Objective To study the relationship between serum fibrosis parameters levels and chronic viral hepatitis B patients.Methods Radioimmunoassay and chemiluminescence were used to test the levels of hyaluronic acid(HA),collagen type Ⅳ(Ⅳ-C),laminin(LN) and procollagen type Ⅲ(PC Ⅲ) in 146 cases of chronic hepatitis B and 40 of normal controls,and the relationship with clinical parameters of liver function were analyzed.Results The levels of HA,Ⅳ-C,LN,PC Ⅲ in chronic hepatitis B patients were higher than those of normal control group (P ＜0.05 or P ＜ 0.01),there were statistical differen in different course of disease (P ＜ 0.05 or P ＜ 0.01) ; The levels of serum Ⅳ-C and PCⅢ had positive correlation with plasma PT,the same to HA with TBil and PCⅢ with ALT;The levels of HA,Ⅳ-C and LN had negative correlation with Alb,the same to LN with CHE.Conclusion The levels of HA,Ⅳ-C,LN and PC Ⅲ in chronic hepatitis B patients may reflect the situations of hepatic fibrosis and the degrees of liver function damage.

Objective To explore the clinical significance of blood serum AFP determination in gravis type viral hepatitis. Methods The level of blood serum AFP was determined by radioimmunoassay in 85 eases of gravis type viral hepatitis, and its change was observed in a dynamic state. Results The abnormality rate of AFP was 83. 6% in the patients of gravis type viral hepatitis. The abnormality rate of AFP in acute gravis type viral hepatitis was significantly lower than that in suhacute severe hepatitis and chronic severe hepatitis(P < 0.01). The survival rate in the team with high level of AFP was significantly higher than that of teams with normal or low level of AFP(P <0.01～0.05) in the patients of gravis type viral hepatitis. The blood serum AFP level in the survivors was significant-ly higher than that of the death in the patients of gravis type viral hepatitis(P <0.01). Conclusions The blood ser-um AFP determination in gravis type viral hepatitis,can be used as a sensitive index for prognosis. A high level of AFP indicates that the hepatic cells regeneration is active and the prognosis is relatively better.