Objective To prepare ?-CD(?-cyclodextrin) inclusion compounds and PEG- 4000[poly-(ethylene glycol) 4000] solid dispersions of mefenamic acid (MFA)in order to improve its dissolution. Methods The inclusion compounds of MFA were prepared using saturated ?-CD solution method by orthogonal test. The solid dispersions were prepared using melt-cool process with PEG- 4000 as a carrier. The inclusion compounds and solid dispersions were identified by differential scanning calorimetry (DSC) gram and their dissolution rates were tested in pH8.0 buffer solution. Results The suitable condition for preparing ?-CD inclusion compounds of MFA industrially was the weight ratio of 1∶4 between MFA and ?-CD, agitating for 4 h at 70 ℃. The suitable proportion for preparing solid dispersions of MFA was the weight ratio of 1∶4 between MFA and PEG- 4000. Conclusion Dissolution rates of MFA are apparently improved in inclusion compounds and PEG- 4000 solid dispersions, and the solubility of MFA is apparently increased by 2～3 times in inclusion compounds and PEG- 4000 solid dispersions.

Objective To improve understanding of molybdenum target mammographic findings of hydatid cyst of the breast.Methods The data of mammographic findings of 7 cases with hydatid cysts confirmed by operation and pathology were collected and analyzed retrospectively. The related literatures were reviewed.Results Among 7 cases of hydatial cysts, multiple cyst in one, singular cyst in 6, one of them was rupture caused by trauma. Mammography showed a circluar or elliptical dense shadow, the density was homogeneous with well defined margen, measured 4～8 cm in maximum diameter, 3 cases appeared typical shell-like calcification.Conclusion In combination with clinical and endemical data, molybdenum target mammography can be used in diagnosing hydatid cyst of the breast.

Objective To compare the effectiveness of propafenone,(intravenous and oral) and lanatoside C in reversing atrial fibrillation (AF) and their safety in non-rheumatic patients.Methods Ninety-seven recent onset(≥0 5h～41days) AF patients were included. Subjects with valvular heart disease, heart failure (NYHA heart function≥Ⅲ degree),myocardial infarction, sick sinus syndrome, atrioventricular block(≥Ⅱ degree), preexcitation syndrome and hyperthyroidism were excluded. Three groups were subdivided according to the results:⑴ The group of intravenous propafenone(groupⅠ):thirty-three patients were given intravenous injection propafenone 70 mg within 7 minutes, the non-converted patients were given another 140 mg (0 5～1mg/min) intravenous infusion. ⑵The group of oral loading dose propafenone: Thirty-two patients were given propafenone 450 mg orally(groupⅡ).⑶The group of intravenous lanatoside C(groupⅢ):Thirty-two patients were given intravenous lanatoside C 0 4 mg within five minutes and another 0 2 mg must be added to if AF was not reversed in 4 hours. EKG, blood pressure, symptoms, AF reversing and ventricular rate were closely observed under heart monitoring all patients. The time from intravenous injection or receiving the drug to reversing the AF to sinus rhythm was recorded. Observing the reversal rate and time of the three groups of patients for 30 minutes,1h, 2h, 4h, 8h respectively, we could get the results as follows.Results Average reversal time is: group Ⅰ (0 8?0 4)h, group Ⅱ(4 1?1 8)h. group Ⅲ(3 7?2 0)h, There was a prominent difference (P0 05).Conclusion Of the above three methods in reversing AF, the average reversal time of intravenous propafenone is the shortest, and the have the most efficient reversal rate.

Objective To study the appropriate antibiotic for prophylactic use in cesarean section. Methods The effects and side effects of prophylatic antibiotics in 1 266 cesarean section were studied retrospectively. Six regiems were engaged: (1) Penicillin and Ampicillin; (2) Mezlocillin sodium; (3) Sulbactam and Ampicillin; (4) Ciprofloxacin; (5) Clindamycin; (6) Cefacidal. Results The duration of postoperative body temperature return to normal of 1-6 group is (54.0?28.4) hours, (48.9?27.8) hours, (49.9?23.9) hours, (58.6?33.7) hours, (52.5?25.2) hours, (63.1?51.1) hours respectively. It was longer in cefazolin group than the others. There were less puerperal morbidity and side effects of Mezlocillin. Conclusions Penicillin and Ampicillin are still the most common choices as prophylatic antibiotic in cesarean section. Mezlocillin is appropriate as well.

Objective To investigate the clinical efficacy of new-type patent endotracheal tube in difficult endotrachea intubation patients.Methods Seventy-three patients with the abnormal airways were selected as our subjects.Patients were given the traditional endotracheal tube by mouth after anesthesia.The successes patients in terms of endotracheal intubation were as group Ⅰ (n =73).The failed patients were asgroup Ⅱ (n =63),who performed the secondary endotracheal intubation with new type patent endotracheal tube.Analyze the success rate of intubation of the two groups when on use the tube core.Results The first time intubation success rate and intubation success rate was (2.7％ (2/73),13.7％ (10/73) respectively) in Ⅰ group,and 73.02％ (46/63) and 98.41％ (62/63) respectively in the group Ⅱ,and there was the significant difference between two groups (x2 =36.01,31.08 respectively,P ＜ 0.01).Conclusion The new type endotracheal tube was proved with three advamage of good plasticity,without need of auxiliary core intubation with trachealtube and give full play to lead the soft cannula guide tubes leading role.Therefore,the new type patent endotracheal tube has more efficacy over traditional tube.

Objective To study the pathogenesis, the diagnoses and the pre-hospital emergency treatment of comatose patients. Methods 314 comatose patients admitted to our hospital from September 2003 to September 2004 were analyzed retrospectively and followed in the hospital. Results Among 314 comatose patients, 119 had cerebrovascular accidents, 91 with poisoning, 42 with metabolic diseases, 37 cardiovascular diseases and 25 others. After pre-hospital treatment, 68 patients were recovered, 199 with stable conditions, 31 deterioated and 16 died. Conclusion Among the comatose patients, cerebral diseases and poisoning accounted for the most. The pre-hospital treatment could improve the successful rate of rescue.

Objective To observe the effect of extract of Coprinus comatus on small intestinal propulsion and gastric emptying function in mice.Methods Effect of extract of Coprinus comatus at different doses on small intestinal propulsion and gastric emptying function was observed in normal mice,neostigmine-load mice and epinephrine-load mice by charcoal powder method and by modified phenol red method respectively.Results The small intestinal propulsion of normal mice was promoted by the extract of Coprinus comatus at the doses of 3.0,6.0,9.0 and 12.0 g/kg,and the gastric emptying function of normal mice was promoted by the extract of Coprinus comatus at the doses of 1.5,3.0,6.0,9.0 and 12.0 g/kg,the difference being significant as compared with the normal group (P

To study the current situation of Chinese medicine services from both perspective of supply and demand, looking to promote the healthy development of Chinese medicine community health service strategy. Questionnaire survey was conducted to practitioners of 14 community health service centers in Longhua district (80) and service objects (800). Ratios and SWOT methods were used for analysis. 75 qualified practitioners and 736 qualified service objects questionnaire recoveries showed that there are different degrees of commands from both sides, different options on therapeutic methods and lack of practitioners. It is suggested that community health service center should supply TCM service according to different time, different place and different patient on different type and levels.

Objective To investigate the expression of apolipoprotein M in rats after renal transplantation and its role and action mechanism in acute rejection (AR).Methods The kidney transplantation model in rats were established.Male SD and Wistar rats were used as donors,and Wistar rats as recipients.Three groups were designated:control group (syngeneic transplantation,n =24,recipients were treated with normal saline i.p.); AR group (allogeneic transplantation,n =24,recipients were treated with normal saline i.p.); PDTC group [allogeneic transplantation,n =24,recipients were treated with NF-κB inhibitor-pyrrolidine dithiocarbamat (PDTC) i.p.].The renal grafts were drawn at day 1,3,5 and 7 post-transplantation,and the expression levels of NF-κB P65 and apoM protein were detected by using Western blotting,and those of apoM,perforin and granzyme B mRNA were by using real-time PCR.The correlation of apoM and NF-κB,apoM and perforin,and apoM and granzyme B was respectively analyzed.Results As compared with control group,the expression levels of apoM,perforin and granzyme B mRNA in AR and PDTC groups were dramatically up-regulated at each time point (P＜0.01),and those in PDTC group were significantly lower than those in AR group (P＜0.01).The expression levels of apoM and NF-κB protein in AR group were both distinctly higher than those in control group (P＜0.01),and those in PDTC group were markedly lower than those in AR group (P＜0.01).A significantly positive correlation was found between the expression of apoM and NF-κB protein (r =0.469,P＜0.05).And the expression of apoM mRNA was positively correlated to perforin and granzyme B mRNA (r =0.731,P＜0.01 ; r =0.514,P＜0.05).Conclusion The expression of apoM is obviously up-regulated in renal grafts of rats,which may take part in the pathogenesis of AR via NF-κB.

Objective To investigate the application of parametric quantification (PQ) with targeted microbubbles on angiogenesis after stem cell transplantation in rabbits with myocardial infarction.Methods A CD34-targeted microbubble was prepared.Acute myocardial infarction (AMI) model were established by ligating coronary artery in 80 New Zealand white rabbits.Rabbits in common microbubble group (T + C group) and CD34-targeted microbubble group (T + T group) were subjected to myocardial contrast echocardiography(MCE),then compare myocardial perfusion parameters (A,β and A × β values) pre- and 3d post- ligation and 4 weeks after stem cell transplantation.Microvessel density (MVD) were determine by CD34 antibody immunohistochemistry.Results Compared to before stem cell transplantation,the perfusion scores ( P ＜0.05) and A,β and A× β values( P ＜0.01) of T+ C group and T+ T group were increased than before transplantation and control group.MVDs after stem cell transplantation in experimental groups were higher than those of control group ( P ＜0.01),especially the T + T group.A × β value in the T + C group was correlated with MVD ( r =0.658,P ＜ 0.05) ; β and A × β value in the T + T group were correlated with MVD ( r =0.620,0.859,P ＜0.05).A × β value ( X ) and MVD ( Y ) were included to establish the following regression equation:Y =- 130.986 + 34.505 X ( R 2 =0.556,P ＜ 0.05).Conclusions PQ and CD34-targeted microbubble probably provides some value in invasive evaluation of angiogenesis after stem cell transplantation.