1.Comparison of immunosuppression between demethylzeylasteral with Glucosidorum Tripterygll Totorum
Zongming LIN ; Chunxing YANG ; Yongkang ZHANG
Chinese Journal of Organ Transplantation 2003;0(01):-
Objective To study the immunosuppression of Demethylzeylasteral (T-96) on the lymphocytic blastogenesis in vitro and compare the inhibitory effects on the rejection in renal transplant rats between T-96 with Glucosidorum Tripterygll Totorum (TII) in vivo. Methods Mixed lymphocyte cells were cultured through xenogenous antigen to stimulate C57BL/6 mouse spleen cell blast transformation, then different concentrations of T-96 or TII were added respectively. By 3H-TdR methods, the inhibitory effects of T-96 and TII on the blast transformation of spleen cells were measured. Different doses of T-96 or TII were given for different groups of renal transplant rats to evaluate the effects on survival time of renal transplant rats.Methods At the concentrations of 0.25 , 0.5 , 1.0 ??g/ml T-96, there was a significant inhibitory effect on the blast transformation of mouse spleen cells as compared with control group ( P
2.Clinical analysis of the early prognosis of the different ZEEK thrombus aspiration catheter application methods in acute ST-segment elevation myocardial infarction patients
Chunxing SUI ; Yanxin WANG ; Xue WANG ; Wei DANG ; Genqun DENG ; Yang JIANG ; Xiaoqun ZHENG
Chinese Journal of Postgraduates of Medicine 2013;(15):15-18
Objective To observe the ZEEK thrombus aspiration catheter use on the level of vascular and myocardial perfusion in acute ST-segment elevation myocardial infarction (STEMI) patients,as well as the impact of early prognosis in order to clear the relative best use of ZEEK thrombus aspiration catheter.Methods Eighty-eight acute STEMI patients who underwent percutaneous coronary intervention (PCI),according to the direct use of ZEEK thrombus aspiration catheter or after pre-expansion with small balloon,divided into direct aspiration group 45 cases,and inflation pre-aspiration group 43 cases.All patients underwent stenting,observed the perfusion of the vascular and myocardial levels after stenting,after 1 month,determined N end of B type natriuretic peptide (NT-proBNP) level,observed segmental wall motion score index (WMSI) and left ventricular ejection fractions (LVEF).Results Direct aspiration group was significantly better than inflation pre-aspiration group in the TIMI frames count,rate of TIMI coronary myocardial perfusion grade 2-3 grade and after 2 h ST segment resolution > 50% rate [(31.3 ± 7.9) frames vs.(42.5 ± 8.5) frames,84.4%(38/45) vs.72.1%(31/43),86.7%(39/45) vs.74.4%(32/43),P<0.01 or < 0.05].After 1 month,direct aspiration group was significantly lower than inflation pre-aspiration group in the peak of creatine kinase isozyme MB,NT-proBNP and WMSI [(2141.3 ± 306.5)U/L vs.(2734.5 ± 366.1)U/L,(443.2 ± 226.4) ng/L vs.(512.9 ± 281.7) nig/L,1.32 ± 0.16 vs.1.59 ± 0.23,P < 0.05],but there was no significant difference in LVEF between two groups (P > 0.05).Conclusions Repeated aspiration to infarction responsibility lesion segments using ZEEK thrombus aspiration catheter,and direct stenting,which is superior to the thrombus aspiration and stenting placement after single or multiple pre-expansion.
3. Clinical efficacy of hematoporphyrin monomethyl ether-based photodynamic therapy for the treatment of port-wine stain and its sonographic changes
Minmin SHENG ; Fang WANG ; Ruzhi ZHANG ; Chong WANG ; Li XIAO ; Yuhua YANG ; Yan LI ; Chunxing XU ; Xiaoming LIU
Chinese Journal of Dermatology 2019;52(12):923-927
Objective:
To evaluate the clinical efficacy of hematoporphyrin monomethyl ether-based photodynamic (HMME-PDT) therapy for the treatment of port-wine stain (PWS) and its sonographic changes.
Methods:
A total of 45 patients with confirmed PWS were enrolled from the Department of Dermatology, Third Affiliated Hospital of Soochow University from March 2017 to June 2018, including 5 with pink PWS, 39 with purplish red PWS and 1 with thickened PWS. All the patients received 3 sessions of HMME-PDT therapy. The skin thickness and density were compared before and after the treatment by using high-frequency ultrasound. Ranked data were analyzed by using nonparametric test. Measurement data were expressed as mean ± standard deviation, and analyzed using ony-way analysis of variance. Multiple comparisons were performed using Student-Newman-Keuls-