Objective To study the clinic characteristics and the treatment of acute pancreatitis ( AP) with and without hyperlipidemia. Methods The clinical data of 99 patients in our hospital from Jan. 2013 and Dec. 2013 were studied. Patients were divided into the hyper-lipidemic acute pancreatitis ( HAP) group and the control group ( AP without hyperlipidemia) . All the patients received standardized clinical AP treatment. The patient’ s condition, plasma biochemical index, treatment outcome, length of hospital stay, cost, and relapse were ob-served. Results The proportion of severe pancreatitis of HAP group (13. 6%) was obviously higher than that of control group (7. 8%). Blood sugar and uric acid of HAP group were significantly higher than that of control group, and the average blood sugar of HAP group reached to 171% of the control group. And the blood amylase of HAP group was only 44. 5% of that in the control group. One year recur-rence rate of HAP group (13. 6%) was significantly higher than that of control group (2. 6%) with a singnificant difference (P<0. 01). Conclusion It is suggested that hyperlipidemia condition has significant relations with the condition, performance and outcome of acute pan-creatitis.