To observe the regulative effect of applying garlic cream on acupoint Shenque (CV8) on circadian rhythm disorder induced by sleep deprivation.Methods:Twenty healthy adult men were randomly divided into normal group(group A),sleep deprivation group (group B) and treatment group (group C).Subjects in group B and C received 48-hour sleep deprivation,and in the meantime subjects in group C were treated by applying garlic cream on acupoint Shenque(CV8),while subjects in group A received no any treatment,then contents of serum noradrenaline (NA) and 5-hydroxytryptamine (5-HT) were detected.Results:The contents of NA in three groups all appeared typical circadian rhythm(P＜0.01 when group A is compared with group C,and P＜0.05 when group A is compared with group B).The peak value in group A was 158.377 and appeared at 10:56,peak value in group B was 291.529 and appeared at 19:44,peak value in group C was 255.964 and appeared at 17:06.The peak phase in group B shifted more obviously when compared with group A,and the peak phase in group C recovered slightly when compared with group B.The contents of 5-HT in group A showed typical circadian rhythm (P＜0.01) and the circadian rhythms in group B and C disappeared (P＞0.05).the peak value in group A was 196.563 and appeared at about13:10.Conclusion:The application of garlic cream on acupoint Shenque (CV8) Can adjust the disturbed circadian rhythm and accelerate the recovery of circadian rhythm.It is a simple and effective therapeutic method for adjusting circadian rhythm disorder.

Objective To explore the cerebral cortex activation in different swallowing periods using functional near-infrared spec-troscopy(fNIRS). Methods From October to December 2023,a total of 18 healthy adults were recruited to perform four tasks of visual stimulation,chewing,tongue tip sliding and repeated swallowing during fNIRS acquisition,to calculate the corti-cal activation β values covering a total of 41 channels in frontal,parietal and occipital lobes. Results During the preoral period,the bilateral pre-motor and supplementary motor cortex(PSMC),bilateral inferior pre-frontal gyrus,right visual association cortex(AVC),and left primary motor cortex(PMC)were significantly acti-vated(P<0.05).During oral preparation,the right pars triangularis(PTG),right frontal polar area(FPA),right dorsolateral prefrontal cortex(DPC),left primary somatosensory cortex(PSC),left PSMC and left PMC were sig-nificantly activated(P<0.05).During the transition between oral and pharyngeal phases,bilateral PSMC and bi-lateral PMC were significantly activated(P<0.05).Bilateral PSC,bilateral PTG,bilateral FPA,bilateral orbito-frontal area,bilateral PSMC,bilateral DPC and bilateral PMC were significantly activated during two consecu-tive periods of oral and pharyngeal phases(P<0.05). Conclusion The swallowing movement requires the coordination of the frontal,parietal and occipital cortex.The main activated brain areas are different in different swallowing stages,and the PSMC and PMC are involved in most swallowing stages.