Objective:To confirm the analogue of Somatostatin OCT and NC 8 12 on the colon tumor cell growth in vitro and vivo.Methods:(1)Two colon cancer cell lines HCT116,LOVO of which cell proliferation was measured with MTT were treated with different analogue of Somatostatin in vitro.(2)The nude mice were implanted s.c.with colon cancer cell line HCT116,then were injected s.c. with OCT and NC 8 12.Results:(1).Cell proliferation of HCT116 induced by Insulin was obviously inhibited by OCT or NC 8 12 at 10 -8 mol/L 24h later after the cells were incubated with them.(2)The nude mice bearing xenografts of colon cancer HCT116 were treated for 21days subcontinuously with OCT?NC 8 12?g/(kg.d)],the inhibitory effect was seen obviously.,the inhibitory effect was seen obviously.Conclusion:The Somatostatin analogues OCT and NC 8 12 can inhibit the proliferation of colon cancer cells in vitro and vivo directly.

Objective To investigate the clinical and pathological features of meningeal carcinoma.Methods The clinical,cerebrospinal fluid(CSF)and immunocytochemistry data of 142 patients with meningeal carcinoma were analysis retrospectively.Results Clinical manifestation:headache were found in 123 cases(86.62%),and dizziness were found in 19 cases(13.38%).26 cases(18.31%)had fever and 10 cases(7.04%)had poor vision.CSF and immunocytochemistry:in all cases,EMA,CK were positive and CD14,GFAP were negative in all meningeal carcinomatosis.99 cases(69.72%)showed low molecule CK(+)and high molecule CK(-).These were adenocarcinoma.33 cases(23.24%)showed high molecule CK(+)and low molecule CK(-).These were squamous cell carcinoma.10 cases(7.04%)showed both high and low molecule CK(+).These were adenocarcinoma and squamous cell carcinoma.In 67 cases(47.18%),primary cancer were found in lungs.Tumors were found in gastrointestinal tract in 23 cases(16.20%),and in breast in 9 cases(6.34%).Other primary cancers were found in endomertrium(1 case),in ovarium(1 case)and in liver(1 case).In 37 cases(26.06%),primary cancer couldn't been found.Among the 105 cases which primary cancer were found,15 cases were drawn out.In other 90 cases,82(91.11%)died from 3 to 14 months after diagnosis.In the cases no primary cancer were found,6 cases were drawn out.In other 31 cases,28(90.32%)died from 2 to 13 months after diagnosis although primary tumor was not found.Conclusions The headache and dizziness are the main symptom.The immunocytochemistry are important in the diagnosis of the meningeal carcinoma.The prognosis of the cases with meningeal carcinoma is serious whatever found or not found primary cancer.

Objective To study the changes of left ventricular structure and function after transcatheter closure of atrial septal defect(ASD)by strain rate(SR)imaging.Methods Twenty-eight patients with secundum type ASD were undergone transcatheter closure.Left and right ventricular end-diastolic diameter(LVED and RVED),left ventricular ejection fraction(LVEF),the Doppler transmitral filling velocities(E values and A values)and tricuspid regurgitation pressure were measured respectively at pre-operation,3 days,1 month and 3 months of post-operation.According to tricuspid regurgitation pressure,systolic pulmonary artery pressure(SPAP)was estimated.SR curves in all segments of left ventricular walls were acquired for all patients.The SR values including the peak of systolic SR,early-diastolic SR,late-diastolic SR were measured respectively.ResultsAfter operation,LVED,LVEF,E values and A values increased significantly while RVED and SPAP decreased.Almost all left ventricular walls' SR increased at post-operation except that SR of interventricular septeum(IVS)and left ventricular post wall(LVPW)decreased at 3 days,1 month of post-operation.Conclusions LV systolic and diastolic function are improved after operation,but SR characteristic changes of IVS and LVPW is the one of the most unique characters.