Objective To study difference of coronary artery lesion between Han nationality and Uygur nationality patients with coronary artery disease .Methods 2008 patients with coronary artery disease were analyzed retrospectively in our hospital .The cor-onary artery lesion was evaluated by the number ,location ,type of coronary lesion and Gensini scores .Results The incidences of three-vessel disease in Uygur patients (40 .6% ) were higher than that of Han patients (35 .3% ) .Along with the age increasing , Gensini scores increased gradually .Gensini scores of uygur patients were significantly higher than those of Han patients in same age groups .Compared with the Han patients ,mean age in the Uygur patients was lower(P<0 .05) .Conclusion Severity of coronary artery disease increased with age ,single-vessel lesion gradually reduced and three-vessel lesion gradually increased .The coronary artery lesions of Uygur patients were more severe than those of Han patients in same age :more three-branch lesion .Compared with Han patients ,morbidity age of similarly degree coronary atherosclerosis in the Uygur patients maybe more early .