Objective To summarize early complications and treatment after regional pancreatectomy for periampullary carcinoma. Methods Clinical data of 325 periampullary carcinoma cases in our hospital from Dec 1997 to Jul 2004 were collected. Postoperative early complications were analyzed. Results There were 109 cases from Dec 1997 to Dec 2001 and 216 cases from Jan 2002 to Jul 2004. Early complications rate were 21/109( 19. 3% ) and 18/216(8. 3% ) respectively (P