Anaemia of chronic disease (ACD) is caused due to an underlying chronic inflammatory process. It is not due to marrow deficiency of iron. Chronic periodontitis is a chronic inflammatory condition which has been associated with anaemia of chronic disease. The aim of this study is to estimate various hematologic parameters suggestive of ACD in patients with chronic periodontitis and in the process to establish a relation between the two. Forty patients were selected and were categorized, based on the presence and absence of chronic periodontitis, into case and control groups, with 20 subjects in each group. Hematologic evaluation was done. Complete haemogram, haematocrit, erythrocyte sedimentation rate (ESR) and estimation of serum ferritin were done. An independent t-test was calculated. Statistically significant values (p<0.05) were obtained for neutrophil count, ESR, red blood cells (RBC), mean corpuscular haemoglobin concentration (MCHC) and serum ferritin. ESR, RBC and serum ferritin levels were significantly increased in subjects with chronic periodontitis. There were significant differences in neutrophil, ESR, RBC and serum ferritin in subjects having severe form of generalized chronic periodontitis. Thus, it was concluded that chronic generalized periodontitis, by means of an inflammatory process, influences various hematologic parameters are suggestive of anaemia of chronic disease.
Chronic Periodontitis ; Periodontitis

Chronic periodontitis (CP) is an inflammatory disease of the supporting tissues of the teeth caused by specific microorganism. Hypertension is one of the major causes of cardiovascular disease whereas periodontitis has recently drawn increasing attention because of its potential relationship with cardiovascular disease. The objectives of this study were to determine the prevalence of the hypertension in CP patients as well as to evaluate the association between hypertension and severity of CP. One hundred and eighty five records of CP patients treated in Dental Clinic, Universiti Sains Malaysia Hospital (USM Hospital), Kelantan from 2010 until 2013 were retrieved and reviewed. The diagnosis of periodontal disease and the presence of hypertension were recorded. The severity of chronic periodontitis was classified into mild, moderate and severe according to the clinical attachment loss. The data was obtained and analyzed using SPSS version 20.0. Majority of the subjects were from Malay ethnic group (94.4%) at the age range between 41 and 61 years (67.8%). In conclusion, the prevalence of hypertension in chronic periodontitis patients was 12.2%. There was no significant association between hypertension and severity of CP (p=0.229).
Hypertension ; Periodontitis ; Chronic Periodontitis

No abstract available.
Adult* ; Chronic Periodontitis* ; Humans

No abstract available.
Adult* ; Chronic Periodontitis* ; Humans

No abstract available.
Adult* ; Chronic Periodontitis* ; Doxycycline* ; Humans

OBJECTIVE: To explore the mechanism of smoking that promotes chronic periodontitis from the perspective of gingival microcirculation. METHODS: In experiment one, upper anterior teeth (n=102) from smokers with chronic periodontitis (Group A), nonsmokers with chronic periodontitis (Group B), and nonsmokers with healthy periodontal conditions (Group C) were selected to undergo gingival blood flow (GBF) through laser doppler flowmetry. In experiment two, the tissues obtained from gums during periodontal flap surgery were divided into smoking (Group A') and nonsmoking (Group B') groups, and the gingival tissue obtained from periodontal healthy nonsmokers treated with crown lengthening surgery or impacted wisdom tooth extraction served as the control group (Group C'). The microvessels density (MVD) of the gingival tissue from the three groups was determined in the tissue sections. SPSS 22.0 was used for statistical analysis. RESULTS: Compared with group C, GBF of all teeth increased in group B, and there were significant differences among 12, 21 and 23 teeth. MVD significantly differed between Group B' and C' (P<0.05), but they did not significantly differ between Group A' and B'. CONCLUSIONS Periodontitis can increase GBF and MVD, but smoking does not cause significant changes. However, the mechanism by which smoking promotes the occurrence and development of chronic periodontitis by influencing gingival microcirculation has not been discussed in this research.
Chronic Periodontitis ; Humans ; Microcirculation ; Smoking

OBJECTIVETo investigate the effect of serum biochemistry on the development of periodontitis.

METHODS225 participants without any system disease were involved in the study. Case group consist of 145 chronic peri-odontitis and was divided into gentle group (clinical attachment loss < 3 mm), moderate and severe group(clinical attachment loss > or = 3 mm). Control group consist of 80 periodontal healthy persons. Peripheral blood sample was obtained from each subject by venipuncture. Serum chemistry variables including glucose, lipid and calcium were analyzed. SPSS 12.0 software package was adopted to analyze the investigation results.

RESULTSThere's no statistically significant difference of serum, lipid and calcium between case group and control group (P > 0.05). But case group had a higher percentage of people with abnormal glucose, lipid and calcium than control group (P < 0.05). Moderate and severe group had a significantly higher serum glucose, triglyceride and lipoproteins-cholesterol than gentle group (P < 0.05).

CONCLUSIONAbnormal level of serum glucose, lipid and calcium may increase the affectability of host to periodontitis and promote the inflammation in paradentium.

The aim of the study was to see the total IgG and IgG subclass responses against Aa and Pg in the four early onset periodontitis (EOP) subforms or adult periodontitis (AP). 6 patients consisting of 3 patients from subform I (distinctive LJP pattern), 19 from subform II (post-juvenile periodontitis pattern), 16 from subform III ( LJP pattern but rapidly progressing), 24 from age-matched AP (20-40 years of age) have been selected for the measurements of the total IgG and each IgG subclass against to Pg and the IgG subclass against Aa, respectively. The total IgG titers against to Pg of the subforms I & III had a significantly higher values than subforms II and IV (P<0.05). Among the IgG subclasses, only the lgG3 levels were significantly higher in the subform I than the subform IV(P <0.05). Wide ranges of the antibody titers were noted in all of the EOP subforms and the AP. Except for the subform I, which was typical of localized form, the IgG2 subclass levels to Pg gradually became higher in accordance with the subforms II, III and IV. Both of IgG2 and the IgG4 antibody levels of the EOP were significantly higher than those of AP, while other subclasses were not. All of the four IgG subclass levels to Pg were consistently found to be higher in the younger age group around 20. The levels found to be low around the thirties and then gradually became higher at the ages of late thirties. The IgG2 titer to Aa in the subform I was significantly higher than those of any other subforms. Combinations of IgG1+2+4 were the most frequently found to be elevated followed by the IgG4 only, the IgG2 only, the IgG2+4, the IgG2+3+4, and the IgG1 only, in the descending order.
Aggregatibacter actinomycetemcomitans ; Aggressive Periodontitis* ; Chronic Periodontitis ; Humans ; Immunoglobulin G* ; Periodontitis ; Porphyromonas gingivalis

OBJECTIVEWe detected and analyzed the clinical values of total protein (TP), albumin (ALB), globulin (GLB), and ALB/GLB ratio (A/G) of whole unstimulated saliva of healthy people to determine the time of day when saliva composition is relatively stable. We compared the protein concentration and A/G of whole unstimulated saliva of patients with chronic periodontitis with those of healthy volunteers to provide references for diagnostic methods and clinical applications of saliva.

METHODSThe whole saliva of 37 healthy subjects were collected at 8:00, 9:30, 11:30, 13:00, 16:30, and 21:00. Meanwhile, the whole saliva of 24 patients with periodontitis was collected in the morning. Bicinchoninic acid method was used to detect the TP content. Saliva ALB was detected by GF-D800 semi-automatic biochemical analyzer, and the GLB and A/G were calculated. Finally, the results were statistically analyzed using SPSS 19.0.

RESULTSSalivary protein compositions were stable in the morning on an empty stomach. Healthy people: TP, (1 354.35±389.52) µg.mL-1; ALB, (139.55±27.19) µg.mL-1; GLB, (1 211.80±360.73) µg.mL-1; A/G, 0.126 3±0.041 7. Subjects with chronic periodontitis: TP, (2 611.56±231.62) µg.mL-1; ALB, (296.27±17.34) µg.mL-1; GLB, (2 315.69±221.67) µg.mL-1; A/G, 0.156 2±0.017 3. The contents of TP, ALB, and GLB in healthy individuals at different periods within a day showed significant differences (P<0.05), which were mainly reflected in the levels before and after meals. No significant difference was detected in A/G. The concentrations of TP, ALB, and GLB were significantly increased in patients with chronic periodontitis compared with those in healthy volunteers. However, no significant difference existed in A/G.

CONCLUSIONSalivary protein compositions are more stable in the morning than in other periods. Thus, mornings can be set as the time of specimen collection in future research. The concentrations of TP, ALB, and GLB in patients with chronic periodontitis are higher than those in healthy people.

ABSTRACT Erectile dysfunction (ED) and periodontitis have common risk factors, such as diabetes mellitus and tobacco smoking. Multiple reports are available in regard to the association between ED and chronic periodontitis (CP). The study aimed to determine the association of ED and CP in selected Malaysian population. In this study, 74 patients (mean age = 52.4 ± 10.9 years old) diagnosed with ED, from scores via the International Index of Erectile Function (IIEF-5) questionnaire, were included. ED severity was classified as mild, mild to moderate, moderate, and severe. Periodontal condition was recorded using basic periodontal examination (BPE) method, of which scores of 0, 1, 2, and 3 were associated with having no periodontitis while a score of 4 was considered to have periodontitis. There are 40 (54.1%) subjects found to have periodontitis and the association of ED and periodontitis showed a moderate positive degree of correlation, ρ = 0.487 (p < 0.001). The percentage of subjects having periodontitis indicated an increasing trend with the severity of ED; from 19.0% (mild ED), 54.2% (mild to moderate ED), 75.0% (moderate ED), to 84.6% (severe ED). A greater degree of correlation was noted between dental scaling experience and ED, ρ = 0.635 (p < 0.001). Binomial logistic regression had shown no other co-morbidities and factors were affecting this relation. There seemed to be an association between ED and periodontitis existing in these selected Malaysian populations.
Erectile Dysfunction ; Chronic Periodontitis ; Malaysia--ethnology