We experienced three cases of non-giant congenital nevus. They showed zosteriform or heart-shaped grouping of pigmented papules which were pierced by hairs. Histopathologic examination disclosed nevus cell infiltration in and around hair follicles and in the upper two thirds of reticular dermis. We would like to report these cases as follicle-centered spotted grouped pigmented nevi.
Dermis ; Hair ; Hair Follicle ; Nevus ; Nevus, Pigmented*

We present herein a case of sebaceous hyperplasia in a 55-year-old male, who showed multiple asymptomatic yellowish papules on the forehead and the cheeks. Histopathologic examination of a papule revealed numerous sebaceous lobules grouped around several enlarged sebaceous ducts. Three weeks of oral administration. of isotretinoin 40 mg per day brought marked improvement.
Administration, Oral ; Cheek ; Forehead ; Humans ; Hyperplasia* ; Isotretinoin* ; Male ; Middle Aged

PURPOSE: To evaluate high signal intensity of nontumorous conditions of corpus callosum on T2-weighted MR images. MATERIALS AND METHODS: Fourty nine patients with nontumorous high signal intensities involving corpus callosum on sagittal T2-weighted image were restrospectively analyzed. Nontumorous condition of corpus callosum were diffuse axonal injury(DAI, 19 cases), cerebral infarctions(16 cases), multiple sclerosis(MS, 5 cases), Wilson's disease(2 cases) and hydrocephalus(7 cases) that were diagnosed by clinical and MR findings. Numbers, configuration, involved thickness and sites of high signal intensities of corpus callosum were analyzed. RESULTS: DAI and infarctions showed either single or multiple lesions. MS and hydrocephalus showed multiple lesions, but Wilson's diseases showed single lesion. In DAI, infarctions and MS the lesions involved any part of corpus callosum, splenium in WIIson's disease, and all parts of corpus callosum in hydrocephalus. Wilson's disease showed only partial thickness involvement, and others involved partial or full thickness of corpus callosum. Configuration of high signal intensity was linear in most cases of hydrocephalus, and oval in Wilson's disease, and oval and confluent in MS, and variable in DAI and infarctions. CONCLUSION: High signal intensities of nontumorous conditions of corpus callosum revealed variable findings, and therefore, analysis of nontumorous high signal intensities of corpus callosum is not made by only MR findings but by conjuction with clinical aspects.
Axons ; Corpus Callosum* ; Hepatolenticular Degeneration ; Humans ; Hydrocephalus ; Infarction

No abstract available.

PURPOSE: In clinically suspected ankylosing spondylitis of sacroiliac (SIJ) and hip joints with normal or minimal secondary bone change in simple X-ray films, we evaluated the role of MRI in sacroiliac and hip joints. MATERIALS AND METHODS: Authors evaluated 11 cases (36 joints;SIJ 14, hip 22) confirmed as spondylitis by clinical, laboratory, and radiologic findings, and compared the detectability of involvement of joints by simple X-ray film and MRI. Authors analysed MR findings for the presence of pannus and its si, intensities (SI), change of articular cartilage, bony erosion and sclerosis, subchondral bone cysts,.~ osteophytosis, bone marrow edema, joint effusion, adjacent soft tissue change, and contrast enhancement ofi pannus. RESULTS: MRI detected not only 20 joints (SIJ 11, hip 9) detected in simple X-ray, but also additional 7 joints (SIJ 3, hip 4). MRI depicted simultaneous involvement of SIJ and hip joints in 5 of 11 cases (SIJ 10 joints, hip9 joints), and bilateral involvement of SIJ and hip joints in 4 among the 5 cases. MRI also demonstrated pannus, which were not detected in conventional films, as intermediate SI on T1WI and high SI on T2WI, in all 27 joints (SIJ 14, Hip 13). Gd-DTPA enhanced T1WI revealed enhancement of pannus in 7 cases (17 joints). CONCLUSION: MRI was a valuable modality in evaluation of clinically suspected ankylosing spondylitis of SIJ or hip joints with normal or minimal secondary bone change in simple X-ray. Simultaneous evaluation of SIJ and hip joints is suggested in clinically suspected ankylosing spondylitis or other joint diseases.
Bone Marrow ; Cartilage, Articular ; Edema ; Gadolinium DTPA ; Hip Joint* ; Hip* ; Joint Diseases ; Joints ; Magnetic Resonance Imaging ; Sclerosis ; Spondylitis ; Spondylitis, Ankylosing* ; X-Ray Film

No abstract available.
Amniotic Fluid* ; Female ; Humans*

Objective To investigate the onset of left ventricular remodeling (LVRM) after acute myocardium infarction (AMI) and its changes within 6 hours in dogs on echocardiography. Methods AMI was induced in 14 dogs by ligating the left anterior descending arteries. Eight myocardium infarcted models were successful and were sacrified for pathological study. The indices of LVRM: wall infarction thickness (WIT), the wall motion score index (WMSI), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF) were evaluated before and 1 h, 2 h, 3 h, 4 h, 5 h and 6 h after operation. Results Compared with the pre-operation, WIT and LVEF were decreased (P<0.01), LVESV and WMSI were increased (P<0.01), and LVEDV was increased (P<0.05 or P<0.01) at every time point after operation. WIT had no significant difference at 1 h, 2 h, 3 h, 4 h, 5h and 6h after operation (P＞0.05). LVEDV, LVESV were higher (P<0.05) and LVEF was lower (P<0.05 or P<0.01) at 4 h, 5 h, and 6 h than at 1 h, and 2 h after operation. WMSI was higher at 3 h, 4 h, 5 h, and 6 h than at 1h (P<0.05). Conclusions In our experiment, LVRM occurred at 1 h after AMI in dogs. Thus echocardiography may evaluate early LVRM.

Focal cerebral ischemia was made in 20 adult cats by transorbital middle cerebral artery occlusion (MCAO) under pentobarbital anesthesia. Arterial blood gas, systemic arterial blood pressure (SABP), intracranial pressure (ICP), and regional cerebral blood flow (rCBF) on ectosylvian, suprasylvian, and marginal gyrus of the left hemisphere by hydrogen clearance were measured for 30 minutes before and 120 minutes after middle cerebral artery occlusion. Ten animals were treated with 20 mg/kg of pentoxifylline (PTF) and ten animals with 1ml/kg of normal saline as the control group for 30 minutes before and 30 minutes after middle cerebral artery occlusion. There was no beneficial effect of pentoxifylline (Trental(R)) on basal blood flow over left hemisphere before middle cerebral artery occlusion. Regional cerebral blood flow was highly significantly improved on the marginal gyrus (MG) for 90 minutes after middle cerebral artery occlusion, more remarkable for initial 60 minutes (P<0.01), and also significantly restored on suprasylvian gyrus (SSG) for initial 60 minutes by pentoxifylline (P<0.05). However, pentoxifylline failed to improve regional cerebral flow on extosylvian gyrus (ESG) which was considered dense core of infarct area due to middle cerebral artery occlusion in cat. In addition, pentoxifylline had significant hypotensive effect during intravenous administration for 60 minutes (P<0.05). These findings suggest the possibility of pentoxifylline to ameliorate hemorheological property rather than vasodilating effect in the collaterally perfused area around dense infarct.
Administration, Intravenous ; Adult ; Anesthesia ; Animals ; Arterial Pressure ; Brain Ischemia ; Cats ; Cerebral Infarction* ; Hemorheology ; Humans ; Hydrogen ; Infarction, Middle Cerebral Artery ; Intracranial Pressure ; Pentobarbital ; Pentoxifylline*

No abstract available.
Epidermolysis Bullosa ; Muscular Dystrophy, Duchenne ; Ornithine Carbamoyltransferase ; Polymerase Chain Reaction* ; Preimplantation Diagnosis*

Excessive activation of the N-methy-D-aspartate(NMDA) subtype of glutamate receptor, has been implicated in the sequence of neurochemical events which results in irreversible neuronal damage in cerebral ischemia. The effect of the NMDA antagonist upon the amount of ischemic brain damage has been already assessed by some investigators. But most of them were performed only in acute ischemic models. In the light of clinical experiences, it's neuroprotective effect is much more important in the prolonged ischemic model. So, authors produced the permanent occlusion of the left middle cerebral artery(MCAO) and sacrificed the animals 48 hours after the occlusion to observe the neuroprotective effect of the NMDA antagonist, MK-801, in the maturated condition of ischemia according to the previous PART I experiment. MK-801 was administered 2 times, intravenously 1 hours prior to MCA occlusion(0.5 mg/kg) and intraperitoneally 1 hour after the induction of ischemia(5 mg/kg) to maintain proper concentration of the drug. CBF was measured by hydrogen clearance methods. Areas of brain infarction were delineated by tetrazolium salt at the preselected 8 coronal levels of forebrain and measured on scale diagrams by a plannimeter. MK-801 had no effect on the cardiopulmonary function. In the control, the basal value of CBF was around 118 ml/100 g/min. Immediately after MCAO, CBF of the ipsilateral cortex was reduced to 13.3+/-2.6 ml/100 g/min and not recovered until the end of the experiment. But CBF of the contralateral cortex was maintained in the basal value throughout the experiment. In the treated, immediately after the intravenous administration of the drug. CBF of both frontal cortices was reduced to 15 to 20% of the basal value(P<0.001), and the reduced CBF was noted even after MCAO, comparing to the control, but 24 hours later the reduced CBF of the contralateral cortex recovered to the basal value. Treatment with MK-801 reduced the total amount of ischemic damage in the cerebral hemisphere(15.82+/-2.41 versus 10.66+/-1.33 cm, P<0.001) and the cerebral cortex(11.0+/-3.73 versus 6.30+/-1.6 cm, P<0.001). But the effect on the caudate nucleus was minimal. This experiment provides evidence for the potency of the glutamate antagonist, MK-801, in reducing ischemic brain damage, despite the result was obtained 48hours after MCAO. And the anti-ischemic effect of MK-801 in the experiment could not be attributed to by improvement of blood flow to the hypoperfused cerebral tissue.
Administration, Intravenous ; Animals ; Brain ; Brain Infarction ; Brain Ischemia ; Caudate Nucleus ; Dizocilpine Maleate* ; Glutamic Acid ; Humans ; Hydrogen ; Infarction, Middle Cerebral Artery* ; Ischemia ; Middle Cerebral Artery* ; N-Methylaspartate* ; Neurons ; Neuroprotective Agents ; Prosencephalon ; Rats* ; Receptors, Glutamate ; Research Personnel