It is inevitably that any medical laboratory instrument may have trouble during its operation no matter how advanced it is.The only difference is the failure rate of each medical laboratory instrument.So in order to ensure these instruments work normally,it is very important to maintain them correctly.This paper gives an introduction of characteristics and maintenance requirements about medical laboratory instruments.

Objective To identify the spatial distribution of stray radiation from mobile CT head scanning for the purpose of radiation protection.Methods The head series of CareTom mobile CT were scanned and the radiation dose was measured using TLD (LiF:Mg,Cu,P).The isodose maps of radiation dose field were plotted using Matlab software.Results Radiation dose in the front of the mobile CT was slightly higher than that in the back.The maximum value of 0.255 mGy was found to be at 0.5 m from the scanning hole center.Conclusions The stray radiation dose from mobile CT head scanning was relatively low.However in order to avoid the damage to the operators and other medical workers from long-term low dose exposure,it should keep 2 m away from mobile CT,beside or behind,when in operation.

Objective To investigate the feasibility and clinical value of anteroposterior and lateral scout scan combined with Care Dose 4D and Care kV in chest CT scan.Methods A total of 60 patients of clinical diagnosis with lung tumor were enrolled.Those patients were randomly divided into test group and control group.Control group underwent a scan protocol with lateral scout scan combined with Care Dose 4D and Care kV,while anteroposterior and lateral scout scan combined with Care Dose 4D and Care kV were performed in test group.The signal-to-noise ration (SNR),contrast-to-noise ratio (CNR),and overall image quality of two groups of images and diseased tissues were analyzed and evaluated by two high-grade radiologists using double-blind method.Effective doses (E) were also calculated.Results All the 60 patients had successfully completed the chest CT scans.Test group overall image quality (4.57 ± 0.45) and control group overall image quality (4.73 ± 0.45) had no statistically significant difference (P ＞ 0.05).The control group image SNR,CNR and diseased tissue SNR,CNR compared with test group had no statistical significance difference (P ＞ 0.05).The difference of the volume CT dose index (CTDIvol),dose-length product (DLP) and effective dose (E) of test group and control group was statistically significant (t =8.514,8.464,8.464,P ＜ 0.001).Compared with control group,the effective dose of test group decreased by 33.3％.Conclusions Compared with lateral scout scan,the technology of anteroposterior and lateral scout scan combined with Care Dose 4D and Care kV can decrease radiation dose without reducing the image quality.This technology can therefore be considered as a regular imaging modality for chest CT scan.

Objective: To understand the cardiopulmonary endurance status of Tibetan middle school students in different high altitude areas and the relationship with body mass index (BMI), and to provide reference for cardiopulmonary endurance improvement among students in different high altitude areas. Methods: From October to November 2019, 3 819 Tibetan middle school students in Linzhi, Lhasa, and Nagqu Regions of Tibet were tested with the 1 000meter run for boys and 800 meter run for girls, and BMI was calculated. The cardiorespiratory endurance of middle school students in different high altitude areas was compared, the detection rate of wasting, normal, overweight and obesity was compared with the χ 2 test, and the relationship between body mass index and cardiorespiratory endurance was analyzed by multiple linear stepwise regression. Results: The differences in VO 2max between Tibetan middle school students aged 13-15 and 17-18 years in Nyingchi, Lhasa and Nagqu were statistically significant( F=26.72, 13.75, 23.86, 8.68, 9.35, P <0.01), and 13-14, 16-18 years old girls in three regions with VO 2max ( F=5.29, 4.36, 11.38 , 7.79, 16.30，P <0.01). The proportion of boys wasting in Linzhi area was 10.2%, that of Lhasa area was 8.7%, and that of Nagqu area was 17.5%, the difference was statistically significant( χ 2=25.91, P <0.01); the proportion of girls wasting, Linzhi, Lhasa, and Nagqu were 2.6%, 2.5%, 5.1%, the difference was also statistically significant( χ 2= 8.35 , P <0.05). Multiple linear stepwise regression analysis showed that after body mass index and altitude included, the model △ R 2=0.075, and Tibetan middle school students were overweight and obese ( B=0.44, 95%CI =0.39-0.49) and positively correlated with VO 2max ( P <0.01); weight loss ( B=-0.36, 95%CI =-0.42--0.29) was negatively correlated with VO 2max ( P <0.01); altitude [Lhasa Area： B(95% CI )= -0.44(-0.49--0.39)，Nagqu Region： B(95%CI )=-0.51(-0.56--0.45)] was negatively correlated with VO 2max ( P <0.01). Conclusion Overweight and obesity are positively correlated with VO 2max , and weight loss and altitude are negatively correlated with VO 2max . The proportion of wasting among Tibetan middle school students in high altitude areas needs to be focused for cardiorespiratory endurance improvement.

OBJECTIVETo investigate the chemical constituents of the extract of Galium verum.

METHODThe compounds were isolated by chromatography and identified by spectral data.

RESULTThe eleven compounds obtained were identified as (+)-pinoresinol 4,4'-O-bis-beta-D-glucopyranoside (1), epipinoresinol (2), (+) -medioresinol (3), isorhamnetin (4), isorhamnetin 3-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranoside (5), diosmetin (6), diosmetin 7-O-beta-D-glucopyranoside (7), quercetin-3-O-beta-D-glucopyranoside (8), ursolic acid (9), ursolic aldehyde (10) and rubifolic acid (11).

CONCLUSIONCompounds 1-5 and 9-11 were isolated from this genus for the first time.

Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Galium ; chemistry

OBJECTIVETo investigate the effects of the solid-state fermentation technology in extracting the ingredients of traditional Chinese medicine (TCM).

METHODUsing Danggui Kushen pills as an example, four index ingredients of ferulic acid, matrine, matrine alkaloids and dry extract were compared comprehensively, and the difference between the two water extractions of fermented pills and unfermented pills was evalued.

RESULTThe comprehensive evaluated result was that extraction of fermented pills was better than that unfermented.

CONCLUSIONThe solid-state fermentation is conducive to the extraction of prescription of Danggui Kushen pills.

Chemical Fractionation ; methods ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; metabolism ; Fermentation ; Reproducibility of Results ; Water ; chemistry

Objective:To explore the improvement of image quality of different acceleration factors in breath-hold three-dimensional magnetic resonance cholangiopancreatography (3D MRCP) using deep learning (DL) and compressed sensing (CS) technology.Methods:A total of 68 patients who underwent upper abdominal 3D MRCP examination at West China Hospital of Sichuan University from March to August 2023 were prospectively included. The patients were subdivided into three groups randomly with the following paramters: CS group with an acceleration factor of 24 (CS-24); DL-CS group with acceleration factors 24 (DL-CS-24) and 33 (DL-CS-33) respectively. The signal-to-noise ratio (SNR), contrast ratio (CR) and contrast-to-noise ratio (CNR) of the three sets of images were measured, and the overall image quality, background suppression, artifacts, and visibility of bile ducts and pancreatic ducts at all levels were subjectively evaluated. Chi-square test and Friedman test were used to perform statistical analysis on the number of unsatisfactory diagnostic images and subjective and objective indicators of the three groups of sequences respectively.Results:The scanning time of the DL-CS-33 group (9 s) was 30% shorter than that of the CS-24 group and DL-CS-24 group (13s). The images of DL-CS-33 group from 68 patients all met the clinical diagnostic requirements and statistically differences were found between the images from CS-24 group and DL-CS-24 group (all P<0.05). There were no statistically differences in SNR, CR, CNR, overall image quality, artifacts, and visibility scores of bile ducts and pancreatic ducts at all levels between the DL-CS-33 group and the CS-24 group (all P>0.05). The SNR, CR, CNR, intrahepatic bile duct, main pancreatic duct and overall image quality of the DL-CS -24 group were better than those of the CS-24 group (all P<0.05). Conclusions:DL-CS technology could improves breath-hold 3D MRCP image quality with the 24 acceleration factor with no additioanl scanning time. DL-CS technology combined with a high acceleration factor of 33 further reduces scanning time while ensuring overall image quality, providing a fast breath-hold scanning solution.

Objective To evaluate the therapeutic effect with peter-williams intramedullary nail on children with humerus deformity due to osteogenesis imperfecta.Methods Data of 9 patients with humerus deformity due to osteogenesis imperfecta were retrospectively analyzed from Jun.2009 to Dec.2012.There were 7 males and 2 females,aged from 6 years to 10 years and 7 months(average 8 years and 3 months).There were 7 unilateral humerus deformity and 2 bilateral humerus deformity with severe radius and ulna deformity.The humerus fracture frequency was from 4 to 13 times (average,7.9 times)There were 2-3 deformity points in 9 patients (average 2.09 deformity points).The deformity angle ranged from 20°-100° (average 57.3°).The Constant-Murley scores were 16-24 scores (average 20.44).According to revised Sillence classifications,there were 6 cases of Type Ⅲ and 3 cases of Type Ⅳ.Eleven humerus of 9 patients were osteotomied and fixed with peter-williams intramedullary nail.Results All of 9 children were followed up for 12-66 months(average 22 months).The bone healing time were 8-12 weeks (average 9.5 weeks).Parents of 9 children were satisfied with surgical operation effect and deformity correction.The Constant-Murley scores ranged from preoperative average of (20.44 ± 2.79) points (16-24 points) to postoperative average of (35.56 ± 2.60) points(30-38 points) at the latest follow-up of patients,there was a statistically significant in score before and after treatment(t =0.20,P ＜0.05).Number 4 patient,one patient was found suffering from dorsal thumb numbness postoperatively after 3 days back stretching limitation.Considering the radial nerve stretching injury,treatment with neurotrophic drug for 3 months,symptoms disappeared.There was no infection,or osteomyelitis,no vascular damages.Epiphyseal plate injury or premature closure and affecting growth were not found in all of the patients at the latest follow-up examination.Conclusions Treatment with osteotomy and peter-williams intramedullary nail fixation on children with humerus deformity due to osteogenesis imperfecta is advantaged.It gets less damages,no intruding shoulder joint,less bleeding.The greatest degree of correction of the deformity can be achieved,and the shoulder joint function and the quality of life can be improved.

With the developing technique of the diagnosis and treatment of early gastric cancer, the quality of early gastric cancer diagnosis and treatment is coming into focus, and is crucial to improve the overall management of gastric cancer. It is necessary to establish a quality control system to ensure the quality of diagnosis and treatment for EGC. Based on the summary of the diagnosis and treatment status and technological progress of early gastric cancer, this paper proposes the quality control strategy, content and plan for the diagnosis and treatment process of EGC from the aspects of multidisciplinary diagnosis and treatment, clinical diagnosis technology, endoscopic and surgical treatment, pathological diagnosis and follow-up, with a view to expound the rationality, standardization and quality guarantee of the diagnosis and treatment process for early gastric cancer.

With the developing technique of the diagnosis and treatment of early gastric cancer, the quality of early gastric cancer diagnosis and treatment is coming into focus, and is crucial to improve the overall management of gastric cancer. It is necessary to establish a quality control system to ensure the quality of diagnosis and treatment for EGC. Based on the summary of the diagnosis and treatment status and technological progress of early gastric cancer, this paper proposes the quality control strategy, content and plan for the diagnosis and treatment process of EGC from the aspects of multidisciplinary diagnosis and treatment, clinical diagnosis technology, endoscopic and surgical treatment, pathological diagnosis and follow-up, with a view to expound the rationality, standardization and quality guarantee of the diagnosis and treatment process for early gastric cancer.