3.Correlation between PAK1 gene polymorphism and prognosis of endocrine therapy for breast cancer
ke-ji, ZHANG ; ying-chun, XU ; feng-chun, ZHANG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(09):-
Objective To investigate the correlation between p21-actived kinase 1(PAK1) gene polymorphism and prognosis of endocrine therapy for breast cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism was employed to analyze the genotype of PAK1 gene rs2298793 T→C polymorphism and rs2844327 C→T polymorphism of 105 patients with breast cancer accepting endocrine therapy. Prognostic factors such as age, state of menses, magnitude of tumor, pathological type, condition of operation, clinical stage, estrogen receptor, progesteron receptor, Her-2 and endocrine therapy drug were comprehensively considered, and Cox model was employed to analyze the relation of PAK1 genotype with the time-to-tumor progression (TTP). Results As to rs2298793C→T polymorphism, the TTP of CT genotype was shorter than TT genotype (P
4.Differences on the parameters of the optic disc between the amblyopic eye and non-amblyopic eye in adolescent with anisometropic amblyopia
Wei, ZHANG ; Chun-Ling, HU ; Chun, SHI ; Ji-Ping, CAI
International Eye Science 2016;16(7):1336-1340
AIM: To compare the peripapillary retinal nerve fiber layer ( RNFL ) thickness and peripapillary topographic map's parameters between amblyopic eyes and non -amblyopic eyes in adolescent with anisometropic amblyopia by optical coherence tomography(OCT).
METHODS: Thirty - four juveniles with anisometropic amblyopia were selected. Peripapillary RNFL thickness and peripapillary topographic map were measured by frequency domain OCT with both eyes in all participants, and the differences between amblyopic eyes and non -amblyopic eyes were compared.
RESULTS: There was no significant difference in average thickness of peripapillary RNFL and in any other region of peripapillary RNFL. The disc area in amblyopic eyes was bigger than that in non - amblyopic eyes ( t =2. 8054,P= 0. 0263). The disc area in amblyopic eyes were significantly related to the thickness of nasal RNFL and the rim area(r= 0. 7592,0. 7501;P= 0. 0289,0. 0321).
CONCLUSION: There existed some difference in peripapillary structure between amblyopic eyes and non-amblyopic eyes in adolescent with anisometropic amblyopia.
5.A case of anticardiolipin syndrome with a leg ulcer on the lower extremities.
Korean Journal of Dermatology 1991;29(6):874-879
No abstract available.
Leg Ulcer*
;
Leg*
;
Lower Extremity*
8.Gladness and troubles for using garlic as an anti-oxidant.
Chinese Journal of Integrated Traditional and Western Medicine 2004;24(5):462-463
Allyl Compounds
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chemistry
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pharmacology
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toxicity
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Animals
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Antioxidants
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chemistry
;
pharmacology
;
toxicity
;
Drugs, Chinese Herbal
;
chemistry
;
pharmacology
;
toxicity
;
Garlic
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chemistry
;
toxicity
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Humans
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Phytotherapy
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adverse effects
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Sulfides
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chemistry
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pharmacology
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toxicity
9.Baicalein induced Nrf2 activation and its protection against hepatotoxicity
Chun PANG ; Ping JIANG ; Lili JI
Chinese Pharmacological Bulletin 2014;(4):546-549
Aim To study the activation of Nrf2 in-duced by baicalein ( BAI ) , and its protection against carbon tetrachloride ( CCl4 ) , ethanol and acetamino-phen ( APAP )-induced hepatotoxicity. Methods A reporter gene assay was conducted in human normal liver L-02 cells to detect the activation of transcription factor Nrf2 induced by baicalein. APAP ( 10 mmol · L-1 ) , CCl4 (10 mmol·L-1 ) and Ethanol (100 mmol · L-1 ) were used to induce hepatotoxicity in L-02 cells. After the pre-incubation with Baicalein (0, 1, 10, 25, 50, 100 μmol·L-1 ) for 15 min, cells were administrated with or without those above hepatotoxins. 48 h later, cell viability was detected by 3-(4, 5-dim-ethylthiazol-2-yl ) 2 , 5-diphenyltetrazolium bromide (MTT) method. Results Baicalein (25, 50 μmol· L-1 ) induced the activation of Nrf2 ( P <0. 01 , P <0. 05) in the reporter gene assay. As compared with control, three hepatotoxins ( APAP, CCl4 , Ethanol ) all decreased cell viability ( P<0. 01 ) , and baicalein significantly reversed such decreases in a concentra-tion-dependent manner ( P<0. 01 ) . Conclusion Ba-icalein can induce the activation of transcription factor Nrf2 , which is probably one of the mechanisms con-tributing to the protection of baicalein against hepato-toxins (APAP, CCl4, Ethanol)-induced hepatotoxici-ty.
10.Industrial low back pain in shipyard workers.
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(2):259-268
No abstract available.
Low Back Pain*