1.Expression of Plasma Soluble HLA-G and Factors Involving Influencing its Expression Levels in Patients with Systemic Lupus Erythematosus
Fengxia WU ; Lijun WU ; Xiongyan LUO ; Minghui YANG ; Ningtao LIU ; Banjiang KUER ; Chuangmei XIE ; Xiaoyun SONG ; Zhong TANG ; Guoyuan ZHANG ; Jingguo ZHOU ; Yan ZHAO ; Xiaofeng ZENG ; Guohua YUAN
Journal of Medical Research 2006;0(03):-
0.05).However,the patients with increased levels of sHLA-G had higher incidence of central nervous system involvement(P=0.007) and more severe disease activity(P=0.027) in comparison with patients with normal plasma sHLA-G levels.Finally,the expression of plasma sHLA-G was not influenced by the treatment with glucocorticoids,immunosuppressive agents or antimalarials.Conclusion The increased production of sHLA-G indicates that sHLA-G may play an important role in the pathogenesis of SLE.The expression of sHLA-G may be associated with disease activity and severity of lupus patients,but be independence of HLA-G 14bp ins/del polymorphism and drug treatment.
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