Objective To construct and evaluate the effect of WeChat platform self-management program among colorectal cancer survivors with ostomies. Methods Totally 80 colorectal cancer survivors with ostomies were divided into two groups according the inclusive time with 40 cases each. The patients in the experimental group were applied WeChat platform self-management program, the control group were applied regular discharge telephone follow-up. The patients′ self-efficacy and quality of life were measured and compared prior to discharge, at 1 and 6 weeks after discharge. And the patients' occurrence of stoma complications were measured at 1 and 6 weeks after discharge. Results Due to quit research, finally complete the study of the experimental group for 36 cases, the control group for 35 cases. The total score of self-efficacy at 1 and 6 weeks after discharge were (72.05± 9.68), (84.91±16.01) points in the experimental group, and (63.00 ± 13.26), (72.20 ± 15.61) points in the control group, and there were statistically significant differences (t=-2.586, 3.388, P<0.01). The total score of quality of life at 1 and 6 weeks after discharge were (43.68±8.32), (49.49±8.61) points in the experimental group, and were (37.09± 5.57), (40.42 ± 8.01) points in the control group, and there were statistically significant differences (t=3.926, 4.596, P<0.05). Repeated measures analysis of variance showed that the intervention effect on the overall self-efficacy, stoma care self-efficacy, social self-efficacy and stoma quality of life was significant (F=4.287-10.744, P<0.05);the time effect on the overall self-efficacy and quality of life was significant (F=146.109, 90.105, P < 0.05); there were interactions between the effect of WeChat platform self-management program and time on the overall self-efficacy, stoma care self-efficacy, social self-efficacy, dietary efficacy, sexual life satisfaction efficacy, keep active efficacy and stoma quality of life ( F=4.452-21.777, P<0.05) . Chi-square analysis showed that the patients′occurrence of stoma complications at 1 and 6 weeks after discharge in the experimental group were lower than those in the control group:8.33%(3/36), 5.56%(2/36) and 31.43%(11/35), 25.71%(9/35), the differences were significant (χ2=5.980, 5.508, P < 0.05). Conclusions WeChat platform self-management program may be helpful for colorectal cancer survivors with ostomies after discharge in improving self-efficacy and quality of life, and in reducing stoma complications incidence.