Advanced and recurrent cervical cancer has a poor prognosis and few effective therapeutic option.With the development of molecular biology,the targeted drugs for patients with locally advanced cervical cancer continuously appear,such as inhibiting human papillomavirus,targeting angiogenesis,epidermal growth factor receptor,mammalian target of rapamycin,cyclooxygenase-2,sarcoma gene,proteasome inhibitor,DNA methylation,etc.With the development of new molecular targeted therapy,more effective or even treatment measures of cervical cancer might be found,which can provid a new approach for the individualized treatment of cervical cancer.

Objective To explore the relationships between the cystoid type and the sclerous type polycystic ovarian syndrome(PCOS). Methods We compared the similarities and differences between the two types of PCOS by blood sex hormone measuring,laparoscopy,pathomorphology and so on in 19 patients with cystoid type PCOS,26 with sclerous type PCOS and 10 controlled age-matched non-PCOS women.Results There was no remarkable difference in the sex hormone level between the two groups of PCOS.Compared with the patients with cystoid type PCOS,the patients with sclerous type PCOS had longer course of disease,thicker ovarian tunica albuginea,more collagen,and hyperplasia medulla and stroma.Conclusion The cystoid type PCOS could develop into the sclerous type PCOS when the disease progressed.

Objective To explore the clinical characteristics and treatment in elderly patients with gastric bezoars. Methods Totally 49 patients with gastric bezoars were retrospectively analyzed,and among them,36 patients were aged 65-77 years, 48 cases underwent sequential therapy,1 elderly patient underwent surgical operation. Results There were differences in etiology, medical histories, clinical manifestations and therapeutic efficacy between elderly and non elderly patients with gastric bezoars.There were 42％ (15/36) of elderly patients eating glutinous rice cakes,4 cases with gastric surgery histories,6 cases with diabetes in elderly patients,but in non eldcrly patients only 8％ (1/13) of patients eating glutinous rice cake,and there were no cases with surgery histories and diabetes. Gastric bezoars in 48 cases were cleared away by sequential therapy. 1 elderly patient developed intestinal obstruction after surgical operation and died of infectious shock. Conclusions There are some different characteristics between elderly and nonelderly patients with gastric bezoars.Sequential therapy is safe and effective for elderly patients with gastric bezoars.

Objective To investigate the significance of neutrophil gelatinase associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in the patients of primary nephmpathy syndrome (PNS) complicated with acute kidney injury (AKI) by detecting urinary level of NGAL and KIM-1.Methods Senventy-two patients of PNS were selected as our subjects including 34 case with minimal change disease (MCD),23 cases with membranous nephropathy(MN),15 cases with mesangial proliferative glomerulonephritis (MsPGN).Fifteen cases of healthy physical examination were selected as control group.Meanwhile subjects were also divided into PNS with ATN group (15 cases) and PNS without ATN group (57 cases) according to their pathology check.ELISA was applied to detect the urinary level of NGAL and KIM-1,whose correlation with pathological type and clinical index were analyzed.Results The urinary level of NGAL and KIM-1 in patients with PNS were (42.37 ± 28.24) μg/L,(2.76 ± 1.11) μg/L respectively,higher than that of control group (P ＜0.01).The urinary level of NGAL in the MCD group,MN group,MsPGN group were higher than that of control group (46.81 ± 15.75) μg/L,(22.09 ± 7.69) μg/L,(15.31 ± 3.74) μg/L,(8.03 ± 0.35) μg/L respectively,P ＜ 0.05).The urinary level of NGAL in MCD group was significantly highest than that in the other groups (P ＜ 0.05).The urinary level of KIM-1 in the MCD group,MN group,MsPGN group were higher than that of control group(2.41 ±0.58) μg/L,(2.54 ±0.67) μg/L,(2.87 ±0.50) μg/L,(0.73 ±0.35) μg/L respectively,P ＜0.05).But there was no significant difference among MCD,MN,MsPGN groups(P ＞ 0.05).The urinary level of NGAL and KIM-1 in patients PNS were (42.37 ± 28.34) μg/L and (2.76 ± 1.11) μg/L,significantly higher than that of control group (t =4.668,12.665,P ＜ 0.05).The urinary level of NGAL and KIM-1 in patients PNS with ATN were significantly higher than patient without ATN (NGAL:(74.98 ±9.52) μg/L vs.(31.31 ±2.34) μg/L;KIM-1:(3.60 ±0.92) μg/L vs.(2.54 ±0.81) μg/L,P ＜0.05).The correlation analysis showed that the urinary level of NGAL and KIM-1 was positively correlated with serum β2-MG,serum creatinine,serum blood urea nitrogen and 24-hour urine protein.(r =0.432,0.299,0.234,0.254,0.434,0.650,0.276,0.301 respectively,P ＜ 0.05).Conclusion The urinary level of NGAL and KIM-1 could be considered as the early,non-invasive biologic factors to reflect in patients of PNS with ATN.

Objective To analyze the impac factors of serum N?terminal pro?brain natriuretic peptide (NT?proBNP) in patients with renal failure in non?dialysis phase, and to determine the cut?off point of as a diagnostic values in these patients with heart failure (HF). Methods Cross?sectional study was applied. Clinical data of 145 patients (37 cases of CKD4, 89 cases of CKD5, and 19 cases of acute renal injury (AKI) with renal failure in non?dialysis phase were collected. Comparison between groups and lineal regression analysis were utilized to investigate the impact factors of NT?proBNP, and the receiver operating characteristic curve (ROC curve) to select a better cut?off point of diagnosis in these patients with HF. Results (1) Compared with patients without HF, patients with HF had significantly higher edema, cardiac troponin I, serum phosphorus concentration, and left atrial diameter (LA), while ALB and left ventricular ejection fraction (LVEF) were decreased (P<0.05). (2) The NT?proBNP was divided into 4 groups with four points: First groups of 36 cases, NT?proBNP 1 ?862 ng/L, second groups 37 cases, 866?2670 ng/L, third groups 37 cases, 2790?20 000 ng/L, fourth groups 35 cases, 20 900?35 000 ng/L. With the increase of NT?proBNP levels, the occurrence of AKI and CKD4 decreased gradually while the occurrence of CKD and edema were significantly increased (P<0.01). Systolic blood pressure, troponin I, uric acid, serum phosphorus, parathyroid hormone, 24 hours urine protein, LA, interventricular septum thickness (IVS), left ventricular posterior wall thickness (LVPW) level gradually increased. Hb, ALB, calcium, CO2, eGFR, LVEF significantly decreased (P<0.01). The serum NT?proBNP of patients with HF was significantly higher than that of patients without HF (19 150 ng/L vs 1530 ng/L, P<0.01). The serum NT?proBNP of patients with edema was significantly higher than that in patients without edema (5460 ng/L vs 1630 ng/L, P<0.01). (3) Single factor linear regression analysis indicated that higher NT?proBNP was positive correlated with HF, edema, cardiac troponin I, uric acid, serum phosphorus, LA, IVS and LVPW (P<0.05), while negative correlated with Hb, eGFR, ALB, serum calcium, CO2, LVEF (P<0.05), and not correlated with eGFR, uric acid, serum calcium (P>0.05). (4) The best cut?off point of NT?proBNP predicting HF in patients with renal failure in non?dialysis phase was 3805 ng/L, AUC=0.848, 95%CI 0.786?0.910. Sensitivity was 82.4%, specificity 74.5%, positive predictive value 62.1%, negative predictive value 87.3%, positive likelihood ratio 3.2, negative likelihood ratio 0.24. Conclusions The level of NT?proBNP>20 000 ng/L is mainly found in end?stage renal disease patients with HF. HF is a main factor for the increase of NT?proBNP in patients with renal failure in non?dialysis phase. High phosphorus viremia, anemia, and hypoalbuminemia are closely related to NT?proBNP. Therefore NT?proBNP predicting HF should take into account the effects of these confounding factors in these patients.

Objective To investigate the effect of a fast-track based clinical nursing pathway of hepatic carcinoma on patient satisfaction and job satisfaction of nurses. Methods A total of 91 primary hepatic carcinoma (PHC) patients undergoing elective hepatectomy were enrolled and were divided into two groups by admission time, namely the control group (48 cases) and the experimental group (43 cases). The patients in the control group received traditional perioperative nursing care of hepatectomy, while the cases in the experimental group participated in fast-track nursing pathway. Patient satisfaction and nurse job satisfaction were measured before and after implementation. Results Final analysis included 45 patients in the control group and 40 patients in the experimental group. In the experimental group, the total score of patient satisfaction and the scores of all dimensions (including services and techniques, concern and care, services and techniques and overall satisfaction) were (132.75 ± 13.71), (48.30 ± 6.53), (42.60 ± 4.62), (35.98 ± 3.85), (5.88 ± 0.94), while they were (122.89 ± 16.62), (44.53 ± 7.74), (39.49 ± 5.67), (33.53±4.40), (5.33±1.13) in the control group. And the scores of the experimental group were significantly higher than that of the control group (t=-2.961, t=-2.409, t=-2.753, t=-2.709, t=-2.389, P<0.05). Furthermore,after implementing the fast-track clinical nursing pathway,the total score of nurse job satisfaction and the scores of six factors were (143.23 ± 9.40), (28.45 ± 2.72), (24.82 ± 2.28), (23.05 ± 1.33), (13.91 ± 1.95), (15.05 ± 1.43), (16.64 ± 1.65) while they were (127.36 ± 13.14), (25.68 ± 4.16), (19.64 ± 2.75), (20.23 ± 2.35), (13.23 ± 2.22), (13.68 ± 2.01), (14.50 ± 1.95) before the implementation. The former was significantly better than the latter (t =-12.462,-7.743,-12.670,-6.560,-2.417,-1.483,-6.587,P<0.05). However, no differences were observed in the other two dimensions of wages and benefits andwork-family balance(t =-1.945,-1.312,P>0.05) since the scores after implementation were (13.86 ± 2.12), (7.45 ± 1.57), while that of (13.18 ± 2.30)、(7.23 ± 1.41) were obtained before performance. Conclusions Application of fast- track nursing pathway in perioperative patients with PHC can contribute to promoting the level of patient satisfaction and job satisfaction of nurses and improving nursing quality. It is suggested that this nursing pathway will have more potential value for PHC patients.

OBJECTIVE: To investigate the health safety of the offspring delivered following natural pregnancy after orthotopic fetal ovarian allotransplantation in rats. METHODS: Any symptoms of spontaneous abortion during pregnancy and of any possible still birth and death of infant rats within 3 days after the delivery were observed and compared in 19 pregnant rats (the study group) after the orthotopic fetal ovarian allotransplantation and in another 10 pregnant rats (the control group). Forty offspring rats from each group were selected randomly. The mean weight at day 35 after the birth of offsprings was measured and compared. By routine G-banding technique, the karyotype was analyzed and the chromosomal number and structure were observed. RESULTS: There was no spontaneous abortion, still birth, or death in the infants within 3 days after the birth in both groups. The body weight of offsprings at 35 days in both groups was (93.80 ± 4.93) g and (94.13 ± 4.53) g, respectively. There was no significant difference between the 2 groups (P> 0.05). The karyotype analysis indicated that the karyotype from both offspring groups was 42, XX or 42, XY. No chromosome abnormality (abnormal chromosomal number or abnormal chromosomal structure) was observed in both groups. CONCLUSION The health status of the offsprings of rats after orthotopic fetal ovarian allotransplantation is safe.
Animals ; Animals, Newborn ; Female ; Fetus ; Karyotype ; Male ; Ovary ; transplantation ; Ovulation ; physiology ; Pregnancy ; Pregnancy Outcome ; Rats ; Rats, Sprague-Dawley ; Transplantation, Homologous ; adverse effects

Objective:To understand the self-management needs of outpatient adolescent children with epilepsy, so as d to provide a theoretical basis for building a care model for children with epilepsy.Methods:Using the purposive sampling method, a total of 10 adolescent children with epilepsy who were treated in neurology clinic of a Class Ⅲ Grade A hospital affiliated to a medical university in Jiangsu Province were selected as the research objects from June 1 to December 31, 2020. Using qualitative research design, the semi-structured interview method was used to conduct in-depth interviews with the research objects. Data analysis was performed using Nvivo 10.0 software.Results:Through data analysis of the self-management needs of outpatient adolescent children with epilepsy, three themes were extracted, namely information needs, psychological support needs and social support needs.Conclusions:According to the analysis of the self-management needs of adolescent children with epilepsy in outpatient clinics, medical staff should focus on meeting the information needs of children, support children's psychological needs, strengthen social support, pay attention to the role of families and schools, adapt to the new situation, expand service areas and build suitable models of self-management care in adolescent children with epilepsy.

Objective:To explore the application effect of "Internet +" hospital-family-school care model for school-age children with epilepsy.Methods:Using the convenient sampling method, a total of 80 school-age children with epilepsy who were treated in Xuzhou Children's Hospital from January to December 2020 were selected as the research objects. According to the random number table method, they were divided into the observation group and the control group, with 40 cases in each group. The control group was given routine continuous care, while the observation group implemented the "Internet +" hospital-family-school care model on the basis of the control group. Before the intervention and 3 and 6 months after the intervention, the self-made drug compliance questionnaire and Quality Childhood Epilepsy Questionnaire (QOLCE) were used to investigate the medication compliance and quality of life of children in the two groups. A self-made parent satisfaction questionnaire was used to investigate satisfaction of parents before the intervention and 6 months after the intervention.Results:After 3 and 6 months of intervention, medication compliance and scores of five aspects in QOLCE of the observation group were all higher than those of the control group, and the differences were statistically significant ( P<0.05) . After 6 months of intervention, the parents' satisfaction was higher than that of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:The "Internet +" hospital-family-school care model can improve the medication compliance and quality of life of children and satisfaction of their parents with care and achieve a smooth transition from the hospital to the family and school, which is worthy of clinical promotion.

ObjectiveTo analyze the incidence and epidemiological characteristics of infectious diseases among the primary and secondary school students in Songjiang District, Shanghai, and to provide a scientific basis for the prevention and control of infectious diseases in schools. MethodsDescriptive epidemiological methods were used to analyze the types and numbers of infectious diseases among students in Songjiang District from 2018 to 2022. Furthermore, the incidence, constituent ratios and incidence precedence of infectious diseases were calculated simultaneously. ResultsA total of 5 543 cases of student infectious diseases were reported in Songjiang District from 2018 to 2022, involving 17 types of infectious diseases, with an annual incidence rate of 11.38‰. The reported infectious diseases were mainly respiratory infectious diseases (77.72%), followed by intestinal infections (21.88%). Chickenpox, influenza, and hand-foot-mouth disease were the top three infectious diseases according to the incidence rate, with a total of 3 966 cases reported, accounting for 71.55% of the total cases. More male cases were reported than females with a gender ratio of 1.44∶1. Infectious diseases were most prevalent among students aged between 6~<13 years (4 383 cases, accounting for 79.07%). The distribution of infectious diseases among students showed two peaks: from November to December and April to May. Jiuting Town, Xinqiao Town, and Chedun Town were the top three subdistricts (towns) in terms of incidence rate. ConclusionThe situation of infectious disease prevention and control among the primary and secondary school students in Songjiang District is severe, and monitoring and prevention of infectious diseases among students should be strengthened, especially respiratory infectious diseases.