0.05),the incidence of adverse drug reactions were 3.5% and 2.4%,respectively and the total treatment costs were(4 146.45?282.15)yuan and(4 807.20?318.15)yuan,respectively;and the cost-minimization analysis showed that manicol was the preferred therapy as compared with Glycerol Fructose.In the treatment of the patients with cerebral infarction complicating renal dysfunction,the total effective rates of the two drugs were 80.0% and 93.3%,respectively(P

OBJECTIVE:To observe the clinical efficacy of Tanreqing injection in the treatment of children's viral pneumonia.METHODS:A total of sixty children with viral pneumonia were randomly divided into 2 groups:the treatment group(n=30)were treated with Tanreqing injection(20mL)plus Glucose(250mL)qd for 7d while the control group(n=30)with Cibavirin(10～15mg?kg-1)plus Glucose(250mL)bid for 7d.The primary outcome measures were clinical efficacy and adverse drug effects(ADRs).RESULTS:The effective rate was 100% in the treatment group as compared with 80% in the control group,showing significant differences between the two groups(P

OBJECTIVE:To evaluate the cost-effectiveness of Tanreqing injection in treating children's viral pneumonia.METHODS:In this retrospective study,sixty children with viral pneumonia were randomly assigned to receive Tanreqing Injection(treatment Group,n=30)or Ribavirin(control Group,n=30).The clinical effects and adverse drug reactions(ADRs)of the two groups were compared,and the cost-effectiveness analyses were performed.RESULTS:The effective rate was 100% in the treatment Group versus 80% in the control Group;the incidence rate of ADRs was 3.33% vs.13.33%;the cost was 297.88 vs.399.95 yuan;and the cost-effectiveness was 297.88 vs.499.94,all showing significant differences between the two groups(P

Objective To explore the effect of femtosecond laser-assisted in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE)femtosecond laser in the treatment of myopic astigmatism with thin cornea.Methods From September 2022 to September 2023,128 pa-tients with thin cornea myopic astigmatism in the hospital were selected and randomly divided into FS-LASIK group(64 cases,128 eyes,receiving FS-LASIK)and SMILE group(64 cases,124 eyes,receiving SMILE).The visual acuity[uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA)]before surgery and at 1 year after surgery,refractive parameter spherical equivalent(SE)at 3,6 and 12 months after surgery,corneal surface morphology[average corneal curvature(KAve),surface regularity index(SRI),surface asymmetry index(SAI)]before surgery and at 1 year after surgery,corneal biomechanic indicators[corneal expansion comprehensive deviation analysis index(BAD-D),corneal biomechanical index(CBI),total biomechanical index(TBI)]and corneal injury degree[corneal endothelial cell count,corneal endothelial cell size,coefficient of variation(C V)]and differences in postoperative astigmatism correction vector indicators[magnitude of error(ME),angle of error(AE),correction index(CI),and index of success(IOS)]were compared.Residual stromal bed thickness and the incidence of complications after surgery were recorded.Results One year after surgery,both UCVA and BCVA in both groups were improved compared with preoperation(P＜0.05),but there were no significant between-group differences(P＞0.05).At 3,6,and 12 months postoperatively,the SE levels in both groups were higher than preoperation(P＜0.05);however,there were no statistically significant differences in SE levels between the groups at above time points(P＞0.05).One year after surgery,KAve,SRI,and SAI in both groups were lower than preoperative levels,and the SMILE group was lower than those in the FS-LASIK group(P＜0.05).One year after operation,BAD-D and TBI in both groups were higher than preoperative levels,while CBI was lower than preoperative levels;however,BAD-D and TBI in the SMILE group were lower than those in the FS-LASIK group,and CBI was higher than that in the FS-LASIK group(P＜0.05).One year after surgery,corneal endothelial cell counts in both groups were lower than preop-erative levels,and CV of corneal endothelial cell size was higher than preoperative levels;however,corneal endothelial cell count in the SMILE group were higher than those in the FS-LASIK group,and the CV of corneal endothelial cell size was lower than that in the FS-LASIK group(P＜0.05).There were no statistically significant differences in ME,AE,CI,and IOS between the two groups(P＞0.05).The residual stromal bed thickness was(302.01±55.03)μm in the FS-LASIK group and(310.23±46.03)μm in the SMILE group after surgery,with no statistically significant be-tween-group difference(t=1.284,P=0.200).One year after surgery,there were 5 cases of dry eye in the FS-LASIK group and 2 cases in the SMILE group,with no statistically significant differ-ence in incidence of dry eye between the two groups(x2=1.227,P=0.268).Conclusion For patients with myopic astigmatism with thin cornea,both FS-LASIK and SMILE can achieve satisfac-tory improvement in visual acuity and refractive state,and the latter one has a relatively small impact on the integrity of corneal structure,biomechanical stability and surgical injury.

Objective To explore the effect of femtosecond laser-assisted in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE)femtosecond laser in the treatment of myopic astigmatism with thin cornea.Methods From September 2022 to September 2023,128 pa-tients with thin cornea myopic astigmatism in the hospital were selected and randomly divided into FS-LASIK group(64 cases,128 eyes,receiving FS-LASIK)and SMILE group(64 cases,124 eyes,receiving SMILE).The visual acuity[uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA)]before surgery and at 1 year after surgery,refractive parameter spherical equivalent(SE)at 3,6 and 12 months after surgery,corneal surface morphology[average corneal curvature(KAve),surface regularity index(SRI),surface asymmetry index(SAI)]before surgery and at 1 year after surgery,corneal biomechanic indicators[corneal expansion comprehensive deviation analysis index(BAD-D),corneal biomechanical index(CBI),total biomechanical index(TBI)]and corneal injury degree[corneal endothelial cell count,corneal endothelial cell size,coefficient of variation(C V)]and differences in postoperative astigmatism correction vector indicators[magnitude of error(ME),angle of error(AE),correction index(CI),and index of success(IOS)]were compared.Residual stromal bed thickness and the incidence of complications after surgery were recorded.Results One year after surgery,both UCVA and BCVA in both groups were improved compared with preoperation(P＜0.05),but there were no significant between-group differences(P＞0.05).At 3,6,and 12 months postoperatively,the SE levels in both groups were higher than preoperation(P＜0.05);however,there were no statistically significant differences in SE levels between the groups at above time points(P＞0.05).One year after surgery,KAve,SRI,and SAI in both groups were lower than preoperative levels,and the SMILE group was lower than those in the FS-LASIK group(P＜0.05).One year after operation,BAD-D and TBI in both groups were higher than preoperative levels,while CBI was lower than preoperative levels;however,BAD-D and TBI in the SMILE group were lower than those in the FS-LASIK group,and CBI was higher than that in the FS-LASIK group(P＜0.05).One year after surgery,corneal endothelial cell counts in both groups were lower than preop-erative levels,and CV of corneal endothelial cell size was higher than preoperative levels;however,corneal endothelial cell count in the SMILE group were higher than those in the FS-LASIK group,and the CV of corneal endothelial cell size was lower than that in the FS-LASIK group(P＜0.05).There were no statistically significant differences in ME,AE,CI,and IOS between the two groups(P＞0.05).The residual stromal bed thickness was(302.01±55.03)μm in the FS-LASIK group and(310.23±46.03)μm in the SMILE group after surgery,with no statistically significant be-tween-group difference(t=1.284,P=0.200).One year after surgery,there were 5 cases of dry eye in the FS-LASIK group and 2 cases in the SMILE group,with no statistically significant differ-ence in incidence of dry eye between the two groups(x2=1.227,P=0.268).Conclusion For patients with myopic astigmatism with thin cornea,both FS-LASIK and SMILE can achieve satisfac-tory improvement in visual acuity and refractive state,and the latter one has a relatively small impact on the integrity of corneal structure,biomechanical stability and surgical injury.