Objective:To investigate the effects of sign-contract services on hypertension patient disease control and the satisfaction of medical staff. Methods:a face-to-face questionnaire survey was conducted among hypertension patients selected from 20 primary health centers in 10 provinces in China. Results:This paper collected 1 ,881 valid questionnaires, and the average age of the population was 65. 72 ± 10. 88. Respondents that received sign-contract services accounted for 53. 88%, and there was no difference between patients who signed the service contract and who did not in terms of demographics. In self-reporting of blood pressure controls, respondents who signed the service contract, aged 40~50 years old, enjoyed the free medical care, preferred to seek medical services from primary a-gencies ( i. e. community health centers and township hospitals) for minor illnesses, controlled their blood pressure better ( P<0. 05 ) . Respondents enjoyed the civil resident medical insurance, preferred to seek medical care from community health centers for minor illnesses and signed the service contract were more likely to be satisfied with their medical practitioner (P<0. 05). After adjusting for age, gender, education level, medical insurance style, patient willingness to seek medical care for minor illnesses, signing service contracts was found to be an independent factor both associated with blood pressure self-control and attitudes towards medical service providers, with the odds ratio of 3. 007 (95%CI:2. 572 -3. 517) and 1. 814 (95%CI: 1. 563 -2. 105) respectively. Conclusion: Contracts are correlated with blood pressure control and satisfaction toward medical practitioners, which means that patients who signed the service contract control their blood pressure better and are more satisfied with their medical deliverers.

Objective To understand the status of service contract signing conducted by primary medical and health institutions.Methods A questionnaire survey and in-depth interview methods were used to study the service contract signing at primary health care institutions.Results The contract signing rate of the institutions surveyed was 1 9.1%,and valid contract signing rate was 76%.Senior people above 65 years old accounted for 33.5% of those signers,while hypertension patients accounted for 1 9.5% and diabetes patients for 10.6%.Interviews to the general practitioners team at the primary health institutions found that main factors affecting residents′ intention to sign were drug availability, attraction for signing the services,treatment habits among others.Interviews to the staff the primary health institutions found that contracted services are facing such difficulties as medical staff shortage,lack of motivation,lack of competence among others.Interviews to leaders of the primary health institutions found that the lack of publicity and support of medical insurance also has great influence to service contract signing.Conclusions The enthusiasm of general practitioners and residents to sign up for the service remains to be improved.

Objective To discuss the effects of community diabetes specialist nurse training practice from the perspective of knowledge management, in order to provide some references for personnel training mode of the community nurses. Methods We established community diabetes specialist nurse training practices, screened 80 community nurses to participate in training, and implemented the training practices. The training objects were surveyed with the diabetes knowledge and performed duties questionnaires before and after the training. Diabetes knowledge level and the degree of willingness to perform duties were as evaluation indexes, SPSS 18. 0 software was used for analyzing and processing the date, and studying training effects from the perspective of knowledge management. Results Diabetes knowledge test accuracy of community nurses were 37. 0%, 68. 4% before and after the training (Z=7. 36, P<0. 01);willingness to perform their duties showed that options of very willing were 52. 5%(42/80), and options of willing were 46. 2%(37/80), and only one person said reluctantly willing. Conclusions The training practice can guarantee quality of nursing knowledge resources which were imported community health service centers, promote effectively spread, flow and use of knowledge resources in the community health service centers, then to promote knowledge utilization value.

Objective Discussion the effect on the diabetes knowledge level of community nurses and the patients satisfaction after applied the mode of “integration and sharing” to the training of community diabetes care.Methods A total of 30 community health service centers were randomly divided into two groups in accordance with the principle of voluntariness .15 communities were distributed to the experimental group and constructed the mode of “integration and sharing”, and the other 15 communities were distributed to the control group adopted the conventional method for diabetic training .The diabetes knowledge level of the two groups and the satisfaction of patients with diabetes in those communities were investigated before the intervention .One year later, the two groups were re-investigated using the same questionnaire .Results One year later , the scores of diabetes knowledge of the experimental group increased significantly from (29.29 ±5.91) to (35.22 ±4.91), while the scores of the control group increased from (29.39 ±6.33) to (30.94 ±6.33).There were significant differences between the two groups after intervention (Z=10.896, 3.226, 8.650, respectively; P<0.01). One year after the intervention , the score of satisfaction of the experimental group and the control group were (4.50 ±0.67) and (4.28 ±0.66), respectively.There was statistically significant between the two groups (t=2.758, P<0.01).Conclusions The mode of “integration and sharing” can improve the level of diabetes knowledge of community nurses , and the satisfaction rate of diabetic patients .It also can help to enhance the quality of diabetes care in community .

A series of farnesylthiosalicylamide derivatives(9a-9k)were designed and synthesized via condensating the carboxyl of farnesylthiosalicylic acid(FTS)with different amines, and the in vitro biological activity was evaluated. It was observed that eight of them displayed strong antitumor activity against five human cancer cells in vitro. Notably, compound 9k exhibited the most active with the IC50 values of 6. 05-8. 16 μmol/L range against the tested cancer cells, which were superior to those of FTS and even comparable to that of sorafenib in vitro. In addition, compound 9k down-regulated the protein of Bcl-2 and increased the expression levels of Bax and caspase-3 proteins, indicating that compound 9k could induce tumor cell apoptosis.