Autoimmune pancreatitis is a special type of chronic pancreatitis that can lead to abnormal pancreatic exocrine function in patients. Autoimmune pancreatitis comorbid with pancreatic exocrine insufficiency has a complex pathogenesis， and there is limited research on this topic， leading to the lack of understanding of such patients in clinical practice. This article introduces the epidemiology of autoimmune pancreatitis， briefly describes the pathogenesis of pancreatic exocrine insufficiency caused by autoimmune pancreatitis， and summarizes the various detection methods for pancreatic exocrine function， nutritional assessments， lifestyle management， and drug therapy， in order to strengthen the understanding of autoimmune pancreatitis comorbid with pancreatic exocrine insufficiency and improve the clinical diagnosis and treatment of pancreatic exocrine insufficiency.

Irritable bowel syndrome (IBS) is an extremely common chronic intestinal disorder characterized by recurrent abdominal pain and altered bowel habits, significantly impacting patients' quality of life. The etiology of IBS remains incompletely understood. Research has identified low-grade intestinal inflammation and immune activation, primarily manifested as an imbalance between pro-inflammatory and anti-inflammatory cytokines, as key pathogenic mechanisms in IBS. Among these, interleukin-6 (IL-6), a core pro-inflammatory cytokine, is significantly elevated in IBS patients. IL-6 contributes to the pathogenesis of IBS through various mechanisms, including altering individual susceptibility to IBS, promoting gastrointestinal motility and secretion, activating the hypothalamic-pituitary-adrenal axis, inducing visceral hypersensitivity, and impairing intestinal mucosal barrier function. Furthermore, IL-6 levels are closely associated with the severity of IBS symptoms. This review summarizes the role and mechanisms of IL-6 in IBS, aiming to provide insights and references for clinicians and researchers investigating the etiology of IBS.

Intravitreal injection of anti-vascular endothelial growth factor(VEGF)agents has become the primary treatment for macular edema associated with retinal vascular disease such as diabetic retinopathy and retinal vein occlusion, but there are limitations such as variable treatment efficacy and insufficient durability of therapeutic effects. As the first bispecific antibody applied in ophthalmic treatment, Faricimab achieves favorable outcomes by simultaneously targeting both VEGF-A and angiopoietin-2(Ang-2)pathways. Based on evidence from recent clinical trials and real-world studies, this article reviews the research progress on Faricimab for the treatment of diabetic macular edema(DME), retinal vein occlusion-associated macular edema(RVO-ME)and refractory macular edema compared to the therapeutic effects of other agents. Additionally, based on Faricimab's safety characteristics and future potential, its therapeutic prospects for macular edema associated with retinal vascular diseases are discussed. This review aims to provide evidence-based references for optimizing clinical treatment strategies, thereby contributing to mitigating the risk of vision loss due to macular edema.

To promote the standardization and normalization of perioperative care for follicular unit extraction(FUE) hair transplantation, ensure treatment efficacy, and align with advancements in the specialty, the Nursing Branch of the Chinese Association of Plastic and Aesthetics organized a panel of domestic experts. By integrating evidence-based medicine with clinical practice experience, and following thorough discussions, these experts developed the Clinical Practice Expert Consensus on Perioperative Nursing Care for Follicular Unit Extraction (2025). This consensus provides a comprehensive overview of hair transplantation, covering preoperative preparation, surgical procedures, intraoperative coordination, postoperative management, and complication prevention and treatment. It serves as a key reference and guide for implementing standardized perioperative nursing care in FUE hair transplantation.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.