The protective effects of Nifedipine, Aspirin and Aspirin combined with Nifedipine on acute myocardial ischemia induced by pi-tuitrin in rats were studied, when 20% Alcohol (2ml/kg), Nifedipine (0.05 mg/kg) and Aspirin (0.025mg/kg) was singly used, no remakable effects were observed on the indexes of ischemic ECG of the experimental rats. When Nifedipine (0.1mg/kg) or Aspirin (0.05mg/kg) was used singly, or they were used in combination (0.05 + 0.025mg/kg ); The significant counteractions were observed on the changes in ST segments and T waves in the first and second phases of the rats ECG caused by pituitrin, and the occurrence of decrease of heart rate and arrhythmia were prevented. The doses were correlated with the effects. The two drugs used in combination showed noticeable synergism.