Objective To evaluate the safety and efficacy of domestic biodegradable drug-eluting stent, EXCEL, in clinical treatment of coronary heart disease.Methods During the period of Jan.2008-Oct.2008, 100 patients with coronary heart disease who consented to PCI and postoperative coronary angiography were selected and enrolled in the study.The patients were divided into EXCEL group(n = 58) and Cypher group(n = 42).The immediate successful rate of interventional therapy and the complications occurred during hospitalization were observed.Postoperative follow-up and checkup coronary angiography were conducted.Results No significant difference in the relevant clinical data, in the number and type of diseased coronary branch and in the mean length of implanted stents existed between two groups.Also, no statistically significant difference in the occurrence of major adverse cardiac event(MACE), in-stent restenosis and thrombosis was present between two groups.Conclusion Compared with Cypher stenting, EXCEL stenting carries similar, i.e.rather low, occurrence of MACE and in-stent restenosis.