1.Pathology of Chronic Pancreatitis.
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2003;7(2):169-176
No abstract available.
Pancreatitis, Chronic*
;
Pathology*
3.Application of FISH technique for detection of fusion gene ABL/BCR in chronic myelogenous leukemia
Vinh Quang Pham ; Hoang Cong Tran ; Cuong Quoc Nguyen ; Hoa Khanh Bach
Journal of Medical Research 2007;51(4):35-40
Background: Detection of BCR/ABL fusion gene has important significance in diagnosing and monitoring response to therapy in chronic myeloid leukemia. Objective: Application of FISH (Fluorescence In Situ Hybrydization) technique for detection of abl/bcr fusion gene in chronic myelogenous leukemia. Subjects and methods: The study included 10 patients of chronic myelogenous leukemia diagnosed by methods of morphology and cell chemistry. Peripheral blood and bone marrow samples of them were analyzed Philadelphia (Ph1) chromosome by cytogenetic technique. Among them, 5 patients were tested by FISH technique on the slide of interphase and remainders were tested by FISH technique on the slide of metaphase cell. Results: Results of analyzing chromosome of 10 patients showed that 8 patients had Ph1 chromosome. 2 patients without Ph1 chromosome were patients who had not high of leukocyte count: 28x109leukocyte/l and 36x109leukocyte/l, respectively. In the FISH on the slide of interphase, all 5 patients had Ph1 chromosome and abl/bcr fusion gene. In the FISH on the slide of metaphase cell, 3 patients had Ph1 chromosome and abl/bcr fusion gene. Conclusion: FISH technique has been applied successfully to detect ABL/BCR gene in patients with chronic myelogenous leukemia.\r\n', u'\r\n', u'
Leukemia
;
Myelogenous
;
Chronic
;
BCR-ABL Positive/ pathology
4.Research progresses on the pathogenesis of bacterial biofilm in chronic rhinosinusitis.
Jing DU ; Chunyuan ZHAO ; Xin WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(8):446-448
The role of bacterial biofilms in the chronic diseases has been recognized more and more. The experts in the centers for disease control and prevention of the United States estimate that 65% of human bacterial infection is involved with the biofilms. In the recent study. it has been proved that there is a high correlation between the bacterial biofilm and the pathogenesis and prognosis of chronic rhinosinusitis(CRS). In order to elucidate the role of bacteria films in the pathogenesis of CRS, we reviewed various method of testing the bacterial biofilms in CRS, and summarized the related researches. Based on the detection researches and summaries, we conclude that bacterial biofilm can contribute to the continuance and development (diffusion and repeated) of CRS. It can lead to the continuous inflammation by influencing the immune system of the mucous membrane. While there is little research on the bacterial biofilm. Further researches will be needed for the exact mechanism of the bacterial biofilm in CRS. in order to find more effective therapeutic method and targets.
Biofilms
;
Chronic Disease
;
Humans
;
Sinusitis
;
microbiology
;
pathology
5.Ultrastructure of chronic liver diseases: From light to electron microscopy.
The Korean Journal of Hepatology 2002;8(1):112-123
No abstract available.
Chronic Disease
;
Human
;
Liver/pathology/*ultrasonography
;
Liver Diseases/*pathology
6.Renal Involvement of Chronic Myelogenous Leukemia Presenting as a Kidney Tumor.
Yonsei Medical Journal 2004;45(5):944-946
Renal involvement by leukemic cells is rare in chronic myelogenous leukemia (CML). Herein, this study reports a case of CML associated with renal involvement of leukemic cells, which occurred 1 and 1/2 years after the initial diagnosis. Abdomino-pelvic computed tomography revealed a 4.4 x4.2 cm-sized, low-density solid mass having a thick wall from the mid to lower pole of the left kidney. A peripheral blood analysis revealed blastic transformation of CML. The biopsied renal parenchyme was diffusely infiltrated by sheets of immature myeloid cells, polymorphonuclear leukocytes, and occasional eosinophils. Most of the infiltrating cells were positive for anti-neutrophil elastase, but negative for lymphoid markers. Therefore, differential diagnosis of a kidney tumor during the course of CML, especially in the time of blastic transformation, should be performed.
Aged
;
Female
;
Humans
;
Kidney Neoplasms/*pathology
;
Leukemia, Myeloid, Chronic/*pathology
7.Points in pathological diagnosis of chronic hepatitis.
Chinese Journal of Hepatology 2007;15(5):383-384
Biopsy
;
Hepatitis, Chronic
;
diagnosis
;
pathology
;
Humans
;
Liver Cirrhosis
;
diagnosis
;
pathology
10.Research Progress in Exosomes in the Pathogenesis of Bronchial Asthma.
Acta Academiae Medicinae Sinicae 2023;45(5):827-832
Bronchial asthma is a heterogeneous chronic inflammatory disease involving multiple immune cells and structural cells.It is characterized by airflow limitation,airway hyperresponsiveness,and airway remodeling,with complex pathogenesis.In recent years,the research on exosomes has developed rapidly.Exosomes are small vesicles secreted by a variety of cells and are naturally found in various biological fluids,with stability and biocompatibility.Exosomes from different cells are involved in pathophysiological processes such as airway inflammation,remodeling,and hyperresponsiveness through specific mechanisms and play a regulatory role in multiple links in bronchial asthma.This review focuses on the role of exosomes from different cells in the pathogenesis of bronchial asthma.
Humans
;
Exosomes/pathology*
;
Asthma
;
Lung/pathology*
;
Inflammation
;
Chronic Disease