OBJECTIVE:To study the pharmacokinetics and relative bioavailability of two kinds of cefaclor capsule in healthy volunteersMETHODS:Plasma cefaclor concentrations were measured with HPLC methodEach subject was administered with a single oral dose of domestic or imported cefaclor capsule(500mg)in a randomized crossover studyRESULTS:Plasma concentration-time curves of domestic and imported cefaclor capsules fitted to a one-compartment open model with a first order absorptionThe peak plasma levels(Cmax)averaged(1324?242)and (1329?314)?g/ml,times to reach the peak level(Tmax)were (058?0192)and(055?010)h,the elimination half lives(T1/2)were (042?009)and(041?009)h,the areas under the plasma concentration-time curve(AUC0～T)were (1581?153)and(1568?197)h/(?g?ml)respectivelyCONCLUSION:The results of statistical analysis showed that the two formulations were bioequivalentThe relative bioavailability of domestic capsule was(10084?778)%

No abstract available.

No abstract available.

Objective To survey the application of diagnosis and implementation of treatment guidelines of cerebrovascular disease( CAD)combined community acquired pneumonia( CAP)in the community of Shenyang. Methods Randomly chose 7 hospitals in different levels in districts and counties of Shenyang,and made a retrospective survey on the treatments of CAD combined CAP from Oct. 2009 to Jun. 2012 to clear the implementation. Meanwhile,the collected cases were divided into in compliance with guidelines group and non compliance with guidelines group. The information including clinical stable time,length of hospital stay,efficient treatment,empiric therapy and prognosis with the help of guidelines were collected. Results Four hundred and eighty-eight cases were qualified from collected 532 cases,in which,38. 5% initial diagnosis and treatment was accord with the guidelines formulated by the Respiratory Branch of Chinese Medical Association. The efficiency of initial empirical treatment was 84. 5%. The clinical stable time in compliance with guidelines group was (5. 00 ± 0. 27)d,better than that in non compliance with guidelines group((8. 00 ± 0. 45)d;P=0. 021). The length of hospital stay was(11. 00 ± 0. 25)d in compliance with guidelines group,significantly less than that in non compliance with guidelines group(( 14. 00 ± 0. 53 ) d;P =0. 015 ). The effective rate of patients with respiratory failure in compliance with guidelines group was 90. 9%,higher than non compliance with guidelines group(58. 6%),and the difference was significant(P=0. 026),while there were no significant differences in terms of gender,heart and lung diseases. Conclusion There is the smaller patient proportion that diagnosed and cured in accordance with the guidelines formulated by the Respiratory Branch of Chinese Medical Association. It is no distinctive difference for the efficient treatment of guidelines. But selected antibiotic application according to the guidelines can improve the clinical stable time and hospital stay of CAD combined CAP,as well as reduce invalid cases and reduce the mortality rate. The guidelines need to be further extended.

OBJECTIVE:To study the counteraction of melatonin(MT)on the oxidative damage model of brain tissues of mice caused by glutamic acid.METHODS:The mice were randomly divided into blank group,model group and melatonin(MT)(high dosage and low dosage)group.Drugs were injected(by intraperitoneal injection)into the mice of the MT group in advance for7days.Each group were injected with glutamic acid through lateral ventricle to form models,levels of MDA and GSH and the activity of GSH-PX of each group were determined.RESULTS:There was a significant increase in the level of MDA(P

The effect of intravesical formalin instillation as a therapeutic modality for intractable bladder hemorrhage in well known. And despite clear evidence of therapeutic efficacy of intravesical cytotoxic drugs and / or BCG immunotherapy, there have been substantial recurrences during follow up after transurethral resection for superficial bladder tumor. If formalin injected at the bed of superficial bladder tumor is able to coagulate and necrotize the tumor, it will be greatly helpful to the patients with recurrent bladder tumor developed during follow up. Since this technique is applicable on outpatient basis, an economical as well as a psychological burden of the patients can be reduced considerably. The purpose of this study is to evaluate the effect of submucosal formalin injection on rat bladder wall. 36 healthy adult male Sprague-Dawley rats (weighing 350 gm in average) were divided into 3 groups: In Group I (control group), 0.01ml of normal saline was injected submucosally at the left posterolateral wall of the bladder opened under intraperitoneal Nembutal anesthesia; In Group II and III, 0.01 ml of 10% and 4% formalin, respectively, were administered at the same site as in the Group I, two rats in each group were sacrificed at day 1, 2, and 3, and week 1, 2, and 4 after injection, respectively. Gross and microscopic examination of the cystectomized specimen were done in each group. In the Group II, bladder stones were formed at week 1, and in both the Group I and III, stones were seen at week 2 post injection. There was no significant difference in histologic findings of the bladder between the group II and III. Mucosal ulcer and/or prominent mucosal disruption was observed at 24 hours after injection in both Group II and III. Epithelial regeneration began at day 2, and was marked at day 3, and epithelial lining was almost normalized one week after injection. Subepithelial edema, telangiectasia and inflammatory reaction were prominent at 24 hours post formalin injection. Subepithelial edema persisted in moderate degree for 1 week. Telangiectasia and inflammatory reaction were noted for 4 weeks. Mild degree of these findings also appeared in the control group. Fibroblastic proliferation appeared at day 2 and persisted in moderate degree for 4 weeks. There has been no mortality or bladder perforation. These results suggest that clinical application of this technique is feasible for the selected cases of recurrent, solitary superficial bladder tumor. However, optimal dosage of formalin in relation to the size of the lesion remains to be investigated.
Adult ; Anesthesia ; Animals ; Edema ; Fibroblasts ; Follow-Up Studies ; Formaldehyde* ; Hemorrhage ; Humans ; Immunotherapy ; Male ; Mortality ; Mycobacterium bovis ; Outpatients ; Pentobarbital ; Rats* ; Rats, Sprague-Dawley ; Recurrence ; Regeneration ; Telangiectasis ; Ulcer ; Urinary Bladder Calculi ; Urinary Bladder Neoplasms ; Urinary Bladder*

No abstract available.
Interleukin-2* ; Interleukins* ; Mucocutaneous Lymph Node Syndrome* ; Receptors, Interleukin-2*

Objective To investigate the effect of surgical intervention combined with steroid therapy on infantile hepatitis(INS) with persistent jaundice.Methods Twenty-two patients (19 males,3 females,aged 2-6 months) with persistent jaundice(therapy group) were admitted into hospital in the period of Jan.2007-Dec.2008.The patients were performed with surgical intervention after they were confirmed with diagnosis as INS.Then,sodium chloride,gentamicin and Dexamethasone were used to irrigate the biliary tract during and after the operation for 14 days.Three days after operation,20 mg,15 mg,10 mg,5 mg of methylprednisolone were administered intravenously to the patients every 3 days,followed with 4 mg/(kg?d) prednisone by oral for 2-3 months.The 17 cases of INS with persistent jaundice were treated with medicine as control(control group).By following-up,the jaundice free and 2 years survival rate of 2 groups were compared by counting the cases of jaundice free and recording the survival time.Results Two cases of 22 patients performed with surgical intervention were diagnosed as biliary atresia and others were INS,90.0% patients were free of jaundice in surgical intervention combined with steroid therapy group,which was higher than that in control group(52.9%,P

Objective To observe the anesthesia effect of dezocine and pentazocine in painless artificial abortion, in order to provide a basis for safe use of anesthesia drug in clinical practice. Methods Totally,300 patients undergoing painless artificial abortion were included in this study.The patients were randomly divided into four groups: group A (simple propofo), group B ( propofol combined with fentanyl) ,group C ( propofol combined with dezocine) and group D ( propofol combined with pentazocine)(n=75 each).Four groups of patients were intravenously injected with propofol (1-1.5 mg?kg-1) according to the situation in operation when necessary to maintain anesthesia effect.Heart rate (HR),mean arterial pressure (MAP),arterial oxygen saturation ( SpO2 ) and respiratory frequency were observed and recorded before induction,after induction,at the beginning of the operation,during operation and anesthesia recovery. The onset time of anesthesia, the recovery time, the recovery time of orientation,the postoperative pain score and the incidence of adverse reaction of the four groups were recorded. Results All of the patients achieved good effects of anesthesia in operations. There was no significant difference in the onset time of anesthesia (P>0.05).Awakening time and time of orientation recovery in groups B,C and D were significantly shorter than those in group A (P<0.05).The dosages of propofol in group C and D were significantly less than those in group A and B (P<0.05).The changes of HR,MAP,SpO2 and respiratory frequency after induction were not significantly different in group B,C and D (P>0.05),but the changes were relatively stable as compared with group A (P<0.05).The rates of adverse reactions in group B,C and D were significantly lower than that in group A (P<0.05).The incidence rates of respiratory depression,nausea and vomiting in group C and D were significantly lower than those in group A and B (P<0.05).The postoperative pain scores of VAS in group B,C and D were significantly lower than that of group A (P<0.05). Conclusion The analgesia effects of dezocine and pentazocine are similar.Application of them can reduce the dosage of propofol and shorten the anesthesia awakening time in painless artificial abortion,at the same time they have less adverse reactions,and they are safe and effective to be used in clinical anesthesia.

Objective To study the effect of Shenfu injection combined with low dose glucocorticoid on endothelial function and blood coagulation in elderly patients with severe pneumonia. Methods 120 patients with severe pneumonia in our hospital from January 2014 to January 2017 were selected,and randomly divided into treatment group and control group,60 cases in each groups.. All patients were treated with conventional treatment. On this basis, the control group was treated with small dose of glucocorticoid. The treatment group was treated with Shenfu Injection on the basis of the control group. The severity, endothelial function and coagulation function of the two groups were compared at different times after treatment. Results The scores of APACHE and 120 h in the two groups were significantly lower than those in the control group (P<0.05). The score of the treatment group was lower (P<0.05) than that of the control group (96 h). After treatment, the two groups of patients with s E-selectin, V WF, APTT, D-D were significantly decreased, PLT significantly increased, significant difference (P<0.05); compared with the control group, s E-selectin, V WF, APTT, D-D and other indicators of the treatment group decreased and PLT increased even more sharply, there is statistical significance (P<0.05). Conclusion Shenfu injection combined with small dose of glucocorticoid therapy, can alleviate the function and coagulation function in patients with endothelial damage, relieve endothelial dysfunction, improve coagulation status of patients, and has higher application value.