text network analysis using keywords. METHODS: This study analyzed 600 articles. The R program was used for text mining that extracted frequency, centrality rank, and keyword network. RESULTS: From 2000 to 2009, keywords with high-frequency were ‘nurse’, ‘pain’, ‘anxiety’, ‘knowledge’, ‘attitude’, and so on. ‘Pain’, ‘nurse’, and ‘knowledge’ showed a high centrality. ‘Fatigue’ showed no high frequency but a high centrality. Keywords such as ‘nurse’, ‘knowledge’, and ‘pain’ also showed high frequency and centrality between 2010 and 2017. ‘Hemodialysis’ and ‘intensive care unit’ were added to keywords with high frequency and centrality during the period. CONCLUSION: The frequency and centrality of keywords such as ‘nurse’, ‘pain’, ‘knowledge’, ‘hemodialysis’, and ‘intensive care unit’ reflect the research trends in clinical nursing between 2000 and 2017. Further studies need to expand the keyword networks by connecting the main keywords.
Clinical Nursing Research ; Data Mining ; Nursing ; Nursing Research

Fellowship programs serve as alternative means to bridge the gap between undergraduate education and nursing practice. The purpose of the study was to develop a framework for a Clinical Nursing Research (CNR) Fellowship Program in the Philippines. A sequential non-dominant mixed method design was used. It comprised the following: identifying the competencies needed by clinical nurses in research and EBP; the training needs of clinical nurses in research and EBP; the core competencies, functional competencies and tasks of CNR fellows; and describing potential fellows' reactions and preferred ways of learning. Categorical analyses were done to analyze qualitative data. Descriptive statistics was used to analyze training needs and consensus agreement of experts. There were nine core competencies and 70 tasks of a CNR fellow that were distributed to the Beginner, Intermediate and Advanced Levels. Potential fellows prefer learning that is active, reflective, sequential, cooperative, guided by experts, personalized and involves use of technology. After learning the basics, they would need to learn more intensively on competencies that would help them become more capable of contributing to clinical practice. The CNR Fellowship Program framework seemed to contain contextually-relevant core competencies in clinical nursing research that are needed to augment basic nursing research education and to benefit clinical nursing practice.

Human ; Male ; Female ; Adult ; Fellowships And Scholarships ; Clinical Nursing Research ; Consensus ; Nursing Education Research ; Learning ; Technology ; Research

Fellowship programs serve as alternative means to bridge the gap between undergraduate education and nursing practice. The purpose of the study was to develop a framework for a Clinical Nursing Research (CNR) Fellowship Program in the Philippines. A sequential non-dominant mixed method design was used. It comprised the following: identifying the competencies needed by clinical nurses in research and EBP; the training needs of clinical nurses in research and EBP; the core competencies, functional competencies and tasks of CNR fellows; and describing potential fellows' reactions and preferred ways of learning. Categorical analyses were done to analyze qualitative data. Descriptive statistics was used to analyze training needs and consensus agreement of experts. There were nine core competencies and 70 tasks of a CNR fellow that were distributed to the Beginner, Intermediate and Advanced Levels. Potential fellows prefer learning that is active, reflective, sequential, cooperative, guided by experts, personalized and involves use of technology. After learning the basics, they would need to learn more intensively on competencies that would help them become more capable of contributing to clinical practice. The CNR Fellowship Program framework seemed to contain contextually-relevant core competencies in clinical nursing research that are needed to augment basic nursing research education and to benefit clinical nursing practice.

Human ; Male ; Female ; Adult ; Fellowships And Scholarships ; Clinical Nursing Research ; Consensus ; Nursing Education Research ; Learning ; Technology ; Research

PURPOSE: This study was conducted to generate theoretical constructs on depression from the study data by examining and interpreting Korean housewives' experience with depression to elicit its meaning, understand it better, and develop empirical knowledge on it. METHODS: The data were collected in a community public mental health center between April 1, 2012 and September 30, 2012 using in-depth interviews and theoretical sampling. The participants were 12 women aged 40-64 years who scored 7 or higher in the Korean version of the 21-item Hamilton Rating Scale for Depression (Kim, 1980). Collected data were analyzed by grounded theory methodology using open, axial, selective coding process. RESULTS: It was found that the basic socio-psychological process of Korean housewives' living through depression could be summarized into the following four phases: (1) the vanishing of the self into thin air, (2) becoming an empty shell, and (3) searching for the meaning of life, (4) fulfilling of an empty shell. CONCLUSION: This study may enhance the culturally elusive understanding of Korean housewives' experience with depression. As they are living through a hollow empty shell which looks normal on the outside, so can't get support from their families. It's important to educate their families about depressive phases.
Clinical Coding ; Depression* ; Female ; Humans ; Mental Health ; Qualitative Research