2.Progress and Insight of miRNA on Hepatocellular Carcinoma
Peng QI ; Chun-Fang GAO ;
China Biotechnology 2006;0(12):-
MicroRNAs(miRNAs) are endogenous non-coding RNAs,about 20 nucleotides in length.They play a pivotal role in the regulation of genes involved in diverse biology processes such as cell development,proliferation,differentiation and apoptosis by the translation repression or mRNA degradation.Recent evidence has suggested that miRNA alterations are involved in the initiation and progression of various human cancer including hepatocellular carcinoma(HCC),and miRNA-expression profiling of HCC has identified signatures associated with diagnosis,staging,progression and prognosis.As a novel molecular target,miRNAs holds great promise in diagnosis and biotherapy of HCC.
3.Circulating RNA and miRNA in Blood:Potential Applications as Tumor Markers
Peng QI ; Chun-Fang GAO ;
China Biotechnology 2006;0(11):-
Circulating nucleic acids (CNAs) are extracellular nucleic acids found in cell-free serum,plasma and other body fluids from healthy subjects as well as in patients. The ability to detect and quantitate specific DNA and RNA sequences has opened up the possibility of diagnosis and monitoring of diseases,especially in the field of cancer. Furthermore,in some recent studies it has been suggested a kind of non-coding RNA-microRNA (miRNA),also exist in cell-free serum and plasma,highlighting the field of using CNAs to diagnose cancer. As a novel tumor marker,tumor-specific circulating miRNAs holds great promise in early diagnosis of cancer.
5.Clinical significance of tumor markers for diagnosis of hepatoceilular carcinoma
Lu WANG ; Chun-Fang GAO ;
Academic Journal of Second Military Medical University 1999;0(12):-
Hepatocellular carcinoma(HCC),one of the most common malignant tumors,is the main cause of cancer death in China.Early diagnosis of the disease is of great importance.Serum tumor markers have been effective for detecting HCC for a long time.Among those markers,alpha fetoprotein(AFP)is the most widely used one in detecting patients with HCC,but it has limited utility for detecting HCC due to its limited sensitivity and specificity.Searching better markers for HCC has been a re- search focus in recent years.This review introduces many useful markers to supplement AFP for detecting HCC.
7.Surveillance on endemic situation of schistosomiasis of Mianzhu City after 5·12 earthquake
Chun HE ; Jianyun SHI ; Jiong GAO
Chinese Journal of Schistosomiasis Control 2010;22(2):200-200
The surveillance of schistosomiasis in three sites of Mianzhu City after earthquake showed that there were no infected Oncomelania snails and cases,but the emerging area with snails were 7 895 m~2.Therefore,the control measures should be strengthened.
8.Analysis on development advantages of health food with Chinese medical feature
Lili QIAN ; Xuemin GAO ; Chun WANG
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(06):-
Along with the rising of Chinese medicine consumption,health food with Chinese medical feature plays an increasingly role in people's life,and its market shares increase every year.This article analyzes the advantages from aspects of literature,theory,function,security,resources and market of health food,in order to develop health food and inherit the theory of Chinese medicine.
9.Protection Effects of Different Dosage of Reduced Glutathione on Liver Function in Acute Myeloid Leukemia Patients Undergoing Chemotherapy
Kaibo GAO ; Yong TONG ; Chun FENG
China Pharmacy 2005;0(24):-
OBJECTIVE:To discuss the protection effects of different dosage of reduced glutathione on liver function in acute myeloid leukemia(AML) patients undergoing chemotherapy.METHODS:In prospective study,72 AML patients were divided into group A and group B according to the dosage of reduced glutathione.Reduced glutathione were given to group A(1.2 g?d-1) and group B(2.4 g?d-1) 2 days before chemotherapy.Liver functions of patients were rechecked 1 week after chemotherapy.Another 2 weeks of treatment was given to patients with liver function disorder.RESULTS:1 week or 2 weeks after chemotherapy the incidence of liver function impairment in group B was decreased significantly,compared with group A(P
10.Expression and clinical significance of RNA-binding protein Musashi1 in colorectal cancer
Boyue DING ; Chun HAN ; Chao GAO
Journal of International Oncology 2016;43(3):226-228
Musashi1 (Msi1) is an evolutionary conservative RNA-binding protein (RBP),and it is a stem marker in a variety of organizations,including intestinal,neural system.Msi1 maintains the balance between self-renewal and differentiation.Recently,many researchers report that Msi1 is overexpressed in many types of tumors,especially in colorectal neoplasms,participating in the regulation of cell cycle,proliferation,apoptosis and so on.Msi1 becomes a key regulator of many cancers,which is expected to turn into a new target for cancer therapy.