Objective To investigate the influence and the efficacy for lipid level of rosuvastatin with atorv-astatin in the treatment of coronary heart disease.Methods 160 patients with coronary heart disease were randomly divided into the observation group and the control group,80 cases in each group.The patients of the observation group were given rosuvastatin 10mg every night,the control group were treated with the same dose of atorvastatin every night,the efficacy before and after treatment were compared after continuous 21d,and the lipid changed of the two groups were compared.Results There were statistically significant difference in the lipid level of the observation group before and after treatment(t =3.728,4.516,5.322,3.143,all P <0.05),and after treatment the TC,TG,LDL-C levels of the observation group were lower than those of the control group,the HDL -C level was higher than that of the control group,the difference was statistically significant(t =3.512,5.529,6.325,3.139,all P <0.05);There were statistically significant differences in hs -CRP,Hcy,IMT of the observation group before and after treatment [(14.35 ±1.56)μmol/L vs (22.45 ±1.82)μmol/L,(0.31 ±0.03)g/L vs (0.45 ±0.06)g/L,(1.64 ±0.11)mm vs (2.03 ±0.12)mm](t =3.728,3.231,3.452,all P <0.05),and the hs -CRP,Hcy,IMT of the observation group were lower than those of the control group[(14.35 ±1.56)μmol/L vs (16.56 ±1.26)μmol/L,(0.31 ±0.03)g/L vs (0.38 ±0.05)g/L,(1.64 ±0.11 )mm vs (1.81 ±0.12)mm](t =3.512,3.529,4.325,all P <0.05 ). Conclusion The treatment effect and lipid level of rosuvastatin was superior to atorvastatin.

Objective To study the clinical value of peripheral venous blood circulating tumor cell count in patients with non -small -cell lung cancer (NSCLC).Methods 28 patients with NSCLC were chosen as observa-tion group,at the same time,16 patients with benign lung tumor and 16 healthy persons were chosen as the control group 1,2.Before and after treatment,the peripheral venous blood circulating tumor cell counts were studied to under-stand its value in clinical.Results CK -FITC expression rate of adenocarcinoma patients was 95.8%,CD326APC expression rate was 94.5%,CK -FITC and CD326APC expression rate was 94.6%.CK -FITC expression rate of squamous carcinoma was 93.7%,CD326APC expression rate was 93.9%,CK -FITC and CD326APC expression rate was 94.1%,the differences between the two groups were not significant (χ2 =2.89,1.36,2.14,all P >0.05).The positive rate of peripheral venous blood circulating tumor cells in the observation group was significantly higher than the two control groups,and before treatment,the positive rate of peripheral venous blood circulating tumor cell was higher than after treatment.Conclusion Peripheral venous blood circulating tumor cell count can determine the dis-ease development process.

Objective To study the effect and mechanism of polypeptide from Chlamys farreri(PCF) on the thymocytes damaged by 60Co γ-rays. Methods The ceils were randomly divided into six groups: control group, 60Co groups (2 Gy, model),60Co + 0.5% PCF, 60Co+ 0.25% PCF, 60Co + 0.125% PCF, 60Co +0.1% VitC. The concentration of GSH-Px, ROS, A-SAC, T-AOC and the cells' viability were determined. The mitochondria membrane potential were tested. The expressions of P53, Bax and Bel-2 proteins were examined.Results The activities f GSH-Px, A-SAC, T-AOC in cells were enhanced, and the amounts of ROS were decreased by PCF. The expression of Bcl-2 gene was up-regulated, and down-regulated for the expression of P53 and Bax. All observed indexes of the PCF groups were significantly different compared with model group (P <0.05). Conclusions PCF has the protective effects on damages of thymocytes caused by 60Co irradiation. The mechanisms might be related to inhibiting of lymphocyte apoptosis and enhancing the activities of lymphocytes.

BACKGROUND: Craniofacial hard tissue structures vary in age, gender, regional and racial differences. Some researchers have conducted X-ray cephalometric measures of malocclusion deformity in some domestic cities, and obtained normal cephalometric measures of craniofacial hard tissue structure. However, little data have been available concerning cephalometric measures of craniofacial hard tissue structure of Tibetan youth in Tibet region. OBJECTIVE: To observe structural features of craniofacial hard tissue of permanent tooth occlusal period in the adolescent of Lhasa. DESIGN, TIME AND SETTING: Stratified cluster sampling survey was performed at Naqu, Tibet from June to August 2008. PARTICIPANTS: A total of 200 adolescents at permanent tooth occlusal period, 100 males and 100 females aged 11-14 years were selected from middle and primary schools of Lhasa in 2003. The inclusion criteria included: teeth in order, neutral occlusal adjustment, normal maxilla and mandible appearance and relationship, normal teeth number and overbite and overjet, concordant face, and no history of orthodontic management. METHODS: According to the requirements and standards for the irradiation, 200 subjects underwent X-ray cephalometric measures, and the results were compared with normal values of the same age. MAIN OUTCOME MEASURES: SNA angle, SNB angle, ANB angle, 1-SA angle, 1-NA angle, 1-NA, T-MP angle, Y axial angle, NP-FH angle, NA-PA angle, 1-T angle, MP-SN angle, Po-NB, T-NB angle, T-NB, and MP-FH angle. RESULTS: No significant differences were found between Lhasa adolescents and normal values in terms of SNA angle, SNB angle, ANB angle, 1-SN angle, 1-NA angle, 1-NA, T-MP angle, Y axial angle, NP-FH, NA-PA, 1-T, and MP-SN. Po-NB was slightly greater than normal value and T-NB angle, T-NB and MP-FH were significantly less than normal values. CONCLUSION: Lhasa adolescents have significantly different craniofacial hard tissue structure from normal values: forward protrusion of mental region, flat mandible angle, straight mandible anterior teeth, upward and forward rotated mandible, and straight face type.

We have studied the inhibitory effect of polysaccharides mixture on Ehrlich Ascites Carcinoma (EAC), Sarcoma 180 (S180), reticulocytic leukemia (L615) in mice. It is found that polysaccharides mixture could obviously prolong the survival duration of mice suffering from tumour and inhibit neoplastic proliferation. Thymus and adrenal glands atrophy in mice caused by vaccination of cancer cells was also remarkably resisted.The results of our experiments show that polysaccharides mixture is a safe,effective and promising pharmaceutic preparation of traditional Chinese medicine. It deserves to be further studied and developed.

BACKGROUND:Craniofacial hard tissue structures vary in age,gender,regional and racial differences.Some researchers have conducted X-ray cephalometric measures of malocclusion deformity in some domestic cities,and obtained normal cephalometric measures of craniofacial hard tissue structure.However,little data have been available concerning cephalometric measures of craniofacial hard tissue structure of Tibetan youth in Tibet region.OBJECTIVE:To observe structural features of craniofacial hard tissue of permanent tooth occlusal period in the adolescent of Lhasa.DESIGN,TIME AND SETTING:Stratified cluster sampling survey was performed at Naqu,Tibet from June to August 2008.PARTICIPANTS:A total of 200 adolescents at permanent tooth occlusal period,100 males and 100 females aged 11-14 years were selected from middle and primary schools of Lhasa in 2003.The inclusion criteria included:teeth in order,neutral occlusal adjustment,normal maxilla and mandible appearance and relationship,normal teeth number and overbite and overjet,concordant face,and no history of orthodontic management.METHODS:According to the requirements and standards for the irradiation,200 subjects underwent X-ray cephalometric measures,and the results were compared with normal values of the same age.MAIN OUTCOME MEASURES:SNA angle,SNB angle,ANB angle,1-SA angle,1-NA angle,1-NA,?-MP angle,Y axial angle,NP-FH angle,NA-PA angle,1-? angle,MP-SN angle,Po-NB,?-NB angle,?-NB,and MP-FH angle.RESULTS:No significant differences were found between Lhasa adolescents and normal values in terms of SNA angle,SNB angle,ANB angle,1-SN angle,1-NA angle,1-NA,?-MP angle,Y axial angle,NP-FH,NA-PA,1-?,and MP-SN.Po-NB was slightly greater than normal value and ?-NB angle,?-NB and MP-FH were significantly less than normal values.CONCLUSION:Lhasa adolescents have significantly different craniofacial hard tissue structure from normal values:forward protrusion of mental region,flat mandible angle,straight mandible anterior teeth,upward and forward rotated mandible,and straight face type.

BACKGROUND: Presently, it is a certain preventive effect of local emplacement of various isolated materials during operation and postoperatively drug-controlled inflammatory reaction on adhesion between epidural and nerve root after laminectomy.OBJECTIVE: To study the preventive effect of chitosan and titanium net on epidural cicatricle adhesion after laminectomy.DESIGN, TIME AND SETTING: Randomized controlled animal study, which was performed in Guiyang Medical College from June to December 2005.MATERIALS: Eighty adult rabbits, weighing (2.0±0.2) kg, were used to establish vertebral plate resection models. Chitosan was provided by Shanghai Qisheng Biological Agent Industry Company, and titanium net by Guizhou Kelun Pharmacology Company Limited.METHODS: Eighty adult rabbits were randomly divided into four groups, including control group (0.5 mL saline), titanium net group (titanium net in the size of 1.0 cm × 0.8 cm was covered on defect region of vertebral plate and fixed on processus spinosus of upper and lower cone, bilateral muscles and soft tissues), chitosan group (2 mL chitosan), and chitosan + titanium net group (combination of chitosan and titanium net). Six rabbits were sacrificed in the 2nd and 4th weeks postoperatively, and eight rabbits were chosen as the samples in the 8th week.MAIN OUTCOME MEASURES: Morphological changes of cicatricle.RESULTS: Cicatricle was clearer in the control group. Titanium net could relieve peripheral cicatricle of dura mater and effectively isolate peripheral cicatricial tissue and spinal dura meter. Chitosan could remarkably prevent from cicatricle adhesion and inhibit inflammatory reaction. The combination of chitosan and titanium net could effectively inhibit proliferation of cicatricle surrounding dura meter.CONCLUSION: Association of chitosan and titanium net can effectively inhibit cicatricle adhesion surrounding dura meter after laminectomy.

60 kg) was given to all the patients 1-3 days after their operation.The pacing threshold and the amplitude of P and R waves on cardiograph were measured before injection and at 10,30,90,180 minutes afterwards.Results No significant changes were oburved in pacing threshold and the amplitade of P and R waves before and after the injection of metoprolol in patients with either newly implanted or replacement of permanent pacemakers.Conclusion Metoprolol tartrate has no effect on atrial and ventricular pacing threshold and the amplitude of P and R waves in patients with permanent pacemakers implantation.

Objective To investigate the mechanism of the protective effects induced by intrathecally remote morphine preconditioning (RMPC) against myocardial ischemia-reperfusion (I/R) injury in rats.Method Male SD rats weighing 280 ～ 320 g were used in this study. A needle was inserted through a surgically created hole into the spinal cord space. Sixty male SD rats, in which intrathecal needle was successfully placed without complication, were randomly (random number) divided into 10 groups of 6 animals each. In group Ⅰ myocardial I/R was produced (I/R). In group Ⅱ morphine was given intrathecally in 3 repeated doses of 1 μg/kg at 5 mtn intervals before ischemia (RMPC). Antagonists CGRP8-37 (CGRP receptor antagonist), 8-SPT (adenosine receptor antagonist), HOE-140 (bradykinin B2 receptor antagonist) and HEX (autonomic nerve antagonist) were given intrathecally in group Ⅲ , Ⅳ, Ⅴ and Ⅳrespectively at 10 min before RMPC. In group Ⅶ, Ⅷ, Ⅸ and X CGRP8-37, 8-SPT, HOE-140 and HEX were given intrathecally respectively at 40 min before ischemia. Myocardial I/R was produced by occlusion of left anterior descending branch (LAD) of coronary artery for 30 min followed by 120 min reperfusion. At the baseline and the end of 120 min reperfusion venous blood samples were taken for determination of LDH activity. The animals were then killed and hearts removed for measurement of area at risk (AAR) and infarct size area (IS). IS/AAR was calculated. Results The size of infarct area was smaller and IS/AAR ratio lower and significantly less LDH was released at the time of 120 min reperfusion in RMPC group (group Ⅱ) than in group I/R (group Ⅰ). The protective effects of RMPC was abolished by intravenously pretreatment with CGRP8-37, 8-SPT,HOE-140 and HEX. Conclusions CGRP, adenosine, bradykinin and autonomic nerve are involved in the protective effects of intrathecally remote morphine preconditioning against myocardial I/R injury.

Objective To discuss the effect of tetrandrine on endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats. Methods 78 rats were randomly divided into 3 groups: control group(n=36), Tet-treated group(n=36), sham-operated group(n=6). Control group and Tet-treated group were adapted with Allen's combat modeling method. Rats in Tet group were injected Ted with a dosage 22.5 mg/kg in 30 minutes, 24 hours and 48 hours after ASCI, and the same dose of saline was injected into injured group as control .Samples were dissected from the spinal cord injury sites at 1 day, 3 days, 1 week, 2 weeks, 3 weeks, 4 weeks after ASCI, and tested by HE staining for morphology and by immunolfuorescence staining for the expression of BrdU and nestin. Results A little Nestin positive cells and BrdU positive cells were found in control group and Tet-treated group at 1 day after injury. A large number of positive cells were found in both groups at 1 week after injury and reached the peak which lasted for 2 weeks and then decreased gradually. The expression of Nestin positive cells and BrdU positive cells in control group and Tet-treated group were decreased significantly at 4 weeks after injury, but were still more than that in sham operation group. The number of Nestin positive cells and BrdU positive cells in Tet-treated group were more than that in control group at each time point after injury. The expression was higher in Tet-treated group than control group at 1 day, 3 days, 1 week, 2 weeks, 3 weeks after injury and had no difference at 4 weeks after injury. Conclusions Tetrandrine could increase the number of Nestin positive cells, BrdU positive cells and endogenous neural stem cells though improving the microenvironment, and it is beneficial for the recovery of spinal cord injury in rats.