1.Effect of mitiglinide calcium on fasting plasma fibroblast growth factor-21 level in patients with newly diagnosed type 2 diabetes mellitus
Yingying FAN ; Gangyi YANG ; Ling LI ; Zhiyong LI ; Yong LIAO ; Chunrui CHENG ; Shiguo TANG ; Shengbing LI ; Na LI ; Yi WANG
Chinese Journal of Endocrinology and Metabolism 2012;28(2):143-145
Eighty-two newly-diagnosed type 2 diabetic patients with poor glycemic control were treated by mitiglinide calcium for 16 weeks.Plasma fibroblast growth factor-21 ( FGF-21 ) level were evaluated.The relationship of plasma FGF-21 levels with body mass index,body fat,waist-to-hip ratio,lipid,blood glucose,HbA1c,and free fatty-acid were analyzed.Plasma FGF-21 was decreased significantly by treatment with mitiglinide calcium in type 2 diabetic patients,and it may play a role in the pathogenesis of type 2 diabetes mellitus.
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