Objective To investigate folic acid combined with Qizhi Weitong granule on serum gastrin, sIL-2R and immune function in chronic atrophy gastritis patients of Hp positive.Methods 46 cases with Hp positive chronic atrophy gastritis were selected and randomly divided into two groups according to different treatment, 23 cases in each group.The control group were given folic acid tablet on the basis of conventional treatment, and the experimental group were treated on the basis of control group combined with Qizhi Weitong granule.The patients in two groups were all treated for three months.Serum gastrin, sIL-2R and T cell subsets levels were detected after treatment.ResuIts Compared with control group after treatment, the serum gastrin level of experimental group was higher (P<0.05), sIL-2R level was lower (P<0.05), CD4 +T, CD4 +T/CD8 +T were higher (P<0.05), and CD8 +T level was lower ( P<0.05 ) .ConcIusion Folic acid combined with Qizhi Weitong granule could significantly increase serum gastrin and CD4 +T level and reduce sIL-2R and CD8 +T level in chronic atrophy gastritis patients of Hp positive, as a guidance for clinical.

Objective To explore the prevalence and risk factors of knee osteoarthritis (OA) among the elderly in Tianjin. Methods Totally 2038 elderly in Tianjin were investigated from January 2010 to June 2011 according to protocol of APLA-COPCORD Core Questionnaire to identification of risk factors for knee OA. Results The prevalence rates of knee pain and knee OA were 23.1％ and 21.7％,respectively. Knee OA appeared much frequently in women than men (27.6 ％ vs.16.1 ％,x2 =46.893,P＜0.001 ) in the trend of increase with aging(x2 =764.34,P＜0.001).BMI in knee OA group [(25.4±3.3) kg/m2]was significantly higher than in non-knee OA group [(23.8± 2.9) kg/m2],(t =7.944,P＜0.001).Menopause age in female knee OA group was younger than in female non-knee OA group [(50.2±3.7) years vs.(52.8±4.1) years,t=7.665,P＜0.001].Binary logistic regression revealed that age,sex,BMI and age of menopause were risk factors of knee OA,and eating vegetable might prevent from osteoarthritis,whereas there were no significantly association between knee OA and the other factors such as smoking and drinking.Conclusions Age,female and overweight are identified as risk factors of knee OA.

Objective To analyze the clinical features of 385 postoperative thyroid nodules patients,and to compare the correlation affected by different factors between benign and malignant thyroid nodules.Methods Total 385 patients underwent thyroid operation in general surgery department of our hospital were enrolled.Their clinical data,ultrasonic scanning of thyroid,and pathological results were compared between benign and malignant thyroid nodules.Results (1)264 cases with benign nodules (68.57％) and 121 cases with malignant nodules (31.43 ％)were found among 385 cases.The average age of benign group was (48.1 ± 13.4) years old,while malignant nodules group was (45.6 ± 12.5) years old.(2) No gender difference was found between benign and malignant nodules group (P＞0.05).(3) According to body mass index (BMI),the highest prevalence of malignant nodules was in overweight group,followed by obesity group.(4) Fasting blood glucose was (5.61 ± 1.07) mmol/L in benign group and (5.86±1.21) mmol/L in malignant group(P＜0.05).(5) Thyroid-stimulating hormone (TSH) in benign nodules group was (1.62 ± 1.30) mIU/L,while in malignant nodules group,which was (2.02 ±2.59) mIU/L(P＜0.05).(6) Irregular shape,unclear boundary,calcification,and lymph node metastasis were more frequent in malignant group than those in benign group under ultrasonic scanning (P＜0.05).(7) Logistic regression analysis revealed that the existence of thyroid cancer was significantly associated with age,fasting blood glucose,ultrasonic images(lymph node metastasis,irregular shape,and calcification).Conclusion (1) Fasting blood glucose levels and TSH in the malignant nodules group are higher than those in the benign group.(2) A negative correlation exists between age and thyroid cancer prevalence.(3) Ultrasonic images,including lymph node metastasis,irregular nodule shape,and calcification,may suggest the high possibility of thyroid cancer.

Objective To investigate the role of glycogen synthase kinase -3beta(GSK3β)on invasion and metastasis of human osteosarcoma cells .Methods Expression and phosphorylation of GSK 3βwere examined in osteosarcoma cell lines and tumor tissue from osteosarcoma patients by Western blot .The effects of small mole-cule GSK3βinhibitors on cell metastasis were detected by cell invasion assay and cell migration assay .Results Osteosarcoma cell lines showed increased GSK 3βexpression and abnormal activity regulation .In tumor tissue of patients with osteosarcoma metastasis and non -metastasis,GSK3βwere detected expression and abnormal activi-ty,especially in tumor tissue of the patients with osteosarcoma metastasis .Inhibition of GSK3βactivity resulted in inhibiting cells invasion and migration in osteosarcoma cell line .Conclusion In this research,we demonstrated that GSK3βencouraged osteosarcoma cells metastasis .The result will open up a potential target for clinical treat-ment of osteosarcoma .

Glioma is the most common primary brain tumor in adults and is essentially a polygenic abnormal disease. Solute carrier family 7 member 11 (SLC7A11) is a core component of the cystine/glutamate transporter and its expression is regulated at the transcriptional and translational levels. SLC7A11 mediates glioma cells proliferation, invasion and chemoradiotherapy resistance through regulation of oxidative stress and ferroptosis. Deep study of SLC7A11 will provide new theoretical basis and therapeutic targets for the treatment of gliomas.

Objective:To explore the difference between the prevalence of metabolic syndrome (MetS) and its influencing factors between rheumatoid arthritis (RA) patients and osteoarthritis (OA) patients.Methods:2 024 patients with RA were selected as the experimental group inthe First Central Hospital of Tianjin from January 1, 2014 to March 12, 2019. A total of 1 271 patients with OA who were treated at the same time served as the control group.Relevant indicators were measured, and correlation analysis was performed using logistic regression.Results:The prevalence of MetS in the past six years did not differ significantly inpatients with RA ( χ2=5.77, P=0.06) and OA ( χ2=1.11, P=0.57). MetS risk factors were more prevalent inpatients with OA, and the prevalence of MetS in patients with OA was also higher than patients with RA ( χ2=19.07, P<0.01). In logistic regression model, the prevalence of MetS was positively correlated with body weight {RA: 1.14[(95% CI(1.10, 1.18), P<0.01]; OA: 1.11[95% CI(1.07, 1.16), P<0.01]}, blood levels of triglyceride {RA:2.64[95% CI(1.58, 4.40), P<0.01] and OA: 2.91[95% CI(1.32, 6.43), P=0.01]}, and glucose {RA:1.67[95% CI(1.42, 1.97), P<0.01] and OA: 1.76[95% CI(1.31, 2.35), P<0.01]}, and negatively correlated with blood level of high-density lipoprotein cholesterol{RA: 0.09[95% CI(0.02, 0.32), P<0.01] and OA: 0.03[95% CI(0.01, 0.25), P<0.01]} in patients with RA and OA. MetS risk factors such as serum creatinine (Scr) only presented in RA patients 1.04 [ OR: 95% CI(1.01, 1.06), P<0.01]. Conclusion:The prevalence of MetS did not decrease in patients with chronic inflammatory arthritis in the past six years, and OA patients havea greater risk of MetS.

Objective:To examine the associations between serum magnesium (Mg) concentration and metabolic syndrome (MetS), diabetes (DM), hypertension (HTN), hyperuricemia (HU) in rheumatoid arthritis (RA) patients.Methods:From June 29, 2013 to February 29, 2019, 1 009 RA patients were collected at Tianjin First Central Hospital. The Mg concentration, clinical and laboratory indicators, living habits and medication were collected. The multivariate adjusted Logistic regression model was used to evaluate the relationship between Mg and MetS, DM, HTN, and HU.Results:Compared with the lowest quintile serum magnesium, In the MetS regression analysis, OR and 95% CI were 0.26 [95% CI(0.09, 0.76), P=0.01)], 0.17 [95% CI (0.06, 0.47), P<0.01], 0.27 [95% CI(0.09, 0.76), CI=0.01], and 0.22 [95% CI(0.09, 0.58), P<0.01], in second, third, fourth, and fifth (highest) quantiles of serum Mg, respectively, P for trend <0.01. In DM regression analysis, after adjusting for multiple potential confounders in Model 2, OR and 95% CI were 0.58 [95% CI (0.35, 0.96), P=0.03], and 0.51 [95% CI (0.29, 0.89), P=0.02], in third and fifth quantiles of the serum Mg, respectively, P for trend =0.01. But in model 3 this correlation disappears. HTN and HU were not associated with serum Mg ( P>0.05), P for trend >0.05. Conclusion:There was a negative correlation between serum Mg concentration and MetS in RA patients, But no correlation with HTN, HU. After adjusting the glomerular filtration rate, the negative correlation between serum Mg and DM also disappeared.

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and the spinal attachment point and is the most common type of spondyloarthritis (SpA). The pathogenesis of AS is related to both the immune system and the skeletal system. The main pathological changes include enthesitis, osteogenesis changes, osteolytic bone destruction, and immune system changes. Bone cells interact with immune cells, secrete a series of inflammatory factors, and jointly regulate the pathogenesis of AS. The imbalance of various immune cells in AS and the changes in inflammatory cytokines lead to a disorder of bone metabolism. At the same time, the osteocytes express various inflammatory cytokines, which leads to an imbalance of the immune system. The interaction between the immune system and the skeletal system has become a hot spot in the pathogenesis of AS. Understanding the bone immunological mechanism of AS will help to understand the exact pathogenesis of the disease and explore new treatment methods for it. In this review, the changes of various immune cells and inflammatory cytokines in AS and their effects on the skeletal system, as well as the changes of various osteocytes in the skeletal system and their effects on the immune system, were reviewed, and the latest progress in the treatment of AS was summarized.